@Clodida

Assistant Professor at #BNI Phoenix. Multiple Sclerosis and myeloid cells maniac.

 St. Louis
Joined July 2009
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We identify FKBP5 as a key regulator of myeloid-driven neuroinflammation in #MS 🔬 Elevated in CSF monocytes & microglia from MS 🧬 Inhibition boosts myelin clearance & reduces IFNγ signaling 🐭 SAFit2 improves EAE outcomes #JournalofNeuroinflammation rdcu.be/e3zGN
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中枢神経系でサイトカインネットワークが神経・免疫・グリア細胞間の情報伝達を担い、恒常性を維持する一方、その破綻が疾患を促し、さらに組織修復にも働く仕組みを整理した総説がNat Immunol誌に発表されました。 nature.com/articles/s41590-0…

Cytokine circuits in CNS homeostasis and disease

Nature Immunology - In their Review, Becher et al. discuss how selected cytokine networks preserve, destabilize and restore central nervous system integrity.

nature.com
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成体骨髄にCD4系譜の赤血球・骨髄系前駆細胞（EMPROR）が存在し、循環単球を介さずにマクロファージを供給する別経路を形成することを示し、成体での組織常在マクロファージ補充機構を拡張した論文がNat Immunol誌に発表されました。 nature.com/articles/s41590-0…

A CD4-lineage erythro–myeloid progenitor within the adult bone marrow defines an alternative...

Nature Immunology - Tissue-resident macrophages originate from distinct developmental sources, but their adult replenishment is thought to depend exclusively on circulating monocytes. Here Tikoo...

nature.com
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Nature Metabolism
@NatMetabolismOct 26
#Throwback PERSPECTIVE | Mark Mattson The cyclic metabolic switching theory of intermittent fasting nature.com/articles/s42255-0…

The cyclic metabolic switching theory of intermittent fasting

Nature Metabolism - In this Perspective, Mattson discusses that the beneficial effects of intermittent fasting (IF) are mediated by cyclic metabolic switching between ketogenic (fasting) and...

nature.com
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Paul G Thomas@PGTimmuneOct 26
Does TCR sequence predict cross-reactive profiles? Similar TCR sequences often shared peptide recognition profiles, but even sequence-distinct TCRs could recognize similar variants, suggesting multiple TCR solutions result in cross-reactivity. (9/12)
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nature
@NatureOct 26
50 years after the publication of The Selfish Gene, it's time for books that capture the complexity of life to take centre stage go.nature.com/4dXkdlX

The Selfish Gene, 50 years on — it’s time for an update

Nature - A focus on the gene alone has become outdated. Books that capture the complexity of life deserve centre stage.

nature.com
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Nat Rev Neurology@NatRevNeurolOct 26
New online! Use of animal models to understand CNS neuroimmunology — guidance from the International Society for Neuroimmunology White Paper Task Force dlvr.​it/TW3nN5
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John Lukens@LukensJohnROct 26
Chronic progressive demyelination induces a microglial state with lysosomal dysfunction @NatureNeuro nature.com/articles/s41593-0…
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John Lukens@LukensJohnROct 20
Dysregulated cholesterol trafficking through ABCA1 drives neurodegeneration in Parkinson’s disease @NatureNeuro nature.com/articles/s41593-0…
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Lifespan
@JoinLifespanOct 19
A new study found that NAD+ levels in whole blood stay surprisingly stable throughout adulthood. So why are scientists still studying NAD+? Learn more from Lifespan Magazine 📚️ lifespan.com/blogs/magazine/…

Blood NAD+ Levels Tell Us Less Than Many People Think

One of the easiest mistakes in science is to confuse a single measurement with the whole reality. We do it all the time. An investor watches a stock price and forgets that the ticker is not the...

lifespan.com
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Lifespan
@JoinLifespanOct 18
Mice engineered to overexpress klotho lived 20–30% longer with no signs of illness doi.org/10.1126/science.1112…

Suppression of Aging in Mice by the Hormone Klotho

A defect in Klotho gene expression in mice accelerates the degeneration of multiple age-sensitive traits. Here, we show that overexpression of Klotho in mice extends life span. Klotho protein...

science.org
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IJMSC@IJMSCtweetsOct 19
"Prior mental illness...was associated with an increased risk of active mental illness during a second pregnancy. One in four mothers with MS required mental health care...during the second pregnancy." doi.org/10.1177/135245852614… #MentalHealth #pregnancy #MultipleSclerosis
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Joe Sabatino@jsabatino37Oct 18
Antiviral and inflammatory immune signatures in anti-CD20-treated multiple sclerosis: a cross-sectional study link.springer.com/article/10…

Antiviral and inflammatory immune signatures in anti-CD20-treated multiple sclerosis: a cross-sec...

Journal of Neurology - CD20-targeting monoclonal antibodies are highly effective therapies for relapsing multiple sclerosis (MS). We examined how anti-CD20 therapy reshapes antiviral T-cell...

link.springer.com
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IFNγ-induced memory in human #macrophages is sustained by the durability of #cytokine signaling itself. From Aleksandr Gorin, Alexander Hoffmann and colleagues hubs.la/Q04B0P3Z0 📘 From our #Cytokines collection: hubs.la/Q04B0P610 #Cytokines2026
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Inducible human yolk sac myeloid progenitors model myeloid ontogeny and enable tissue-resident macrophage replacement in vivo cell.com/developmental-cell/…

Inducible human yolk sac myeloid progenitors model myeloid ontogeny and enable tissue-resident...

Martinez-Muriana and Fattorelli et al. develop an in vitro platform to generate human inducible yolk sac myeloid progenitors (iYSMPs) from PSCs. iYSMPs recapitulate human embryonic yolk sac progeni...

cell.com
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John Lukens@LukensJohnROct 16
Embracing macrophage complexity for research and translation. cell.com/immunity/fulltext/S… @ImmunityCP

Embracing macrophage complexity for research and translation

Ginhoux, Mulder, Arcila-Barrera, and Amit argue that macrophage identity is best understood not as a set of discrete subsets or a binary M1/M2 axis but as combinations of modular gene programs. They...

cell.com
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Oded Rechavi
@OdedRechaviOct 14
I want to tell you about something new today: we’re launching the @qedScience Insight Feed!🥂 I’m excited about it and want to tell you what it does and why we built it. Part of it is that I miss Science Twitter 😌

Missing Sci-Twitter and introducing QED's new "Insight Feed"

Article · @OdedRechavi
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Unique transcriptional and epigenetic programs of IgM, IgG, and IgA antibody-secreting cells (ASC) suggest that each ASC is a distinct lineage that dictates specific functional characteristics important for humoral immunity. Learn more: ow.ly/msTU50ZUWK3.
IgG-specific genes are enriched for ETS:IRF motifs and are found at cell cycle genes.

ALT IgG-specific genes are enriched for ETS:IRF motifs and are found at cell cycle genes.

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John Lukens@LukensJohnROct 14
Elp1 is required for myeloid differentiation and brain repopulation @Nature nature.com/articles/s41586-0…
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Takei Lab@LabTakeiOct 12
"rebuttal letterは、学術誌への投稿原稿を修正する際に極めて重要な文書です。ここでは、原稿の修正内容について、可能な限り好印象を与える形で伝える方法について解説します。" nature.com/articles/s41592-0…

How to write a rebuttal letter

Nature Methods - The rebuttal letter is a vitally important document when revising a manuscript for a journal. Here we discuss how to communicate about your manuscript revisions in the best...

nature.com
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Andreu Vilaseca
@andreuvilaseca7Oct 9
NEDA-3 at year 1 doesn't always mean stable🧵 New from @cemcat_em in @GreenJournal: 329 RMS patients starting a DMT, with serum NfL z-scores measured at baseline and at 12 months. If the zNfL did NOT drop during year 1, the odds of disease activity in year 2 were:
🔹 3x higher overall, independent of Y1 relapses and MRI
🔹 4.5x higher in NEDA-3 patients
🔹 14x higher in treatment-naïve patients In practice:
1️⃣ Measure sNfL at DMT start and at 12 months
2️⃣ Use z-scores, not raw values
3️⃣ No drop despite NEDA-3? Follow that patient more closely! It's a complement to the exam and MRI, not a replacement! Proud to be part of this work 👏
🔗 doi.org/10.1212/WNL.00000000… 
#MSsky #NeuroTwitter
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