Amplitude‐integrated EEG vs conventional video‐EEG for detecting neonatal seizures. Evidence from 16 studies (562 infants) aEEG has only moderate sensitivity and specificity for detecting 'neonates with seizures'. cochranelibrary.com/cdsr/doi… #Neonatology #EEG #Neuro

🚨 New Cochrane Review update: sustained inflation at birth 👶 Now includes 14 RCTs, 1766 infants. 📉 Evidence still low certainty. 🫁 Little to no effect on mortality; possible ↓ in ventilation need. 🔗 cochranelibrary.com/cdsr/doi… #Neonatology #SLI #PPV #CochraneReview #NewbornCare

New Cochrane review update: Can midazolam safely sedate newborns in NICUs? This updated review (388 neonates, 6 RCTs) finds the evidence is very uncertain on benefits/harms vs placebo, opioids, or non-pharma alternatives. cochranelibrary.com/cdsr/doi… #Neonatology #NICU #Cochrane

Pharmacological pain relief during ETS in ventilated neonates 📊 7 RCTs | 1242 infants 💊 Morphine may have little to no effect on pain scores or ventilation duration 💉 Midazolam may reduce pain (PIPP), but data very limited cochranelibrary.com/cdsr/doi…

Early vs expectant treatment for hs-PDA in preterm infants 👶 19 RCTs | 2323 infants 💊 Early/very early treatment likely makes little to no difference in mortality, CLD, IVH, or NEC ⚠️ Very early ibuprofen may ↑ mortality in extremely preterm cochranelibrary.com/cdsr/doi…

Updated Review: Peritoneal drainage vs laparotomy for surgical NEC/SIP in preterm VLBW infants 👶 3 RCTs | 496 infants ⚖️ Little to no difference in mortality or neurodevelopment ⚠️ Drainage may ↑ risk of cerebral palsy & need for later laparotomy cochranelibrary.com/cdsr/doi…

Cochrane Network Meta-Analysis: What’s the best primary non-invasive respiratory support for preterm infants? 👶 61 RCTs | 7,554 neonates 📉 NIPPV & NIHFV may reduce risk of treatment failure & intubation vs CPAP/HFNC ⚠️ Certainty evidence: low to very low cochranelibrary.com/cdsr/doi…

🆕 Cochrane Network Meta-Analysis: Which non-invasive mode best prevents extubation failure in preterm infants? 👶 54 RCTs | 6,995 infants 📉 NIPPV & NIHFV reduce treatment failure & reintubation vs CPAP/HFNC ⚠️ Data limited for infants <28 wks GA 🔗 cochranelibrary.com/cdsr/doi…

🍼 Cochrane review on early discharge for stable preterm infants (gavage feeding): 🔎 No clear effect on mortality, readmissions, or serious adverse events 📉 Evidence from 1 small, old RCT → very low certainty Full review 👉 cochranelibrary.com/cdsr/doi…

We included 11 RCTs (852 infants): - 5 studies acupuncture vs no treatment or sham treatment; - 4 vs oral sweet solution; - 2 vs other types of Traditional Chinese Medicine treatments (e.g. foot massage or reflexology). We identified 4 ongoing studies. cochranelibrary.com/cdsr/doi…

We analyzed 79 studies (7197 infants, 326 nurses, 12 physicians) across 26 countries using 27 clinical rating scales. Neonatal pain scales showed very low-certainty evidence, raising serious concerns about their validity and reliability in neonatal care. cochranelibrary.com/cdsr/doi…

Although widely used, there are insufficient data regarding the benefits and harms of proton pump inhibitors (PPI) for the treatment of preterm infants with gastroesophageal reflux disease. cochranelibrary.com/cdsr/doi… Only 2 studies, enrolling a total of 62 infants, met our criteria.

New Cochrane review: Acupuncture for neonatal abstinence syndrome in newborns 🔎Limited evidence from 2 RCTs: no clear benefits or harms established ⚠️ Clinicians should proceed with caution cochranelibrary.com/cdsr/doi… This review is published in memory of Berndt #Acupuncture #NAS

No evidence from RCTs is currently available to evaluate the benefits and harms of fluid restriction for the treatment of symptomatic PDA in preterm infants. We identified no ongoing studies. cochranelibrary.com/cdsr/doi…

The 2024 update of this review included 4 studies (464 infants); all studies evaluated acupuncture versus no treatment. Limited evidence on acupuncture for HIE in neonates. Link: cochranelibrary.com/cdsr/doi… #NeonatalCare #HIEResearch

Surfactant therapy guided by tests for lung maturity in preterm infants. Listen to this new podcast by Mike Clarke, with two study authors (@GretaSibrecht @BorysFranciszek) and lead investigator for one of the ongoing studies (Anna Lavizzari). cochrane.org/podcasts/10.100…

Cochrane update NCPAP may be more effective than no CPAP in preventing extubation failure in preterm infants if applied immediately after extubation We consider there is no need for further research on this intervention, which has become standard practice cochranelibrary.com/cdsr/doi…