Fantastic Research Day on sleep. Special thanks to all speakers!! Couple interesting insights: - ARPAH is funding the collection of a gigantic dataset on 100M EHR records to disentangle sleep's pathology. This will be massively helpful for tx translation efforts - With tx routes we like targeting AD/PD via SWS + glymphatic clearance a core issue pharma wants to see for trials is subtyping/patient selection - Habituation/homeostatic adjustment would also be a concern for even the best tx ideas To stay informed about these research days we host (like Shelby's next week on data), sign up here: compound-newsletter.vercel.a…

New Post: Disentangling Depression All top drugs for MDD launched 25-65yrs ago Yet MDD is the 2nd largest contributor to years lived with disability And we still diagnose MDD based on subjective self-reported symptom checklists We break down the future for precision psychiatry

We're hosting a Research Day on Ozempic for Sleep! Last year we published in-depth research on sleep frontiers We're now bringing together the world's top researchers and entrepreneurs pushing the bounds of both basic science and translation RSVP here: luma.com/249fnmh6

New Post: What Comes After HBM? It might be crazy to start a new memory company at outrageous highs... but maybe it's just crazy enough We profile speculative technologies that could lead to: 1) Faster than HBM Access Speeds or 2) HBM-like Bandwidth with NAND-Like Density