We study vertebrate photoreceptors
St. Louis, MO
Joined August 2021
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Corbo Lab at Washington University in St. Louis retweeted
🚨 Our new paper is out in @iScience_CP! 🐟
3D morphometrics, CFD & Pareto optimality reveal high-performing designs that early vertebrates never evolved—challenging models of evolutionary constraint.
@Macro_Fun @BristolPalaeo @CellPressNews
🔗 sciencedirect.com/science/ar…
Corbo Lab at Washington University in St. Louis retweeted
Are deep-sea fishes truly circumglobal? This new study reports extensive cryptic (hidden) diversity in the Sternoptyx and Argyropelecus across the abyssal plains worldwide, with divergence time of tens of millions of years.
researchgate.net/publication…
Welcome back. Lots of science still here! Check this out: The role of abiotic and biotic factors in the unequal body shape diversification of a Gondwanan fish radiation.
researchgate.net/publication…
Corbo Lab at Washington University in St. Louis retweeted
Museum Resource 🐠 Fish Families of the World Gallery
📌 This gallery of museum vouchered specimens is designed to support instructors in need of teaching materials.
Browse: floridamuseum.ufl.edu/discov…
Searchable gallery includes photos, CT scans, 3D models, x-rays & more!
ALT a screenshot of a list of several kinds of fish with their scientific and common family name below each image of a preserved fish specimen including a jack, codlet, catfish and flounder
Corbo Lab at Washington University in St. Louis retweeted
A supergene and genomic mosaicism are associated with phenotypic evolution in Galápagos tree finches nature.com/articles/s41467-0… @NatureComms
Corbo Lab at Washington University in St. Louis retweeted
Our new paper @CellReports, led by @katsu_s_minami et al.! 🎉🧬🔬
cell.com/cell-reports/fullte…
Machine learning-assisted Repli-Histo labeling and single-nucleosome imaging reveal distinct transcription-dependent chromatin constraints across euchromatin and heterochromatin. Congrats!
Corbo Lab at Washington University in St. Louis retweeted
Amphibians were able to live in the sea 237 million years ago, according to new research
go.nature.com/4zkZcKz
Corbo Lab at Washington University in St. Louis retweeted
Biologists saying AI doesn't offer much to biomedicine might sound like hubris, but it's more of an embarrassing confession about how important we think our intelligence is to progress in biomedicine (as opposed to plain luck and elbow grease). 1/10
Corbo Lab at Washington University in St. Louis retweeted
真核生物に最も近縁なアスガルド古細菌から見つかった祖先系の微小管
ヘイミダル古細菌から見つかったAtubA/Bというタンパク質であり、GTP依存的にヘテロダイマーが重合し、シームを持ち動的不安定性を示す4本鎖の繊維を形成していた #BNTNJC
science.org/doi/10.1126/scia…
Corbo Lab at Washington University in St. Louis retweeted
"Climatic niche conservatism istherefore ancient in crocodile-line archosaurs, but not completely static."
I like this "evolution through temperature space" phylogram aesthetic.
CC: @svalver
Climatic niche conservatism shapes the macroevolution, extinction, and survivorship of crocodile-line archosaurs | Science Advances science.org/doi/10.1126/scia…
Corbo Lab at Washington University in St. Louis retweeted
What if you could see light in a whole new way?
Michael Shribak (@mshribak), a senior scientist at the MBL, developed and patented a polychromatic polarization microscope that allows him to visualize an "invisible" property of light.
🔗 Read more here: go.mbl.edu/light
Corbo Lab at Washington University in St. Louis retweeted
Regulatable in vivo gene expression via adaptamers sciencedirect.com/science/ar…
Corbo Lab at Washington University in St. Louis retweeted
Just out: some fish 🐟 lost their green opsins but evolved a functional alternative from duplicated red (LWS) opsins — much like the evolution of red-green vision in primates! 🔴🟢 Different lineages, similar evolutionary solutions! Go red opsins! Go gobies! Thks co-authors🤗
Corbo Lab at Washington University in St. Louis retweeted
🧬🌊 New preprint from our lab: DO1 Cas9, the first Cas9 nuclease characterised from the deep ocean — recovered from a metagenome at 1,500 m in the Atlantic.
❄️Cold-adapted: it cuts DNA efficiently at low temperature, where mesophilic SpCas9 retains only residual activity. 🧵1/4
Corbo Lab at Washington University in St. Louis retweeted
It seems to me that this paper fundamentally rewrites the standard "textbook" story of human evolution in three major ways:
(1) The idea of a "pure" modern human origin in Africa is destroyed because every human alive today would be the result of a massive genetic "remixing" of ancient lineages occurring mostly outside Africa — lineages that had previously been separated for over a million years.
(2) Neandertals are not a separate parallel branch of humanity, but rather essentially a hybrid population of early humans expanding into Europe 300,000 years ago and mixing heavily with them.
(3) The previous timeline of the Out of Africa theory is significantly pushed back by a "bicontinental range expansion" that occurred 300,000 years ago.
New David Reich preprint proposes the expansion of early modern humans into Europe 300,000 years ago, likely originating from the Near East and/or Northeast Africa — long before the migrations about 50,000 years ago posited by the Out of Africa theory.
biorxiv.org/content/10.64898…
Corbo Lab at Washington University in St. Louis retweeted
Check out our new preprint led by @mileshuseyin unexpectedly discovering Polycomb 3D interactions independent of cPRC1.
Miles led this ambitious study. He's also on the faculty job market, and I can't recommend him highly enough for important and comprehensive science!
1/9) Excited to share my preprint on Polycomb 3D chromatin interactions from my postdoc with @Anders_S_Hansen!
We were surprised to find that canonical PRC1 doesn't seem to be the only contributor to these interactions:
biorxiv.org/content/10.64898…
Corbo Lab at Washington University in St. Louis retweeted
Long time since their preprint..
Huge amount of work.
Mechanisms of transcription control by distal enhancers from single-gene nanoscopy: Cell cell.com/cell/fulltext/S0092…
Corbo Lab at Washington University in St. Louis retweeted
Borrowing an idea from one research discipline to solve a thorny problem in another is an age-old scientific trick. Charles Darwin’s theory of natural selection, for example, famously inspired algorithms in computer science that “evolve” solutions to complex problems.
But such clever leaps are fleetingly rare. For #AI, however, hopping between fields can be a breeze.
Researchers highlighted that ability with the release of 36 preprints produced with a single suite of AI tools called BootLoops. The so-called harness can be used with any large language model, such as Anthropic’s Claude or OpenAI’s ChatGPT.
And in just 3 months, researchers used Claude outfitted with BootLoops to cross-pollinate at a massive scale, spotting—and precisely solving—problems in seemingly unrelated fields that share the same mathematical structures.
The resulting papers range widely, from figuring out the age of sunspots, to analyzing government health policies, to attempting to decipher a mysterious medieval manuscript.
Learn more: scim.ag/4ybX3zw
ALT Problems in 22 scientific fields had solutions hiding in plain sight. An AI has found them Teams led by physicist used “BootLoops” software to produce 36 papers in weeks on everything from linguistics to health policy
Corbo Lab at Washington University in St. Louis retweeted
【ほぼ同じDNAなのに姿が一変？鳥が持つ「超遺伝子」】ガラパゴス諸島のフィンチの全ゲノムを調べると、全体はほぼ同じなのに、くちばしや体格を劇的に変える単一の「超遺伝子」が多様化を促していたことがわかった。Nat Commun誌 doi.org/10.1038/s41467-026-7…
Corbo Lab at Washington University in St. Louis retweeted
When genome editing got going, the ability to trace a mammalian embryo's development to organ generation in exquisite detail was not envisioned. Now it's been accomplished by 2 independent groups. A big week in developmental biology
science.org/doi/10.1126/scie… @JShendure @ScienceMagazine
cell.com/cell/fulltext/S0092… @jonathanweisman @CellCellPress
nature.com/articles/d41586-0… @nature @ewencallaway
Corbo Lab at Washington University in St. Louis retweeted
Recently, I've been getting deep into [auto-optimization], which is basically a bubble-wrapped auto-research loop. Almost everything I point it at has led to massive speed/memory improvements. There is so much to improve about the genomics ecosystem.