Physician-scientist @UWMedicine @DermatologyUW focused on advanced microscopy, keratinocyte biology, teledermatology, and genetic/autoimmune blistering disease.
Seattle, WA
Joined January 2019
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New paper from @SimpsonLabUW @DermatologyUW is online @JCI_insight🍾We found ERK hyperactivation disrupts cell-cell adhesion in epidermis, linked this pathway to both drug-induced & spontaneous Grover disease & identified MEK inhibition as a novel therapy: insight.jci.org/articles/vie…
Excited to be representing @SimpsonLabUW in sunny 😎 San Diego 🌴 for #ASCB2024 #CellBio2024 @ASCBiology
Starting the migration to the other place, using handle @SimpsonLabUW …hoping to find the old #sciencetwitter and #dermtwitter crowds.
Proud of med student Rafael Homer whose summer research project @SimpsonLabUW @DermatologyUW won 2nd place in the @uwsomwwami Wyoming site poster competition! Rafael also won a travel award to attend the Western Medical Research Conference & was chosen for an oral presentation🤩
Exciting week @SimpsonLabUW @DermatologyUW celebrating🍾our newest paper @JCI_insight (see separate🧵). which uncovered a mechanism that drives the pathology #Grover disease and was reversed using MEK inhibitors. Special thanks to Arti for making an amazing Indian lunch buffet!
New paper from @SimpsonLabUW @DermatologyUW is online @JCI_insight🍾We found ERK hyperactivation disrupts cell-cell adhesion in epidermis, linked this pathway to both drug-induced & spontaneous Grover disease & identified MEK inhibition as a novel therapy: insight.jci.org/articles/vie…
Hope this will finally move the needle for severe drug reactions like SJS & TEN, nightmare consults in #dermatology. No Rx has great evidence to halt skin/mucosal sloughing that can be fatal. JAKi remains to be rigorously tested in patients/RCT but could change standard of care.
Spatial proteomics identifies JAKi as treatment for a lethal skin disease | Nature nature.com/articles/s41586-0…
Cory Simpson, MD, PhD, FAAD (he/him) retweeted
Nature research paper: Spatial proteomics identifies JAKi as treatment for a lethal skin disease go.nature.com/3A1ld7K
This program has been an outstanding opportunity for networking with peers, receiving grant feedback, learning how to navigate the new PI path, and getting sage career advice from leading physician-scientists. 10/10 highly recommend @the_asci. Consider applying
Early-Faculty Physician-Scientists!
Nominations are open for the ASCI Young Physician-Scientist Awards.
Award Benefits include access to @JointMeeting, networking and career development opportunities.
Deadline: Oct. 23
More info: buff.ly/3XUL9ex
Finally, we reasoned the same mechanism could drive spontaneous Grover disease (ie, not drug-induced). Accordingly, we found ERK hyper-activation in Grover disease lesions and propose MEK inhibitors may be therapeutic for this idiopathic disorder lacking any FDA-approved therapy.
Proud of all co-authors & grateful to our collaborators @umichmedicine & @PennSbdrc including @drdremchu. Thanks to @NIH_NIAMS & @FIRST_Skin for lab support and @LEOFondet for funding my effort to find shared mechanisms & treatment strategies for rare skin #blistering diseases.
Cory Simpson, MD, PhD, FAAD (he/him) retweeted
Early-Faculty Physician-Scientists!
Nominations are open for the ASCI Young Physician-Scientist Awards.
Award Benefits include access to @JointMeeting, networking and career development opportunities.
Deadline: Oct. 23
More info: buff.ly/3XUL9ex
Great lunch @SimpsonLabUW @DermatologyUW for lots of celebrating including Arti’s birthday 🥳 More good news to share soon now that I’m out from under the cloud of this R01 submission 😮💨📝 ✅🤞
Cory Simpson, MD, PhD, FAAD (he/him) retweeted
I'm excited to announce that I am on the job market for tenure-track Assistant Professor positions in cell biology, with a focus on the integrated roles of keratin filaments and organelle biology!
Please feel free to reach out, share/RT🔁!
Very proud of Akshata for representing @SimpsonLabUW @DermatologyUW at the @UWISCRM Fall Symposium. She did a great job at her 1st poster session explaining her work developing quantitative methods to assess our model of #HaileyHailey disease, a rare #skin #blistering disorder.
