@CosrLab

Center for Omics Sciences @SanRaffaeleMI. Promoting multi-omics research to understand diseases development, diagnosis and cure. Tweets are our own view

 Milano, Lombardia
research.hsr.it/en/centers/omics-sciences.html
Joined February 2019
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🧬 "SurfR: Riding the wave of RNA-Seq data with a comprehensive Bioconductor package to identify Surface Protein Coding Genes" introduces SurfR, an R package enabling streamlined analysis of surface protein genes from #RNASeq data. Read more: doi.org/10.1093/bioadv/vbae2… #DataAnalysis @aurora_maurizio @ASTascini
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💻 SurfR, a comprehensive R/Bioconductor package for surface protein gene analysis from RNA-Seq data, is available with source code, tutorials, and use cases on GitHub: github.com/auroramaurizio/Su… #OpenSource #ComputationalBiology #GeneAnalysis

GitHub - auroramaurizio/SurfR_UseCases: R code for SurfR Bioconductor package use cases

R code for SurfR Bioconductor package use cases. Contribute to auroramaurizio/SurfR_UseCases development by creating an account on GitHub.

github.com
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Happy to present our #spatialomics 🔍🗺️work on #esophageal cancer @EACRnews Genomics multiOmics and computational biology meeting! Great program, inspiring talks and good friends! GiuliaLopatrielllo GiuseppinaArbore @OSanraffaele @COSRLab #cosmx
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Kudos to @ValentinaGiansa for this and thanks to all people involved! 👇👇👇 Scalable Integration of Multiomic Single Cell Data Using Generative Adversarial Networks academic.oup.com/bioinformat…

Scalable integration of multiomic single-cell data using generative adversarial networks

AbstractMotivation. Single-cell profiling has become a common practice to investigate the complexity of tissues, organs, and organisms. Recent technologica

academic.oup.com
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New lab pic? @ValentinaGiansa @LilloCarlin0 #retreatosr2024
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Happy our SurfR package has been accepted in bioconductor! A a bioinformatics R package to surf the cells’ surfaceome starting from NGS data #bioinformatics #surfaceome #Rpackage @CosrLab @ASTascini @marcojmorelli github.com/auroramaurizio/Su…
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Please help me #RT this 2-years postdoc position #Bioinformatics / #DataScience at the crossing of single-cell #Genomics and #longreads sequencing. With @UniTrieste and @AreaSciencePark in Trieste! Fun work, people and science: more on #LinkedIn linkedin.com/jobs/view/37928…

Offerte di lavoro per Ricercatore qui: Italia ( (Posizioni aperte (57))) | LinkedIn

Today’s top 57 Ricercatore jobs in Italia. Leverage your professional network, and get hired. New Ricercatore jobs added daily.

it.linkedin.com
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Attention please! 📣Registration to the yearly event of our association @ERCinItaly are now OPEN! Register here: ercinitaly.eu/evento-ercinit… Be part of the Italian frontier research community!
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Merry Christmas and happy new year from @CosrLab 🎅🎄⭐️🥂❄️ #Christmas2023
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"This is an excellent study!" The rev said. Check out our peripheral #nerve #regeneration paper at authors.elsevier.com/c/1i5ab… Congrats to the brilliant distinguished gentlemen Dario Bonanomi and Ganesh Bhat, dear @COSRLab colleagues @ilDepoMI and Santo Diprima, and all authors!
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💥BIG PAPER ALERT💥 So excited to share our latest, out now @Nature! Here, we uncover a spatially confined interplay between subsets of IL-1b+ macrophages and tumor cells that fuels pathogenic inflammation in pancreatic cancer (1/n) nature.com/articles/s41586-0…

IL-1β+ macrophages fuel pathogenic inflammation in pancreatic cancer

Nature - Single-cell and spatial gene expression analyses of pancreatic ductal adenocarcinoma uncover a population of interleukin-1β-expressing macrophages that drive inflammatory...

nature.com
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Join us at SR-TIGET in Milan! We are recruiting a PhD student to study how #telomeric damage contributes to defective #immunity as part of a fantastic international consortium @IMMERGE_MSCA_DN, a #MSCAction #DoctoralNetwork. @MyUniSR @Telethonitalia @SanRaffaeleMI. Apply below👇
IMMERGE@IMMERGE_MSCA_DN4 Oct 2023
📢@IMMERGE_MSCA_DN is a #MSCActions #DoctoralNetwork (DN) aiming to train a New Generation of Scientists in Europe in #immunology, #multiomics & #GeneEditing to fight against #PrimaryImmunodeficiencies We just opened the call! 📯 📯 📯 Find out more 🔎 👉immergeproject.eu
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36 datasets, 26 protocols, 1.7 million harmonized cells! First edition Human Neural Organoid Cell Atlas. Important work from @zhisong_he @josch_f Leander Dony @TreutleinLab @fabian_theis. Strong community effort @Sergiu_P_Pasca @GiorgiaQuadrato. #organoids @ETH_BSSE @IHB_Research
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Un nostro nuovo studio apre nuove strade per lo sviluppo di immunoterapie innovative per curare il tumore del colon-retto. hsr.it/news/2023/ottobre/svi…

Tumore colon-retto e nuove prospettive di cura: lo studio del San Raffaele

Un nuovo studio del San Raffaele apre nuove strade per lo sviluppo di immunoterapie innovative per curare il tumore del colon-retto: approfondisci.

hsr.it
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Check out the paper featured on the cover of this month’s Cancer Research: Preexisting Immunity Drives the Response to Neoadjuvant #Chemotherapy in Esophageal #Adenocarcinoma, by Arbore et al. bit.ly/45U1GjX
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Two papers characterizing the critical role of CD8+ T cell subsets in COVID vaccination and infection - now in @NatImmunol! * @EJohnWherry lab (@markmpainter): nature.com/articles/s41590-0… * Our collab. w/Dan Littman's lab (@Bingjie_Zhang_+Rabi Upadhyay): nature.com/articles/s41590-0…

Prior vaccination promotes early activation of memory T cells and enhances immune responses during...

Nature Immunology - Wherry and colleagues define the kinetics of vaccine-primed recall immune responses during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) breakthrough infection,...

nature.com
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Excited that veloVI is out @naturemethods! Led by @adamgayoso & @PhilippWeiler7 w awesome @YosefLab, we combine deep generative modeling with a mechanistic single-cell transcriptional model for better RNA velocity analysis with uncertainty quantification. nature.com/articles/s41592-0…
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Don’t miss this publication by @DCampolungo and Gabellini lab. Happy I had the chance to contribute to this incredible work unraveling DUX4-r role in acute lymphoblastic leukemia | @ScienceAdvances science.org/doi/10.1126/scia…

DUX4-r exerts a neomorphic activity that depends on GTF2I in acute lymphoblastic leukemia

DUX4-r oncogenic activity requires GTF2I, whose targeting abrogates DUX4-r chromatin binding and target activation in leukemia.

science.org
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As schist is now listed in the @scverse_team ecosystem, we’ve updated the documentation, including some advanced use scenarios schist.readthedocs.io/en/lat…
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Take home message: non-commercial methods need (a lot) of improvement as they aren’t optimized. Can’t agree more, as we are still working on optimization of our protocols, so is there a future without (or with less) 10x? nature.com/articles/s41587-0…
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