@CuylenLab
 Heidelberg, Germany
embl.org/groups/cuylen/
Joined January 2022
  • Tweets38
  • Following97
  • Followers294
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Cuylen Lab retweeted
Yuki Hayashi@YH_YukiBioMar 26
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 I’m excited to share that our work is now published in The EMBO Journal! Ki-67 shapes the nucleolus by anchoring chromatin via its amphiphilic properties A short summary is in the thread below, or you can jump straight to the paper here. link.springer.com/article/10…

Ki-67 shapes the nucleolus by anchoring chromatin via its amphiphilic properties

The EMBO Journal - The nucleolus, a membrane-less organelle essential for ribosome biogenesis, adopts variable shapes across cell types and in response to environmental conditions, yet the...

link.springer.com
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How can you tackle emerging questions in cellular organisation, adaptation, and robustness? Let's find out together! This is your reminder to register for the EMBO | EMBL Symposium 'Cellular mechanisms driven by phase separation'! 🧬🦠 The meeting will bring together scientists from cell biology, biophysics, biochemistry, molecular biology, structural biology, developmental biology, polymer physics, and soft matter physics to study condensates in biology and disease. #EESPhaseSeparation Whether you are returning or new to the community, we hope you can join us next year! 📅 19 – 22 May 2026 📍 Heidelberg and Virtual 👉 Submit your abstract by 10 Feb 2026: s.embl.org/ees26-08-x
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How to tackle emerging questions in cellular organisation, adaptation, and robustness? To find out, join the EMBO | EMBL Symposium 'Cellular mechanisms driven by phase separation'! 🧬🦠 The meeting will bring together scientists from cell biology, biophysics, biochemistry, molecular biology, structural biology, developmental biology, polymer physics, and soft matter physics to study condensates in biology and disease. #EESPhaseSeparation Whether you are returning, or new to the community, we hope you can join us next year! 📅 19 – 22 May 2026 📍 Heidelberg and Virtual 👉 Submit your abstract by 10 Feb 2026: s.embl.org/ees26-08-x
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🎉 Big congrats to @v_sorichetti and @SaricLab! Their simulations reveal how Ki-67’s charge distribution drives chromosomes to cluster together. Grateful to have contributed from @EMBL, with a special shout-out to our alumni PhD student @AHA_Alberto. 📖 journals.aps.org/prxlife/abs…

Charge distribution of the coating brush drives interchromosome attraction

RNA bridges between charged regions on chromosome surfaces drive long-range attraction and clustering, revealing a condensate-like mechanism tunable by charge patterns.

journals.aps.org
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Ki-67 shapes the nucleolus by anchoring chromatin via its amphiphilic properties biorxiv.org/content/10.1101/… #biorxiv_cellbio

Ki-67 shapes the nucleolus by anchoring chromatin via its amphiphilic properties

The nucleolus, a membrane-less organelle essential for ribosome biogenesis, adopts variable shapes across cell types and in response to environmental conditions, yet the mechanisms regulating its...

biorxiv.org
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For more detail, check out this great thread from one of the first authors @YH_YukiBio explaining the findings:
Yuki Hayashi@YH_YukiBio25 Jul 2025
Excited to share our new preprint on @biorxivpreprint from our great team @EMBL! biorxiv.org/content/10.1101/… If the nucleolus is liquid-like, why does it often appear irregularly shaped in proliferating mammalian cells? What controls the nucleolar shape? #PhaseSeparation #Nucleolus
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Ever wondered why nucleoli often have such complex shapes—despite behaving like liquids? If liquids tend to form spheres, why don’t nucleoli? What shapes them? We explore this in our latest preprint @embl. Great work led by Daja Schichler & @YH_YukiBio! biorxiv.org/content/10.1101/…
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Interested in rapid imaging-based screening or sorting of rare cell populations? A new era of cell sorting has begun! Check out our latest review in @TrendCellBio on novel flow cytometers with imaging capabilities. Congrats, @terrabyte21! cell.com/trends/cell-biology…
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Cuylen Lab retweeted
EMBL@embl21 Aug 2024
EMBL Heidelberg researchers found how chromosomes switch from repelling each other to becoming sticky during cell division. They saw that protein Ki-67 turn chromosomes’ surface into a liquid-like glue that helps in the formation of daughter nuclei. 🔛 embl.org/news/science-techno…
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Extremely happy to see our story out in @MolecularCell! doi.org/10.1016/j.molcel.202… We show how Ki-67 & pre-rRNA phase separate, gluing mitotic #chromosomes together! 🧼🧬🧲 @EMBL @EMBLHeidelberg @UniHeidelberg @ISTAustria @CuylenLab @SaricLab @EllenbergLab
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Our latest paper is out today @MolecularCell! Led by a @AHA_Alberto and with important contributions from @SaricLab & @EllenbergLab! We show how chromosomes shift from being repulsive to becoming attractive during mitosis. Read all about it here: cell.com/molecular-cell/full…
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I am extremely happy to share my @biorxivpreprint of my PhD work @EMBL! 🔬👨🏽‍🎓 A liquid-like coat mediates chromosome clustering during mitotic exit biorxiv.org/content/10.1101/…
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Our new preprint describing how Ki-67 switches from a chromosome surfactant to a chromosome glue is online! Fantastic work lead by @AHA_Alberto @embl. Many thanks to our great collaborators from @SaricLab and @EllenbergLab. biorxiv.org/content/10.1101/…
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Cuylen Lab retweeted
EMBL@embl20 Nov 2023
The EIPOD-LinC postdoctoral programme is open for applications! Are you interested in self-designed interdisciplinary research on projects exploring life in context? Then take a look at our fellowship programme: embl.org/about/info/postdoct…
A text box saying: "Join us to work on exciting interdisciplinary research projects in an international setting!". Below is the EMBL EIPOD logo. In the background, there is the planet Earth with several lines collecting different points on it.

ALT A text box saying: "Join us to work on exciting interdisciplinary research projects in an international setting!". Below is the EMBL EIPOD logo. In the background, there is the planet Earth with several lines collecting different points on it.

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Excited to share our collaborative work with the Mahamid, Müller and @EllenbergLab! This has been a fantastic team effort @embl led by Herman Fung, @yukicosmos239 and @VeijoS.
Nature Methods@naturemethods6 Nov 2023
Exciting new work on genetically encoded multimeric tags for subcellular protein localization in cryo-EM from the Cuylen-Haering & Mahamid labs. nature.com/articles/s41592-0…
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Cuylen Lab retweeted
EMBL@embl14 Jul 2023
Image-enabled cell sorting (ICS) – a next-generation cell sorting method – is helping EMBL researchers gain new insights into cellular function in health and disease, as well as to explore other innovative applications. embl.org/news/science/the-po…
A close-up of the flow chamber of an ICS machine, with a scientist’s hand in the foreground.

ALT A close-up of the flow chamber of an ICS machine, with a scientist’s hand in the foreground.

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Out today and freely available, a tool many in the image analysis community have been waiting for! PyImageJ: A library for integrating ImageJ and Python @EliceiriK @UWMadisonLOCI @ctrueden @CiminiLab @DrAnneCarpenter nature.com/articles/s41592-0…
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Registration now open for the 2023 Physical Biology Circle Meeting (30/01-01/02) at #mpipks Dresden. All talk slots for #PhD students / #postdocs! Register at pks.mpg.de/cmbp23 before 15/11. (Only members of participating nodes can apply.) #biophysics #mechanics #softmatter
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Job Opening!! 🔔⏰🔔 ... In a joint position with the Korbel lab @EMBL we are looking for a skilled computer scientist! Details see add below! Please spread the word and fwd to whoever might be interested! embl.org/jobs/position/HD022…
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