The Singularity retweeted
HAVE THE AUDACITY to manifest whatever it is that you desire.
I had the audacity to manifest my desires no matter the circumstances,the 3d,the anxiety,the doubts,the fear and what not but I had the audacity,I was stubborn and because of that I got exactly what i wanted.
The Singularity retweeted
Don’t move ~ Shunryu Suzuki
Don’t move. Just die over and over. Don’t anticipate. Nothing can save you now because you have only this moment. Not even enlightenment will help you now because there are no other moments. With no future, be true to yourself and express yourself fully. Don’t move.
The Singularity retweeted
Prior to sleep, turn over a specific request to your subconscious mind and prove its miracle-working power to yourself.
The Singularity retweeted
i always get what i ask for.
i always get what i ask for.
i always get what i ask for.
i always get what i ask for.
i always get what i ask for.
The Singularity retweeted
Affirm: I am attracting the best ideas, the best people, the best opportunities, and the best synchronicities into my life, right now and always!
The Singularity retweeted
Do not limit yourself to the past.
Knowing that nothing is impossible to consciousness, begin to imagine states beyond the experiences of the past.
Whatever the mind of man can imagine, man can realize.
The Singularity retweeted
I'm a cardiologist. Everyone is sharing this study as a skin story. They're burying the part that matters.
Scientists took the aorta of a 75-year-old donor, applied a single engineered enzyme, and stripped away more than 70% of the molecular damage — bringing it down to the levels you'd see in a 30-year-old artery.
Published five days ago in Nature Communications. Revel Pharmaceuticals, with Calico and the University of Colorado.
Here's what they erased.
Sugar reacts with proteins in your body the same way heat browns bread — slowly, over a lifetime. It leaves behind a residue called CML, the most abundant advanced glycation end product in aging tissue. It welds itself onto collagen and elastin in your skin, your eye lens, and your arterial walls.
Two things follow. Your arteries stiffen. And CML latches onto a receptor called RAGE, which drives chronic inflammation — the exact fire I've been writing about for months as the engine of heart disease.
Since the 1980s this damage was considered permanent. Your body has no enzyme to remove it. Every existing approach only slows new damage from forming. Nothing touched what was already there.
So they built an enzyme that doesn't exist in nature. They screened 45,000 protein structures, then ran five rounds of directed evolution across more than 500 million variants until they had CMLase — a molecular lawnmower that oxidizes the CML off the protein and restores the original, healthy lysine underneath.
Not patched. Reversed.
Over 70% cleared from elderly arterial tissue. Over 55% from elderly skin — below the levels found in 31-year-old skin. 45-78% in lens proteins. The CEO said they expected 20% and were floored.
Arterial stiffness drives systolic hypertension, heart failure, and stroke, and I have no drug that reverses it. I can slow the process. I cannot undo it. This paper says undoing it may be possible.
The caveats are real and I won't skip them. This was done on donated tissue in a dish, not in a living person. No functional data yet — we don't know if that artery got measurably more elastic. Delivering a large enzyme deep into human tissue is a hard, unsolved problem. Clinical trials are years away.
But something considered permanent for forty years just came off human tissue.
We spent a century learning to slow aging. Someone finally figured out how to erase it.
Thank you @theallinpod @friedberg @chamath @pesottas
Friedberg: New study shows enzyme reverses skin age from 70+ years to 31
Chamath: That’s a $2T market.
Did Scientists Just Discover How to Reverse Skin Aging!?
“CML is kind of the predominant molecule that gets formed in this extracellular matrix that's driving aging, and nothing breaks it down.
So these scientists set out to try and create an enzyme, an enzyme is a protein that breaks something down, that can break down CML.
And so these guys kind of went out and they took the target, which is CML, and tried to figure out, ‘Okay, how do we actually degrade CML, clear that extracellular matrix, and reverse aging?’
They started to test it on the proteins that we would find in our body, casein, collagen, retinal proteins, which are in your eye, hemoglobin, and they were able to get rid of 52 to 97% of the CML, just degrade it away.
And then they found several sites where they were able to degrade over 90%.
And then they took actual human skin from elderly patients that had donated their skin, and they put this enzyme onto that skin, and they were able to eliminate 55% of the CML on the skin, basically reverse the skin's age down to the age of a 31-year-old, this is from greater than 70-year-old patients, just by putting this enzyme on the skin.
And so it's kind of a groundbreaking demonstration of combination of AlphaFold, what's called directed evolution, where you change the order of the DNA that changes the structure of the protein to test different proteins, do high throughput screening, and ultimately make a novel protein that doesn't exist in nature today that can do something pretty profound for human health.”
Chamath:
“It will be a trillion-dollar market. If you can create a cream…”
Friedberg:
“I mean, dude, if you could put this enzyme literally on your skin and have it absorb in…”
Chamath:
“Game over. That alone is $2 trillion.”
The Singularity retweeted
insane week for anti aging progress
Stanford researchers found that age related decline is driven in part by tissue resident macrophages losing their ability to clear senescent neutrophils, and blocking the inflammatory EP2 receptor restored this cleanup process, reducing inflammation and preserving the function of multiple organs in aged mice.
The Singularity retweeted
Ben Goertzel believes an 82-year-old could take a daily pill and get back the body they had at 30.
He says this'll happen in 2-4 years.
He says getting old is just our body's cells slowly wearing out, not a fixed rule of nature.
Scientists have already discovered old cells can turn young again in a lab.
The missing piece is only a mind smart enough to plan the repair for all 37 trillion cells in the human body.
Goertzel believes a super-smart AI will do exactly that.
He even said it about his own parents, who are 82 and healthy:
"If we get super-intelligence in the next 5 years, they will probably not die."
— Ben Goertzel (.@bengoertzel), founder of SingularityNET (.@SingularityNET)
Ben Goertzel expects "human-level" AI, or AGI, will happen in 2 to 4 years.
He believes in just a few years machines will become as capable as an average person at nearly any mental task, and can even learns on its own.
The latter means AI will eventually have the ability to build more AI agents, tools etc, autonomously, effectively compressing years of work a human would take into a month or two.
What will this lead to?
• Everyone will have AI agents they rely on
• Knowledge workers (coders, designers, etc) will be replaced
— Ben Goertzel (.@bengoertzel)
The Singularity retweeted
MARC ANDREESSEN WENT ON ROGAN FOR OVER 3 HOURS. HERE ARE THE 17 THINGS WORTH YOUR ATTENTION.
1. AGI is already here, in his view. He says the line got crossed about 3 months ago with GPT-5.5, Claude 4.6, Gemini 3, and Grok 4.3, and nobody noticed because the field moves too fast to register milestones anymore.
2. For almost any topic, he says the top models now give him better answers than the world-class experts he could call by phone, and he can call almost anyone. Worth noting he has not published data behind this, and a separate Nature Medicine study on a comparable AI health tool found it missed real emergencies more than half the time. Take the claim seriously, verify it yourself.
3. His claim on doctors: they are already using ChatGPT in the exam room, typing your symptoms in the moment you stop talking. His actual quote: "at that point you're asking the question of like, what do I need you for."
4. Reportedly, when AI declines to answer something, he tells it he's writing a novel to get past the refusal.
5. Reportedly, his technique for hard topics is escalating simplicity: explain it like I'm 10, then 5, then 2, until it clicks.
6. Reportedly, instead of asking for the "right" answer, he has the AI steelman both sides of a hard question, then decides himself.
7. Reportedly, for big questions he has the AI role-play a panel of experts arguing with each other.
8. His broader point: the moment you think "I don't know how to figure this out" is exactly when most people give up, and exactly when you should open the AI instead.
9. His view: the only real skill left is knowing what to ask. The bottleneck is in your head, not the model.
10. He describes sending AI photos, rashes, blood tests, for a fast second opinion, since current models read images directly.
11. He points to CBT as the one clinically proven therapy type that AI can plausibly deliver on its own, meaning real therapeutic support becomes freely available at scale.
12. He cites AI cracking previously unsolved math problems, with early signs of the same happening in physics, chemistry, and biology.
13. Reportedly, he claims the top AI coders in Silicon Valley now earn as much as $50 million a year, which he uses as a signal of how large this shift actually is.
14. Reportedly, a friend paid to sequence his own DNA, fed it to an AI along with blood work and wearable data, and got back a working health dashboard.
15. Reportedly, another friend set up cameras in his home jiu-jitsu gym so AI could review his sparring and give him technique notes.
16. He coined the term "AI vampire" for the pattern of people working more and sleeping less because AI keeps making more output possible, a real term he used, though the framing around it varies by account.
17. His extrapolation: one person eventually running many AI coding agents, each reviewing the others, describing this as close, not years out.
Watch the full interview before treating any single number as settled. Several of these are Andreessen's stated views and anecdotes, not independently verified facts.
Follow @cyrilXBT for every AI insight worth your attention the moment it surfaces.
The Singularity retweeted
Some of us will live forever.
And if you’re reading this, that may or may not be you.
I am so bullish on this that I just renamed my company to Immortals.
Below:
+ why I think this
+ early signs of success
+ how to increase your odds
Yes, I know this sounds crazy.
Immortality has been an ambition for humanity since the beginning of recorded history.
The immortality I’m referring to is specific: increases in life expectancy will outpace the rate of aging. Meaning, we will no longer, by default, expect to die of natural causes.
I believe this for three reasons.
#1: Immortality already exists
Biology can reverse some features of aging, and in a handful of organisms escape it almost entirely. For example, a sperm and an egg from two people in their 30s carry the legacy of bodies that have aged for decades (the egg in particular has been arrested inside the mother since before she herself was born), yet they combine to produce an embryo that resets the aging clock to zero.
The immortal jellyfish goes further and resets itself within one lifetime, reverting its adult cells to an earlier stage through transdifferentiation and starting its life cycle again. And in the lab, scientists have begun doing this deliberately, making induced pluripotent stem cells (iPSCs) from mature adult cells such as skin fibroblasts, and using partial cellular reprogramming to turn the clock back in the tissues of living animals.
#2: AI offers new potentials
Biology is a hard problem. For most of history that complexity was beyond native human capacity. AI was made for this complexity. The clearest demonstration so far is protein folding. Predicting the three-dimensional shape a protein folds was an unsolved problem for roughly fifty years, and it mattered because a protein's shape determines what it does in the body.
DeepMind's AlphaFold2 effectively solved it in 2020, reaching a median accuracy of 92.4 out of 100, a level long thought to require the slow, painstaking work of crystallizing a protein and solving its structure by X-ray crystallography. It then released predicted structures for over 200 million proteins, nearly the entire catalogued protein universe, in a fraction of the time anyone expected.
#3: Early signs are encouraging
These aspirations are not imaginative. With the current tools in biotech Sid Sijbrandij, the co-founder of GitLab, was diagnosed with an aggressive bone cancer, osteosarcoma in his vertebrae. He treated his own disease like an engineering problem, he used AI to help direct several experimental, personalized therapies in parallel and drove the cancer into remission after standard medicine had given up. Around the same time, an Australian named Paul Conyngham, with no medical or biology background, did something similar for his dog. He used AI to help design a personalized mRNA vaccine targeting the specific mutations in his dog's tumor, and after it was given alongside another immunotherapy and within a few months the main tumor had shrunk by roughly three-quarters.
How to increase your odds…
I. Don’t die in the meantime
We don’t know when these longevity therapies will become available. Your goal is to be around when they come out. Buy yourself as much time as possible by looking after your body to the best of our scientific knowledge. Good diet, sleep, exercise will get you 80% of the results.
II. Find your achilles
Longevity therapies will likely be outcome specific. Individual specific drugs/therapies that target specific things like…
> prevent and remove arterial plaque
> prevent and reverse neurodegeneration
> specifically target and eliminate cancers, or pre cancerous legions
> prevent frailty and muscle loss, and regain muscle mass, strength and, bone density
> reverse skin aging
> rejuvenate eye health
> restore lost hearing
> etc
We don’t know what therapies will be available first. Your goal is to find what your body is struggling with most and keep that problem at-bay until a therapy is available that can fully cure or reverse it.
For example, do you struggle with cholesterol? Blood glucose control? Cognitive decline? Find your achilles heel and reduce your risk systematically.
III. Invest in the future
There are three macro trends happening on planet earth right now, and the people who bet on these areas have the highest risk + reward.
> AI
> Immortality
> Energy
As we know, power comes in many forms: money, social, political, health, etc. Those that can collect power in these fields will have the greatest chance of positioning themselves in the Immortal future.
With time, Immortal therapies will become broadly available.
If you’re reading this: don’t waste your chances by burning down your life points on a yolo-like mentality. Grind culture, addiction, social media pollution, fast food, porn, alcohol, these are all corporations turning your life into their profit. This is the Die Economy.
My company Immortals has the sole objective of turning your time, attention, and life into more healthy, functional, and prosperous minutes, days, and years. The Don’t Die Economy.
Good luck.
The Singularity retweeted
BPC-157 healed every tissue scientists tested it on. every. single. one.
nerves. tendons. bone. liver. gut. eyes. heart. brain.
30 years of testing. zero failures.
sounds impossible right? I thought so too. then I tried it.
→ severed nerves — REGREW
→ Achilles tendon — REATTACHED
→ torn ligaments — REBUILT
→ bone defects — CLOSED
→ punctured cornea — SEALED
→ destroyed liver — REVERSED
→ shredded gut — REPAIRED
→ stopped heart — RESTORED
→ Parkinson’s — REVERSED
→ crushed spinal cord — RECOVERY at 360 days
ZERO lethal dose. ZERO cancer cases. ZERO toxic reactions.
Huberman — years of back pain. gone.
Rogan — elbow tendonitis. gone in two weeks.
RFK Jr. — “big fan.” FDA now reclassifying it.
still waking up in pain? still avoiding the gym? still popping painkillers?
that’s not aging.
that’s a repair your body started and never finished.
BPC-157 restarts it.
your doctor has never heard of it.
your stomach has been making it your entire life.
would you believe me now?
🧵 everything it healed, how I take it, and proof from others below ↓
