We study the role and regulation of NADPH oxidases in immunity - https://xitter.cf/t.co/NGi4HtxMNN
United Kingdom
Joined February 2021
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Our latest paper on EROS has now been published in @eLife! A great collaborative effort @fra_magnani and many more! doi.org/10.7554/eLife.76387
Delighted to be co-leading this collaboration with Nic Wisniacki at GSK
A £50million plus investment in towards a better understanding of renal and respiratory disease. More here:
cam.ac.uk/news/cambridge-and…
Very exciting paper from @ALNeehus and @casanova_lab
1/ Exactly one year after my PhD defense, I am very excited to share with you the last chapter of my thesis published today in @Nature about humans with inherited TNF deficiency: nature.com/articles/s41586-0….
this is an excellent opportunity!
Interested in #genomics? Fulled funded UKRI PhD studentship available in @lab_peters at @imperialcollege London. UK Home students eligible for this scheme.
UK transplant will miss the wonderful @frank_dor - good luck in your new post and come back often !
Dear @RotterdamTrans, thank you for loaning @frank_dor to London for the last few years.
Frank, thank you for everything. We will miss you. Don’t be a stranger! 😘
@Bynvant @KessarisN @KikiSran @CityUrology @Mr_G_Papadakis @CJCallaghanTx @LoukopoulosI @rhz59 @PGogalniceanu
delighted to have worked with @lab_peters @teichlab @Muzz_Haniffa @ClatworthyLab on this study. great work by first authors Emily Stephenson, Lisa Dratva and Erin Macdonald-Dunlop. Thanks to all our patients most of all
Our study on severe #COVID19 in end stage kidney disease patients with matched pre-pandemic samples from a broad cohort of 61 individuals is on medRxiv! medrxiv.org/content/10.1101/…
Evaluation of clonal T cell dynamics showed that the fastest expanding clones were significantly enriched in known SARS-CoV-2 specific sequences and shared across multiple patients. Our analyses also revealed novel TCR clones that are likely reactive to SARS-CoV-2.
We identified gene expression signatures of severity, with the majority of pathways differentiating mild from severe disease in B cells and monocytes.
We used single-cell RNA-seq, CITE-seq and immunoreceptor sequencing, derived from 187 longitudinal samples from 61 patients.
We collected samples before and during COVID-19 infection from the same individuals. We performed dense longitudinal sampling during infection, allowing us to study intra-individual changes over time among patients with a wide spectrum of COVID-19 severity.
We studied two cohorts of end-stage kidney disease patients prior to the introduction of vaccination. This is one of the patient groups most at risk from severe COVID-19.
Thomas Lab retweeted
I've put together a set of links for the various career development advice articles I've been writing for the past ~20 years, here arranged by career stage:
listonlab.uk/careers/
Hope it is helpful to some people!
Great opportunity !
I'm recruiting a Postdoc for a comparative innate immunity project to define cross-species mechanisms of pathogen sensing, in collaboration with @ClareBryant13 and Sandhya Ganesan. Can involve travel to partners in India. Please RT. Full advert here: jobs.cam.ac.uk/job/47019/
Thomas Lab retweeted
A privilege and honour to receive the Raine award and I hugely enjoyed sharing our science at #UKKW2024
Dame June Raine DBE, CEO of @MHRAgovuk presents @drbstewart with this years Raine Award (in memory of Tony Raine & awarded for significant contributions to renal research) at #UKKW2024 science session after the talk "Mapping immunity in the human kidney with single cell genomics"
So great to see this work published and delighted to have collaborated with the Lee lab. Fantastic work from Christina Stankey, Christophe Bourges, Lea Maxie Haag and colleagues, led @Dr_James_Lee
nature.com/articles/s41586-0…
Thomas Lab retweeted
In this study, interferon-γ was found to play a large role in the pathogenesis of APS-1. Results were confirmed in studies in animals and led to a trial of ruxolitinib in five patients, who had dramatic responses. Read the full study results: nej.md/4bXoKkG
ALT Original Article The Role of Interferon-γ in Autoimmune Polyendocrine Syndrome Type 1 Panel A shows photographs of hair on the scalp of Patient 1 before and after ruxolitinib treatment. The graph shows serum levels of interferon-γ before and after treatment. Panel B shows the macroscopic appearance of gastric mucosa during endoscopy in Patient 2. The graph shows serum levels of interferon-γ before and after treatment.
2/2 -sciencedirect.com/science/ar…
it's on the role of EROS in endothelial cells - our favourite protein takes on some different roles outside the immune system!
Delighted to share our new paper - a fantastic collaboration with Markus Waldeck Weiermair, Thomas Michel and the brilliant Michel lab at Harvard
sciencedirect.com/science/ar…