@DalkaraLab

We investigate various approaches of gene delivery for effective gene-based therapies and create animal models that mimic the molecular mechanisms of disease

 Paris, France
institut-vision.org/fr/therapies-geniques-et-modeles-animaux-pour-les-maladies-neurodegen
Joined January 2018
  • Tweets56
  • Following160
  • Followers227
7Media
We are online 🥳 @CellRepMethods! Great collaboration here @InstVisionParis brings #alloptical holographic approaches to the retina! #optogenetics #retina #neuroimaging cell.com/cell-reports-method…

All-optical inter-layers functional connectivity investigation in the mouse retina

Spampinato et al. demonstrate an optical system for two-photon functional imaging and holographic optogenetic photostimulation at axially distinct planes. The system is used to map the functional...

cell.com
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Her experience suggests that such personalized devices could help those who’ve exhausted all other treatment options. trib.al/zEsELl9
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José-Alain Sahel explains in few minutes that which is the fruit of a life devoted to research to overcome blindness and to give hope ! Congrats ! 👏👏👏 @Falling_Walls @InstVisionParis @PittTweet @Sorbonne_Univ_ @Inserm @CNRS @Reseau_Carnot @MedecineSU falling-walls.com/discover/v…
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A blind man can perceive objects after a gene from algae was added to his eye. bit.ly/3pmxDgF

A blind man can perceive objects after a gene from algae was added to his eye

Researchers are trying to genetically reengineer people’s retinas to restore vision.

technologyreview.com
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World first. #retinitispigmentosa patient partially recovers vision after optogenetic treatment. Published in @NatureMedicine Great work from @IOB_Roska @GenSightBio @PittTweet @IOB_ch @Quinze_Vingts @InstVisionParis @StreetlabVision nature.com/articles/s41591-0…

Partial recovery of visual function in a blind patient after optogenetic therapy

Nature Medicine - Combined intraocular injection of an adeno-associated viral vector, encoding an optogenetic sensor, with light stimulation via engineered goggles enables partial recovery of...

nature.com
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DalkaraLab retweeted
Wei Li@Wei_Li_Vision1 Jun 2020
Mice can see color, but only for the upper visual field (behavior by @denmanlab, @rclayreid, retinal physiology by @kfrankelab, @teulerlab, @mameister4). WHY? Our new paper @eLife may provide a possible answer. doi.org/10.7554/eLife.56840

True S-cones are concentrated in the ventral mouse retina and wired for color detection in the...

Unique 'true' S-cone and S-cone bipolar cell distribution patterns in the mouse retina are previously unappreciated anatomical features that support enhanced short-wavelength signaling for color...

elifesciences.org
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Anyone interested in retinal regeneration who got excited by the recently published paper in @nature should read this thread. Important word of caution on the interpretation of data.
This Post is from an account that no longer exists. Learn more
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DalkaraLab retweeted
H1 Connect@H1Connect17 Mar 2020
In these unusual times, make sure to avoid the panic and keep yourself informed about the facts. Check out our Faculty's top recommendations on the #coronavirus family and #COVID19 👉 f1000.com/prime/covid19 #COVID #CoronavirusOutbreak
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Coverage by @nature on gene editing CRISPR/Cas9 approach to CEP290 related blindness in a patient via #retina #surgery. Congrats Mark Pennesi @CaseyEye ! Best wishes that you patient does well. Historic! nature.com/articles/d41586-0…
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After Valentina Emiliani yesterday, the @InstVisionParis still in the spotlight at #Sfn2019 with José Sahel discussing optogenetic strategies for vision restoration
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Well that prime editor work by @davidrliu 's lab is just fantastic. Putting the reverse transcriptase on the Cas9-RNA complex is such an elegant idea.
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Today we describe prime editing, a very versatile new approach to genome editing in human cells without cutting the DNA double helix. We integrated a reverse transcriptase with a disabled CRISPR enzyme to copy virtually any edit from an engineered guide RNA into a target site...
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Interested in an #interdisciplinary PhD using computational modelling, calcium imaging and #optogenetics to study locomotor behaviour in #zebrafish. Apply to our #international training program across Europe! Visit zenith-etn.com #neuroscience #ITN #zenith @MSCActions
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.@DalkaraLab, @MarusaLampic, @mgaritah at @InstVisionParis use optogenetically engineered photoreceptors to restore visual function in mice. go.nature.com/35p7inT Out now @NatureComms

Restoration of visual function by transplantation of optogenetically engineered photoreceptors

Nature Communications - A challenge in cell therapy for photoreceptor degeneration is inducing the grafted cells to grow and maintain light sensitive outer segments. Here, the authors use...

nature.com
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DalkaraLab retweeted
zenith-etn@zenith_etn4 Oct 2019
Applications for the ZENITH PhD program will close on January 5th, 2020. Students will begin their projects by September 2020.
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Transplantation of optogenetically engineered photoreceptors restores visual function! Work by the @DalkaraLab and Duebel Labs. nature.com/articles/s41467-0…
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Our new paper showing that concomitant loss of both CRB1 and CRB2 in mouse Müller glial cells mimics an LCA-like phenotype is now online. Thanks to our collaborators @DalkaraLab, @KosterLab and @NIN_knaw #Retina #Blindness #CRB1 academic.oup.com/hmg/advance…
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