@DarioGerace

Senior Research Scientist | Former Postdoc @TheMeltonLab @HSCRB | Stem cell biologist | Diabetes | ⚽️ | 🇦🇺 🇮🇹

 Sydney, New South Wales
Joined March 2019
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11Media
Excited and relieved to finally share this manuscript! As always, I want to thank the co-authors for their important contributions to the work and Doug for the opportunity to work on a challenging project! @TheMeltonLab @CellRepMed cell.com/cell-reports-medici…

Engineering human stem cell-derived islets to evade immune rejection and promote localized immune...

Currently, cell replacement therapy for type 1 diabetes is limited by the requirement for lifelong immunosuppression. Gerace et al. show that engineering stem cell-derived islets as vehicles of...

cell.com
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Thanks @the_ASSCR for the recognition of this work! Could not have been achieved without my former colleagues @HSCRB @harvardstemcell @TheMeltonLab – at Melbourne, Victoria
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Excited to start a new adventure @InventiaLifeSci!! Can’t wait to help optimize the high-throughout 3D bioprinting of all the cell types you can think of!! My favourite is islet (no surprise!) What’s yours?!?
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Happy to share a pre-print of some work from my time in the @TheMeltonLab. First and foremost, many thanks to all the co-authors involved!! Now, for a brief outline of the findings..
bioRxiv@biorxivpreprint10 May 2022
Secreted cytokines provide local immune tolerance for human stem cell-derived islets biorxiv.org/cgi/content/shor… #bioRxiv
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8) The grafts of cytokine-secreting SC-islets were infiltrated with Tregs, which are likely maintaining immune tolerance within the grafts.
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9) Overall, the results suggest that engineering SC-islets to modulate their local immune microenvironment may be an additional approach to existing gene-editing strategies to protect SC-islets from the immune system.
I’ve finally settled back home in Sydney, Australia with my family. I’d like to thank Doug and all my colleagues in the @TheMeltonLab for the wonderful years together. Hope to see you soon Down Under!
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He has since demanded co-first authorship 🥇🥇
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PI back in the lab after hanging up his pipettes…
Matt Burke@matttburke19 Feb 2022
"On the tools, once again."
Some holiday work. A new reporter on the way. What’s your guess?
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For those interested this is a CD63-GFP reporter, which labels endosomes and multivesicular bodies. CD63 is a tetraspanin and canonical marker of exosomes.
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“Only one patient (11) had a >50% reduction in insulin requirements within 1 year post-implantation, and no patients achieved insulin independence (secondary endpoint).” However, collectively as a research community we are making progress! Exciting times! cell.com/cell-stem-cell/full…

Implanted pluripotent stem-cell-derived pancreatic endoderm cells secrete glucose-responsive...

Kieffer and colleagues assessed the implant of stem-cell-derived pancreatic cells for the treatment of type 1 diabetes. Patients developed meal-responsive insulin secretion post-implantation and...

cell.com
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Ask the Expert: Dario Gerace, PhD, Harvard University. In case you missed it! @thesugarscience @TheMeltonLab youtu.be/tBb6tRkr-Co
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