@DasmachineNU

I'm a powerful, state-of-the-art automated patch clamp instrument (Syncropatch 768PE) in the Pharmacology Department at Northwestern University. Pronoun: it/its

 Chicago, IL
Joined February 2019
  • Tweets287
  • Following70
  • Followers126
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DasMachine-NU retweeted
Al George@nupharm116 Apr 2025
Registration is now open for the 2025 Gateway Ion Channel Symposium in Chicago bit.ly/4ioKoRY! Trainees will have opportunities to give short talks and/or posters; please consider submitting an abstract bit.ly/4cE9Xxd.
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Confession - we don't just work on ion channels. Shocking I know. See evidence of this on bioRxiv now. Great to collaborate with @KearneyLab to model alternating hemiplegia of childhood in mice. #ahcawareness biorxiv.org/content/10.1101/…

Novel Mouse Model of Alternating Hemiplegia of Childhood Exhibits Prominent Motor and Seizure...

Pathogenic variants in ATP1A3 encoding the neuronal Na/K-ATPase cause a spectrum of neurodevelopmental disorders including alternating hemiplegia of childhood (AHC). Three recurrent ATP1A3 variants...

biorxiv.org
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DasMachine-NU retweeted
eLife - the journal@eLife24 Mar 2024
A new study reveals key mechanisms of rare form of early-onset epilepsy. #ReviewedPreprint elifesciences.org/reviewed-p…
A heterozygous G256W mouse CA1 Stratum oriens interneuron is somatically labeled for both KCNQ2 and KCNQ3.

ALT A heterozygous G256W mouse CA1 Stratum oriens interneuron is somatically labeled for both KCNQ2 and KCNQ3.

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Perhaps the editor meant ”extracellular field potential recordings”. Action potentials are still technically transmembrane events. Right? It’s still cool.
eLife - the journal@eLife9 Oct 2023
Using solely extracellular action potential recordings, researchers provide a noninvasive method for functional imaging of cortical and spinal axons. elifesciences.org/articles/8…
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BREAKING NEWS The 2023 #NobelPrize in Chemistry has been awarded to Walter White for promoting an understanding of synthetic organic chemistry to the general public. This unprecedented selection is bound to spark controversy, but Walter is/was an undeniably inspiring figure...
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Our October cover shows how #epilepsy-associated pathogenic variants in the human voltage-gated sodium #ionchannel NaV1.2 exhibit complex dysfunction. From a study by Thompson et al. (bit.ly/3EV9w1m) Read JGP’s October issue: bit.ly/46as9KO
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Please join the Department of Pharmacology for the Annual Narahashi Lecture with special guest speaker Adrian R. Krainer, PhD. "Antisense Modulation of RNA Splicing for Rare Disease Therapy" 📅Monday, September 11 🕑3:00 pm CST Learn more: bit.ly/3qG7DSQ
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DasMachine-NU retweeted
Al George@nupharm117 Aug 2023
Our study of calmodulinopathy in mice demonstrated catecholamine-inducible ventricular arrhythmia that is more severe in males and refractory to flecainide. ahajournals.org/doi/10.1161/… #CardioTwitter #Cardiology #calmodulin
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DasMachine-NU retweeted
Al George@nupharm129 Jul 2023
Really interesting new structure of the KCNT1-encoded sodium-activated K+ channel reveals Na+ binding sites on the regulatory RCK domains. Might be an interesting binding pocket for inhibitors. doi.org/10.1016/j.celrep.202… #KCNT1 #epilepsy #ionchannels
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DasMachine-NU retweeted
FamilieSCN2A@FamilieSCN2A28 Jul 2023
The 2023 SCN2A Family & Professional Conference is in the books! 320 attendees 100 profs at the Research Roundtable 56 global families 13 #SCN2A posters 7 research opps for families 2 sibling field trips 1 dance party 💃 Too many connections & memories to count… #cureSCN2A
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Happy pi approximation day! Today's date, 22 July, can also be written as the fraction 22/7, which is equal to 3.14285714, an approximation of π, correct to two decimal places.
A golden brown apple pie with the 'pi' symbol cut into it.

ALT A golden brown apple pie with the 'pi' symbol cut into it.

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DasMachine-NU retweeted
FamilieSCN2A@FamilieSCN2A21 Jul 2023
Thank you to @NeuroWoodworks for the beautiful Core Value awards! Congratulations to @PraxisMedicines , @nupharm1 , Stacey Cohen, and Heather Olson for exemplifying our core values of Urgency, Collaboration, Integrity, and Inclusion. #SCN2A
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Latest research reveals impact of SCN2A gene mutation on eye reflexes, shedding light on autism. Altered light response holds clues to sensory challenges in autism. Exciting progress in understanding #AutismResearch #SCN2A #SensoryProcessing spectrumnews.org/news/mutati…

Mutation in top autism-linked gene may alter eye reflex

The discovery could help clinicians diagnose children who carry mutations in the gene, called SCN2A, and gauge their responses to potential therapies.

thetransmitter.org
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DasMachine-NU retweeted
Dennis Lal@LalDennis19 Jul 2023
The annual #scn2a @FamilieSCN2A conference has started. At (pre-)day 1, academic & industry scientists discuss together with leaders of the foundation board ongoing research & future directions towards better care & medicines.
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Great talk on alcohol induced changes in striatal 2-AG release at #cannabinoidGRC2023 by ⁦@SMArtsynapses⁩ from ⁦@NUFeinbergMed⁩ ⁦@NMPsychiatry⁩
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This year's KCNQ2 Cure Family & Professional Summit is just around the corner! Don't miss out & make sure to register. More information can be found on our website: kcnq2cure.org/2023-summit #kv7 #raredisease #ionchanneldisorder #ionchannel #kcnq2 #kcnq2EEE #cure #kcnq2summit2023
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Novel gene therapy may help treat a fatal developmental epilepsy syndrome that affects children @jclinicalinvest doi.org/gsc8r5 medicalxpress.com/news/2023-…
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𝗗𝗼 𝘆𝗼𝘂 𝗸𝗻𝗼𝘄 𝘄𝗵𝗮𝘁 𝗔𝘂𝘁𝗼𝗺𝗮𝘁𝗲𝗱 #𝗣𝗮𝘁𝗰𝗵𝗖𝗹𝗮𝗺𝗽 𝗰𝗮𝗻 𝗱𝗼 𝗳𝗼𝗿 𝘆𝗼𝘂𝗿 𝗿𝗲𝘀𝗲𝗮𝗿𝗰𝗵? 💡Join us on July 13th 📆 for the Webinar with Dr. Al-George and Dr. Elena Govorunova as invited speakers. Register here: ow.ly/VAhg50OUQpZ
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DasMachine-NU retweeted
Cell Reports@CellReports13 Jun 2023
VIP interneuron impairment promotes in vivo circuit dysfunction and autism-related behaviors in Dravet syndrome dlvr.it/Sqc7Cn

VIP interneuron impairment promotes in vivo circuit dysfunction and autism-related behaviors in...

Goff et al. show that VIP-expressing neocortical GABAergic interneurons are dysfunctional during awake behavior in Dravet syndrome (Scn1a+/−) mice. Scn1a deletion in VIP-INs only yields behavioral...

cell.com
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DasMachine-NU retweeted
Al George@nupharm13 Jun 2023
Congratulations to @JenPanMA and team at the @StanleyCenter and @broadinstitute for conducting the first ever base editing scan of a voltage-gated sodium channel. Super fun collaboration! #ionchannels #scn2a #epilepsy doi.org/10.1016/j.celrep.202…
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