@DavidJMarcus2

Postdoctoral Scholar in the @mbruchas lab, alumnus of the @SachinPatelLab .

 Seattle, WA
Joined July 2019
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I’m excited to share the most recent study from the @mbruchas lab, which represents the culmination of my postdoctoral work, and serves as the platform for my future research programs investigating the in vivo role of the endocannabinoid signaling system! biorxiv.org/content/10.1101/…

Endocannabinoids facilitate transitory reward engagement through retrograde gain-control

Neuromodulatory signaling is poised to serve as a neural mechanism for gain control, acting as a crucial tuning factor to influence neuronal activity by dynamically shaping excitatory and inhibitory...

biorxiv.org
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Really excited to have been invited to give this seminar! Please come check it out!
Friedman Brain Institute@SinaiBrain16 May 2025
NOT TO MISS! On Friday, May 23rd, 3 PM, JOIN #MSNseminars when hosts Drs. @Mr_Beto_Corona & @veronikakondev welcome @UWMedicine's Dr. @DavidJMarcus2 who will present “Endocannabinoids facilitate transitory reward engagement via retrograde gain control". Location: Hess 5-101
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A real tour de force from many many @mbruchas lab members and across the UW community! Shines the light on an understudied and underappreciated brain region.
Andrew Luskin@aluskin7 May 2025
New paper on arousal in the brain! What controls the controller?
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A little late to the party, but this is a really exciting new technology for simultaneous in vivo pharmacology and photometry, developed through a collaboration of the @mbruchas and @ProfJohnARogers labs!
Sean Piantadosi@PiantadosiSean14 Apr 2025
Excited to share work from @mbruchas & @ProfJohnARogers labs led by myself, @MinKyuLeePhD and @MingzhengWu with critical help from @NeuroLuxInc, @AvilaROAD, @NUro_science, and Dr. Yonggang Huang. Work proudly supported by @NIDAnews, @NIMHgov, and the @NIH BRAIN Initiative.
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The first @pact_lab paper of 2025 is out now in @npp_journal 🤩 "Endocannabinoid contributions to the perception of socially relevant, affective touch in humans" led by @M_R_Jones & @ConnorHaggarty, ft. @abby_lunge @canna_brain @Heilig_Lab & others nature.com/articles/s41386-0…

Endocannabinoid contributions to the perception of socially relevant, affective touch in humans

Neuropsychopharmacology - Endocannabinoid contributions to the perception of socially relevant, affective touch in humans

nature.com
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If you’re interested in understanding how cannabis can increase anxiety and cause panic reactions in some people, this paper might help👇🏾👇🏾👇🏾👇🏾 Cannabinoid Modulation of Central Amygdala Population Dynamics During Threat Investigation biorxiv.org/content/10.1101/…

Cannabinoid Modulation of Central Amygdala Population Dynamics During Threat Investigation

Cannabinoids modulate innate avoidance, threat-reactivity, and stress adaptations via modulation amygdala-associated circuits; however, the mechanisms by which cannabinoids modulate amygdala repres...

biorxiv.org
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Huge congrats to all the PECASE winners: whitehouse.gov/ostp/news-upd… @TheErinCalipari @xiaosigu @NeuroTejeda @lukejchang @DWWilliamsLab @lindsayschwarz @KanakaRajanPhD @kpleil1 @IjeomaOparaPHD @DrAyanaJordan and others not here! So well deserved!
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Thank you to @StellaLab11, @cloverpharm, and @cloverpharm for the continued discussion and helping to refine my story, and especially for the creation and validation of the Linear Track pipeline for supervised behavioral classification.
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Thank you to the @yulonglilab for the generation and characterization of the GRABeCB sensor, which made this study possible.
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biorxiv.org/content/10.1101/… Congrats to @DavidJMarcus2 @cloverpharm @StellaLab11 @Graphtablet @mbruchas & many other colleagues.

Endocannabinoids facilitate transitory reward engagement through retrograde gain-control

Neuromodulatory signaling is poised to serve as a neural mechanism for gain control, acting as a crucial tuning factor to influence neuronal activity by dynamically shaping excitatory and inhibitory...

biorxiv.org
Lab of Dr. Nephi Stella, University of Washington@StellaLab1111 Jan 2025
New study from the UW CB-network! Find out about the role of eCBs in transitory reward engagement in mice using multiple cell specific genetic approaches, in vivo eCB sensor monitoring, and the linear track pose estimation unbiased technology that we developed.
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Pleased to share a new preprint of our collaborative effort with Sean Hill’s lab and @BlueBrainPjt led by Dr. Polina Litvak. biorxiv.org/content/10.1101/…

Biophysical modeling of thalamic reticular nucleus subpopulations and their differential contribu...

The burst firing mode of thalamic reticular neurons plays a pivotal role in the generation and maintenance of sleep rhythms and is implicated in sleep-related deficits characteristic of neurodevelo...

biorxiv.org
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Hello ACNP! I'm David and I am a postdoc in the @mbruchas lab at the University of Washington studying how endogenous cannabinoid signaling facilitates motivated behavior. Please swing by poster T61 on Tuesday from 5-7 to hear more about my work over the last four years!
Neuropsychopharmacology@npp_journal6 Dec 2024
We are officially on the ground in Phoenix so it's time for the #ACNP2024 role call 📣 Introduce yourself, your science, tell us if you're a veteran or first-timer, promote your poster/talk/favorite social - whatever you want, this is your space to say it ⬇️
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David Marcus retweeted
Max Joffe@mejoffe24 Oct 2024
Our lab is hiring at all levels. Currently have postings up for entry level, more senior, and postdoc positions. Please reach out if interested! careers.upmc.com/job/2106897… careers.upmc.com/job/2106904… cfopitt.taleo.net/careersect…
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Excited to share a new preprint about my postdoc work in the von Zastrow lab! Using conformational biosensors, we investigated the mechanism by which the mu-opioid receptor increases G protein activity on endosomes. biorxiv.org/content/10.1101/…

Opioid receptors reveal a discrete cellular mechanism of endosomal G protein activation

Many GPCRs initiate a second phase of G protein-mediated signaling from endosomes, which inherently requires an increase in G protein activity on the endosome surface. Gs-coupled GPCRs are thought to...

biorxiv.org
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