ADC dealmaking remains active in 2026, with median upfront payments rising sharply even as overall deal volume remains below 2025.
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Large-cap biopharma continued to concentrate in-licensing spending in oncology and biologic modalities through 2026 YTD.
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J.P. Morgan’s latest Biopharma and Medtech Licensing and Venture Reports, with data provided by DealForma, offer a comprehensive look at licensing, M&A, venture funding, and IPO activity in the first half of 2026.
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Median licensing payments varied significantly by development stage across 2024–2026 YTD.
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Large-cap biopharma continued to pay higher upfronts for later-stage assets in 2026 YTD.
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Big pharma’s sourcing from Chinese biopharma continued to accelerate in 2026.
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Big pharma’s sourcing from Chinese biopharma continued to accelerate in 2026.
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Large-cap biopharma continued to favor discovery-stage opportunities in 2026.
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A few large transactions drove cardiovascular dealmaking in Q3 2026. Partnership and M&A deal counts fell from Q2, while venture and IPO capital rose.
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APAC biopharma companies continued to capture a growing share of licensing upfront dollars in 2026.
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$100M+ biopharma licensing deals slowed in Q3 2026, but year-to-date activity remains close to 2025 levels.
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Biopharma M&A activity cooled in Q3 2026, while licensing upfront payments remained relatively steady.
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Deal flow across healthcare, therapeutics, and medtech continued to slow in Q3 2026.
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Autoimmune dealmaking shifted to larger checks in Q3 2026. IPOs returned, while venture funding cooled.
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Stifel remains optimistic on biotech into 2027, expecting renewed M&A, strong capital markets, and continued pharma demand to support the sector despite near-term macro and political headwinds, with market & transaction data provided in part by DealForma.
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Q3 2026 dealmaking cooled across every channel, with value falling faster than volume.
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In H1 2026, reverse merger and SPAC activity grew in breadth, not scale; more companies reached the public market, but each carried far less upfront value.
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During H1 2026, large-cap biopharma R&D partnering was defined by concentration and back-weighted economics. A small group of buyers drove most deals and dollars, led decisively by Eli Lilly.
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Large-cap biopharma M&A in H1 2026 turned narrow. One company dominated deal flow, one therapeutic area absorbed most of the capital, and a small group of names accounted for the rest.
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Antibody dealmaking shifted from licensing to buyouts in H1 2026, with ADCs and bispecifics at the center. Partnerships stayed big but paid less upfront. M&A surged. Venture held firm, and IPOs stayed thin.
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