Maria Jiang retweeted
TROFUSE-055 is a randomized phase 3 non-muscle invasive bladder cancer trial. It’s another trial exploring bladder surgery sparing approaches. This study tests the combination of SAC-TMT with Pembro (68% RR in advanced disease) followed by chemoradiation. The control is ChemoRT (+/- NAC). This study is distinct from EV309 where no chemoRT is given in the study arm. We will need many trials to identify the optimal approach. The role of chemoRT in ADC driven cCR is unknown. @OncoAlert
Maria Jiang retweeted
FDA grants Priority Review for the VOLGA trail, in which 3 neoadjuvant cycles of EV and a year of Perioperative durvalumab was given for patients with muscle invasive bladder cancer. Press release states an EFS and OS advantage. Data will be presented #ESMO26 @OncoAlert @myESMO @Annals_Oncology astrazeneca-us.com/content/a…
Maria Jiang retweeted
⚡️ @NEJM - Perioperative enfortumab vedotin + pembrolizumab improves outcomes in muscle-invasive bladder cancer.
In KEYNOTE-905:
• 2-year EFS: 74.7% vs 39.4% (HR 0.40)
• OS: HR 0.50
• pCR: 57.1% vs 8.6%
A potential new standard in cisplatin-ineligible patients.
#BladderCancer #Immunotherapy
nejm.org/doi/full/10.1056/NE…
Maria Jiang retweeted
We keep rediscovering the same truth—hormonal biology works. Estrogen returns in prostate cancer, this time via patches, with noninferior outcomes and potentially better tolerability. Not new—just better applied. Study in @NEJM by the #Stampede group/@MRCCTU
nejm.org/doi/full/10.1056/NE…
Maria Jiang retweeted
ctDNA data for radiotherapy (TMT) in muscle invasive bladder cancer shows 19/59 pts (32%) were ctDNA+ve at baseline (⬇️ than in NIAGARA 57%). 11/19 had ctDNA clearance with TMT. Those that didn’t clear had ⬆️ risk of systemic rather than local relapse, underlining TMTs role in local rather than systemic control. CtDNA helps. Congrats to the team. @OncoAlert
Maria Jiang retweeted
⚡️ ctDNA after bladder-sparing trimodality therapy in MIBC.
In 84 patients treated with chemoradiotherapy, detectable post-CRT plasma ctDNA strongly correlated with metastatic recurrence, but not with isolated local relapse.
Supports ctDNA as a marker of distant relapse risk.
@CCR_AACR #BladderCancer #ctDNA #MIBC
aacrjournals.org/clincancerr…
Maria Jiang retweeted
Perioperative Enfortumab Vedotin and pembrolizumab beats neoadjuvant chemotherapy & cystectomy in muscle invasive bladder cancer. We’re moving towards a bladder surgery sparing strategies using EVP. This is another step towards curing bladder cancer pfizer.com/news/press-releas…
Maria Jiang retweeted
1/2 KN905 Enfortumab Vedotin + Pembro continues to transform bladder cancer in spectacle fashion. In cisplatin ineligible operable disease it beats cystectomy with EFS HR 0.4, OS HR 0.5. pCR of 57% is much ⬆️ than anything before #ESMO25 pCR> 50% questions unselected surgery
Maria Jiang retweeted
Pleased to present at #ESMO25 the 16 year experience of tandem high-dose chemotherapy and autologous stem cell transplant for relapsed/refractory advanced stage germ cell tumours from @pmcancercentre .
Maria Jiang retweeted
The AlphaBet trial @PeterMacCC @TheLancetOncol release today @myESMO #ESMO25: combining Lu-177 PSMA-I&T + Ra-223 in men with metastatic castration-resistant #ProstateCancer is safe, feasible, and active.
✅ No dose-limiting toxicities
💪 PSA-50% decline in 55%
🧬 Supports future α+β theranostic combos.
🔗 authors.elsevier.com/a/1lyc6…
Congrats @LouiseKostos: what an amazing PhD!
Thank-you to @PCF_Science @pros_tic @Bayer for funding & support, co-senior author @AzadOncology, all the co-authors, wider village of contributors and most importantly our patients and their families for participating.
Maria Jiang retweeted
🚨Just in @NatureMedicine 👉 results from the Ph 3 AMPLITUDE trial: adding niraparib to abiraterone ⬆️outcomes in HRR-altered mHSPC #prostatecancer 👉 RPFS ⬆️: BRCA 1/2 HR 0.52, P < 0.0001; ITT HR 0.63, P =0.0001 Open link👉 bit.ly/47lt5Oj @PCFnews @OncoAlert @urotoday
Maria Jiang retweeted
Five great UC studies #ESMO25 - 1/5 Disitimab Vedotin (HER2) +Toripalimab vs platinum chemo in 1st line HER2+ve UC is positive for PFS/OS. Press release says ‘This reshapes the global treatment landscape of UC,” which sounds v.good. Can it be better than EVP? Are sfx different?
Maria Jiang retweeted
📬 The Milan Consensus paper on Clinical CR definition & Endpoints for next-gen bladder-sparing trials is out in @JCO_ASCO @ASCO | following the @SanRaffaeleMI #GURetreat24
Co-sponsored by @IBCG_BladderCA @GTumors
It was a tremendous multidisciplinary effort involving friends/KOL from various fields, pt advocates @BladderCancerUS @WorldBladderCan Pharma Industries & @FDA #EMA proving insights
✅ cCR should be rigorously based on imaging + biopsy + urinary citology
✅cCR still immature as primary endpoint for registration trials (good for esploratory studies)
✅ EFS good for registration trials
✅ EFS should capture ANY type of event including HG bladder relapses
🛜 role of biomarkers (ctDNA/utDNA) still to conceive in this clinical setting but likely to become the next 🧩
@MyUniSR @UroDocAsh @SpiessPhilippe @sonpavde #MattGalsky @#bladdercancer #endpoints #clinicalresearch @urotoday @OncLive @OncoAlert @Larvol
Maria Jiang retweeted
JUST IN: Tar200 now @US_FDA approved based on SunRise-1 phase 2 trial in BCG unresponsive NMIBC.
-Intravesical form of Gemcitabine
- CR: 82.4%/grade ≥3 AE 12.9%
- DFS 70.2% at 12m
- 51% of CRs with DOR ≥ 12 months.
Maria Jiang retweeted
Association of patient and physician characteristics with androgen-deprivation-therapy intensification in patients with de novo hormone-sensitive metastatic prostate cancer: A population-based study
acsjournals.onlinelibrary.wi…
Population-based study in Ontario 🇨🇦evaluated factors influencing the use of treatment intensification in older men with de novo metastatic hormone-sensitive #ProstateCancer , finding that only 24% received additional therapy beyond androgen deprivation. Physician specialty significantly impacted treatment patterns, with patients managed by radiation oncologists less likely and those seen by medical oncologists more likely to receive intensification, while older age strongly decreased the likelihood of intensified therapy.
These results highlight that both patient and physician characteristics drive variation in care, emphasizing the need for targeted interventions to improve uptake of guideline-recommended, life-prolonging therapies.
@DavidDan_Ngn
@DrRajSat
@KhattiA
@AHirdMD
@Soum_Roy_RadOnc
@DrMichaelOng
@DiMariaJiang
@drgotto
@GSK_UofT
@RodBreau
@lalaniMD
@WallisCJD
@OncoAlert 🚨
@Silke_Gillessen @AOmlin
@nataliagandur @bavilima
Maria Jiang retweeted
Congratulations Shilpa @shilpaonc and Ben @maughanonc for leading these efforts and congratulations to the team for this work in the prestigious @EUplatinum European Urology. @PGrivasMDPhD @EAntonarakis @bilenma @LiangChengMD @LDyrskjot doi.org/10.1016/j.eururo.202…
🩸🧬Liquid biopsy is no longer future!
Minimally invasive, biomarker-driven care!
@EUplatinum @isliquidbiopsy @maughanonc @EAntonarakis @LDyrskjot @PGrivasMDPhD @bilenma @dr_coops @shilpaonc @OncoAlert @Uroweb @Albert0Briganti
doi.org/10.1016/j.eururo.202…
Maria Jiang retweeted
IMVIGOR011: Atezo vs placebo in ctDNA+ve bladder ca (including -ve becoming +ve) post cystectomy hit OS/PFS. It also tracks outcomes in the ctDNA-ve, supporting a ctDNA adjusted approach. It’s been a long journey for atezo in UC but it has +ve OS at last natera.com/company/news/imvi…
Maria Jiang retweeted
Perioperative EVP shows ⬆️ EFS,OS & pCR vs cystectomy alone in high risk cisplatin ineligible MIBC (KN901). Highly active systemic vs surgery will rescue many patients with aggressive micrometastatic disease. CRs for EVP=30% in M1 but should be ⬆️ in MIBC biospace.com/press-releases/…
Maria Jiang retweeted
Just came online in @TheLancet 👉Our two papers on improved OS with Enzalutamide + Talazoparib in mCRPC #ProstateCancer in all-comer & HRRm patients (Median OS and HRs👇). Weblinks to the papers👉 bit.ly/4lXkLtB and bit.ly/4nNIyOh @PCFnews @urotoday @OncoAlert
Just in👉Two @TheLancetOncol papers on patient-reported QOL results in ph3 TALAPRO-2 trial👉in all-comer & HRR deficient mCRPC #ProstateCancer pts👉Improved OS without compromising QOL👇Links: bit.ly/3DWHlSR & bit.ly/3E3SSQi @urotoday @OncoAlert @PCFnews 👇
Maria Jiang retweeted
ctDNA can help guide adjuvant decision making in MIBC
In pts with undetectable ctDNA after NAC + cystectomy, no definitive benefit for adjuvant ICB
authors.elsevier.com/c/1lMET…
@MattGalsky @TischCancer @IcahnMountSinai @Uromigos @BladderCancerUS @urotoday @WorldBladderCan @OncLive




















































