Alanna Husch

Post-COVID-19 Femoral Head Osteonecrosis Exhibits Mast Cell Clusters, Fibrosis, and Vascular Thrombosis: Key Pathological Mechanisms in Long COVID-19 Bone Degeneration 🔥For many a new #LC presentation needing THR(Total Hip Replacement)😲 ➡️'Оsteonecrosis of the femoral head (ONFH) is a common condition in hip surgery, which is characterized by the death of bone cells due to disruption of the blood supply and ultimately irreversible destruction of the hip joint.' ➡️'As a result of the COVID-19 pandemic, a significant INCREASE in the incidence of ONFH has been identified.' ➡️'Data suggest that the key morphological biomarkers that trigger the main molecular and cellular mechanisms in the development of post-COVID-19 ONFH are clusters of mast cells, extensive areas of fibrosis, numerous arterial and venous thrombi, and giant cell granulomas.' ➡️'At the same time, the leading players are probably mast cells, which, when interacting with the COVID-19 virus, undergo excessive hyperplasia, activation and degranulation.' ➡️'The factors released by mast cells, in turn, increase inflammation, affect bone and cartilage metabolism, cause blood vessel dysfunction and thrombosis, and contribute to the development of fibrosis, thereby stimulating and facilitating the development of osteonecrosis of the femur.' ➡️'Our results demonstrate that the accumulation and activation of mast cells is a feature of the pathogenesis of post-COVID-19 osteonecrosis and can be considered as a diagnostic sign of this disease. ‼️Anybody needing a THR today, should be screened! It may only be the tip of a far broader #LC problem! mdpi.com/1873-149X/32/3/36