Studying effects of maternal immune activating exposures on fetal brain development and offspring behavior. 👍🏻microglia, the placenta, and sex differences.

Mass General Hospital
Joined October 2018
Loved hanging out with a wonderful and accomplished @MySMFM Resident Scholar, Tanner Fincher! She will be a fantastic MFM fellow and future colleague!!
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Edlow Labsgiving! So fun!🍗🦃🥧. And joined by our guest speaker and collaborator Kate Dannheim to talk about the placenta. very thankful for this group ❤️
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So fun to be with the @MySMFM board to vision about the next 3-5 years! Also got hair and makeup done for a soon-to-be revealed @MySMFM project! Not sure if it’s a secret but we are excited to bring you some educational Content soon! Hint: 💉💉
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Halifax things @PNIRS #PNIRS24
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Then, in personalized microglial models created in collaboration with @royperlis lab, we recapitulated these deficits in vitro using synaptosome phagocytosis assays. This work suggests that synaptic pruning by microglia is a key mechanism to investigate that may underly (cont'd)
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to see if we could use fetal placental Macs (Hofbauer cells) from HUMAN placentas to model potential impacts of maternal SARS-CoV-2 infection on fetal brain microglia. ScRNA-seq revealed Hofbauer cell programs c/w dysregulated macrophage phagocytosis after SARS-CoV-2 exposure..
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Excited to attend my 1st ever @PNIRS Annual Meeting in Halifax! Join me, Marisa Spann @N3early and Brittany Howell Thursday AM for our symposium “Early Immune Predictors to Identify Offspring at Risk for Neurodevelopmental Sequelae”!
#Halifax is thrilled to welcome the PsychoNeuroImmunology Research Society to Halifax for the @PNIRS 2024 Annual Meeting @hfxconventions #WelcomeToHfx 🌊
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Replying to @bostonvaginadoc
@bostonvaginadoc / Caroline Mitchell Lab representing exciting work on how b-cell depleting therapy impacts endo cervical microbiome! Boston cohort represents at @ASReproImmuno 2024! @MghObgyn @MGHVCRBResearch
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Amazing talk in the sex differences session by Sahar Khoshravesh @IrinaBurd lab about impact of estrogen on placental structure and immune cell populations in non-human primates
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