Assistant Professor at @ubcpathology and Scientist at @BCCancer studying the evolving relationships between lung tumours and the immune response.
Vancouver, BC, Canada
Joined July 2018
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Our paper is out! Excited to be part of such an amazing team unravelling the complexities of lung tumour/TME coevolution in #TRACERx Big thanks to all those involved in the project and who supported our work. Presented by @CharlesSwanton at #AACR24 Check out our Tweetorial below.
What is the role of the TME in lung cancer evolution? We are excited to share our new TRACERx paper “Spatial Architecture of Myeloid and T Cells Orchestrates Immune Evasion and Clinical Outcome in Lung Cancer” at #AACR24, out in @CD_AACR today rb.gy/q484j9 Tweetorial👇
We discuss the importance of B cells in mounting an effective anti-tumour response against these antigens, particularly with immunotherapy.
A team of researchers led by postdocs @EnfieldKatey, @jboumelha and @KevinWNg found that fragments of ancient viral DNA that can be ‘reawakened’ in cancerous cells are a potential target for cancer immunotherapy treatments.
@JulianDownward | @SwantonLab crick.ac.uk/news/2023-04-15_…
Katey Enfield retweeted
Excited to share our TRACERx nature publication on circulating tumor DNA (#ctDNA, #MRD) detection in resectable lung cancer led by @AbboshChris, @Afrankell, @juditkisistok, Thomas Harrison, Aaron Garnett, @nbirkbak and @NickyMcGranahan 👇👇👇 Tweetorial🧵
nature.com/articles/s41586-0…
A nice summary of our study in the @BBC!
Katey Enfield retweeted
Our review @WillHilliam @LimEmilia @EvaGronroos @CharlesSwanton is out in this stellar issue of @CellCellPress! We address how our environment can promote tumours from otherwise dormant oncogenic cells and ask "Are these processes preventable?"
authors.elsevier.com/c/1gvdd…
Katey Enfield retweeted
Dive into the data behind the landmark #TRACERx study 🔍
📅 Nine years of research
👥 800+ patients
️🧑🔬 250 investigators
🏥 13 hospital sites.
Read more about the study and what it means for future lung cancer patients: cruk.ink/3KtCCHv
@TheCrick @UCL
Katey Enfield retweeted
Today, @nature and @NatureMedicine are proud to publish amazing new insights into lung cancer evolution from the #TRACERx consortium. Updated collection: nature.com/collections/haffg… Great author threads👇
Katey Enfield retweeted
Cachexia is a devastating condition in patients with cancer. Our study on cancer cachexia in #TRACERx is out today in @NatureMedicine led by @Othman_Al_Sawaf, @MariamJHanjani, @SwantonLab:
nature.com/articles/s41591-0…
Key results in a brief 🧵
Katey Enfield retweeted
Excited to share our recent @SwantonLab @NickyMcGranahan & @MariamJHanjani lab work on the genomic evolution of non-small cell lung cancer metastases in #TRACERx, out @Nature
nature.com/articles/s41586-0…
A quick thread [1/13]
Katey Enfield retweeted
We're thrilled to share work on tumour evolution in 421 TRACERx lung cancer patients by @AFrankell @Michi_Dii @drmaiseb @LimEmilia @TakKarasaki @Ward__Sophie RajuVeeriah @ColliverEmma @AMIHuebner @abi_bunkum @ZaccaSimo @MariamJHanjani @NickyMcGranahan🧵⬇️
nature.com/articles/s41586-0…
Katey Enfield retweeted
Delighted to present our paper on the evolutionary characterisation of lung adenocarcinoma (LUAD) morphology in the TRACERx cohort, published @NatureMedicine led by @TakKarasaki @davidallanmoore @NickyMcGranahan @MariamJHanjani @SwantonLab
nature.com/articles/s41591-0…
Katey Enfield retweeted
Very excited that our paper on B cells and immunotherapy in lung cancer is out today @Nature . A privilege to work alongside @KevinWNg @EnfieldKatey on this. Give it a read ✨✨
nature.com/articles/s41586-0…
Katey Enfield retweeted
Our paper together with @SwantonLab @CharlesSwanton ‘Genomic-transcriptomic evolution in lung cancer and metastasis’ comes out today @Nature. nature.com/articles/s41586-0… Read all about it 🚨👇 1/9
What a privilege to be part of this exciting cross-lab collaboration with outstanding scientists @KevinWNg @jboumelha. All made possible thanks to our talented collaborators, funders, patients, and mentorship from @CharlesSwanton @JulianDownward and George Kassiotis @TheCrick
Excited to share our work finding an unexpected role for tumour-reactive B cells in immunotherapy response in lung cancer, led by @KevinWNg @jboumelha @EnfieldKatey, now published in @nature with @CharlesSwanton and George Kassiotis labs @TheCrick
nature.com/articles/s41586-0…
Katey Enfield retweeted
Today our important study on air pollutants in the promotion of lung cancer has been published in @Nature led by @WillHilliam @LimEmilia @DrClareWeeden @SwantonLab ...Thread below🧵nature.com/articles/s41586-0…
Katey Enfield retweeted
[Scientific Officer/Technician] Join us in #TRACERx! Great opportunity within the phenomenal TRACERx study of the @CRUKLungCentre at @uclcancer and @TheCrick with outstanding collaborators @CharlesSwanton @SwantonLab @MariamJHanjani @NickyMcGranahan
👉 ucl.ac.uk/work-at-ucl/search…
Katey Enfield retweeted
Excited to share Refphase- a new R package for identifying haplotype-specific SCNAs and parallel copy number evolution in cancer. bioRXiv- tinyurl.com/525pp6av Tool- bitbucket.org/schwarzlab/ref… More below 👇 @tbkwatkins @rfschwarz @MattHuska @CharlesSwanton @NickyMcGranahan 🖥️🧬
I'm excited to finally share the preprint for our multi-region reference phasing algorithm Refphase for detecting haplotype-specific copy-numbers in cancer.
biorxiv.org/cgi/content/shor…
Thanks to @tbkwatkins @ColliverEmma @MattHuska Tom Kaufmann and many more. @bifoldberlin @UKKoeln
Katey Enfield retweeted
Blistering start to @AACR #AACR2022 masterclasses on exhaustion @EJohnWherry , neoadjuvant CPI T cell response @SmithImmunology, somatic muts in healthy cells Sir Michael Stratton & rooftop w/ @SwantonLab check out posters & talks from the @CRUKLungCentre @uclcancer from today
Very proud to be a part of the exciting collaborative research featured in the exhibition #OutwittingCancer
You can check it out for free @TheCrick or visit online #WorldCancerDay2022 crick.ac.uk/whats-on/exhibit…
Katey Enfield retweeted
It’s exciting to finally share and discuss our study on additive cytotoxicity, a crowd-based killing mechanism of cytotoxic T cells (CTL) to target cancer!
Highlights in the thread, free access @NatureComms here: nature.com/articles/s41467-0…
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#immunology #microscopy