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Adam the contrast was the point. Two different bad/fatal diseases yet very different response from the field to advances. We do not have a functional cure for many cancers but HR < .7 in any cancer is described as practice changing in oncology. Neurology seems underwhelmed by the same degree in disease change.
Of course cancer is not one thing and I could have been more precise- CLL is not good but now mostly not fatal, due to many advances from Lilly and our peers HR+ HER - breast cancer has long survival now yet GI cancers are mostly unsolved and survival curves are terrible.
You know what else is terrible? Almost every neuro-degenerative disease including AD and we (including the media) need to discuss it that way. Unfortunately I’ve witnessed end of life journeys up close in both diseases, while different horrors present themselves in each I’d say they are both pretty bad. Advancement 30%+ at a time should change practice and routinely be offered to patients and families. Oncology does this Neurology doesn’t.
$LLY Kisunla is an Alzheimer's drug. It's not a cancer drug. Different diseases, different trajectories, different patient population with different needs, different benefit-risk profile.
@DaveARicks, speaking to @bradloncar, points to the hazard ratio from Kisunla's Phase 3 studies and says, "If this was a cancer drug, it would be a giant drug!"
Ok, but it's not.
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The students ICE is disappearing seem such a random selection. I wonder how they decide who to go after. Is it driven by denunciations? That would be even more dystopian.
Interesting choice to put your (CEO) picture in the Letter to Shareholder section of the Annual report...
Bruker $BRKR is poised to have the fastest growth in top and bottom line among pairs in the coming 2-3 years with proteomics solution being the fastest segment.
I have similar experience with IP-MS in biofluids. We directly digest with high concentration of trypsin without detergent. In certain cases, short digestion with Rapizyme at high temperature without detergent.
[ASAP] Impact of Surfactants on Cumulative Trypsin Activity in Bottom-Up Proteome Analysis dlvr.it/T9KGVy
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I’m gonna give 10 random people that repost this and follow me $25,000 for fun (the $250,000 my X video made)
I’ll pick the winners in 72 hours
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Munger lived such an incredible life, mainly because he did whatever he wanted and said whatever he wanted without fear of others disagreeing.
"I did not intend to get rich. I just wanted to get independent."
teapawt.net/exec_sum/status/172960…
Our manuscript on one of the projects I worked on during my postdoc went online!
SHIP1 modulation and proteome characterization of microglia biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Thanks Focused Compounding for being my top podcast on @Spotify this year. I loved all 2,471 minutes of it. #SpotifyWrapped open.spotify.com/show/7cRZco…
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This was such a brilliant video I subtitled it so more people can watch it. Beijing students' response last night to accusations that there are 'foreign forces' at play in this weekend's protests
'The foreign forces you are talking about – are they Marx and Engels?'
On Nov 23, when a fire broke out in #Urumqi , people’s doors were locked from outside. Fire truck couldn’t get closer either( see my previous tweet). The latest figure says 44 were burnt to death, including a 3 y/o kid. That’s one of the reasons for today’s protests.
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Families in a hi-rise in China were locked into their apartments as their building caught fire. Urumqi, in Xinjiang Province
They burned alive as they couldn't escape and no one could get to them in time
This is directly on the CCP and Xi's Zero-Covid lockdown strategy
An important paper came out of my PhD lab
Mitotic phosphorylation inhibits the Golgi mannosidase MAN1A1 cell.com/cell-reports/fullte…
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The Golgi apparatus: Site for convergence of COVID-19 brain fog and Alzheimer’s disease? See our hypothesis.
pubmed.ncbi.nlm.nih.gov/3627…
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BREAKING NEWS:
The Royal Swedish Academy of Sciences has decided to award the 2022 #NobelPrize in Chemistry to Carolyn R. Bertozzi, Morten Meldal and K. Barry Sharpless “for the development of click chemistry and bioorthogonal chemistry.”
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Our @UMich_MCDB department is now accepting applications for our PhD program!
DUE Dec 1st!
Financial support includes stipend, tuition, & health insurance for you, spouse & dependents.
Click here for details: lsa.umich.edu/mcdb/graduate-…
Or DM me!
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Really proud of @StJudeResearch for recognizing the challenges postdocs face and stepping up their salaries. Now starting at $70k🎉 And lots of amazing labs and mentors, come join us! bit.ly/3B2Ty48
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GRASP55 regulates the unconventional secretion and aggregation of mutant huntingtin
sciencedirect.com/science/ar…
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Identification of secreted proteins by comparison of protein abundance in conditioned media and cell lysates biorxiv.org/content/10.1101/…
Erpan retweeted
My latest research piece is a full analysis of Floor & Décor $FND. Head on over to EquiCompound.com for a free, downloadable copy of the writeup. If you value this work, feel free to sign up for my mailing list for future research.
equicompound.com/floor-and-d…



























