@FKlein_Lab

Laboratory of Experimental Immunology @UKKoeln - studying the antibody response to HIV-1, HCV, HCMV, SARS-CoV-2 and other infectious pathogens

 Cologne - Germany
klein-lab.de/
Joined December 2021
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  • Following70
  • Followers1.6K
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Gründungssymposium des Centrums für Infektionsmedizin (CIM): Das CIM der #Uniklinik #Köln bündelt Sachverstand in der Infektionsmedizin. Gearbeitet wird an Best-Practice-Modellen für Patientenversorgung, translationale Forschung & Aus- und Weiterbildung. uk-koeln.de/uniklinik-koeln/…
Gründungssymposium des Centrums für Infektionsmedizin, Foto: Michael Wodak

ALT Gründungssymposium des Centrums für Infektionsmedizin, Foto: Michael Wodak

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Wir freuen uns auf dieses spannende Projekt gemeinsam mit @LabSchultze @FKlein_Lab @fabian_theis @marylyn_addo @HeroldLab @MartinaSester @alena_buyx u.v.m. zu cutting edge KI #SwarmLearning in der klinisch-immunologischen Forschung am Bsp. von COVID19. Danke an @VolkswagenSt
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Die drei Else Kröner #ClinicianScientist Professuren 2023 erhalten ... PD Dr. Natascha Köstlin-Gille, @uniklinik_hd PD Dr. Dr. Philipp Schommers, @UKKoeln u. Dr. Jonas C. Schupp, @MHH_life Herzlichen Glückwunsch! 🥳 @jonas_schupp @SchommersP #EKFS ➡️ ow.ly/85CS50QfUeo
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Wie verändert sich die Antikörperantwort gegen #SARSCoV2 mit der Zeit und wie bereitet sich das Immunsystem mit klugen Strategien auf neue Varianten vor? Die AG von Prof. Klein @FKlein_Lab hat dazu Studien in @ImmunityCP und @SciImmunology veröffentlicht. uk-koeln.de/uniklinik-koeln/…
V.l.n.r. Prof. Dr. Florian Klein, Dr. Christoph Kreer, Dr. Timm Weber, Svea Rose, Dr. Matthias Zehner, Michael Korenkov Foto: Michael Wodak

ALT V.l.n.r. Prof. Dr. Florian Klein, Dr. Christoph Kreer, Dr. Timm Weber, Svea Rose, Dr. Matthias Zehner, Michael Korenkov Foto: Michael Wodak

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We are very happy to share our latest publication out in @ImmunityCP! Here we investigated how somatic hypermutation impacts SARS-CoV-2 neutralizing antibodies (authors.elsevier.com/a/1iAVY…). Thanks a lot to our dear 🇮🇱 friends and collaborators @DiskinLab
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Highlights include: A fraction of mutated antibodies neutralizes Wu01 independently of the acquired mutations. Germline VH1-58 mAbs neutralize Alpha, Beta, and Delta but require mutations for BA.1/BA.2.
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Previously acquired bystander mutations can increase B cell diversity against variants. Transferring a single bystander mutation restores the neutralizing activity of tixagevimab against BA.1/BA.2.
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Congratulations Elena, Eva, and Rolf!
Uniklinik Köln@UKKoeln29 Nov 2023
Patient von #Leukämie und #HIV geheilt: Für die Heilung des „Düsseldorfer Patienten“ wurde ein interdisziplinäres Forschungsteam mit Beteiligung von Forschenden der #Uniklinik #Köln heute mit dem Preis der Deutschen #Hochschulmedizin 2023 ausgezeichnet. uk-koeln.de/uniklinik-koeln/…
Eine der Erstautorinnen der Fallstudie: Dr. Elena Knops, Foto: Michael Wodak

ALT Eine der Erstautorinnen der Fallstudie: Dr. Elena Knops, Foto: Michael Wodak

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Congratulations Timm, Sabrina, and Svea to shed light on how #SARS-CoV-2 vaccination and breakthrough infections shape our antibody response. Now @SciImmunology. Thanks to all study participants and co-authors! science.org/doi/10.1126/scii…

Enhanced SARS-CoV-2 humoral immunity following breakthrough infection builds upon the preexisting...

Repeated SARS-CoV-2 exposure results in selection of preexisting broadly reactive B cell clones generated after Wu01 vaccination.

science.org
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🎉🏆Sieben Forschende der #UniKöln sind unter den meistzitierten Wissenschaftler*innen weltweit 🌍. Herzlichen Glückwunsch an unsere zwei Biolog*innen und fünf Mediziner, die zu den einflussreichtsen 1% ihres Faches gehören. 🧪🩺 #HighlyCited2023 Mehr 👇 uni.koeln/NDTFX
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Excited to share our latest publication @ImmunityCP: "Analysis of the Human B Cell Response to HCMV in Top Neutralizers from a cohort of 9,000 Individuals"! Congrats to @zehner_matthias, @Ashurov_Art and Mira and thanks to all collaboration partners! sciencedirect.com/science/ar…
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Just out: Our study on the dynamics of HIV-1 neutralization in over 2.300 individuals @NatureMedicine. Congratulations to Philipp (@SchommersP) and thanks to all our collaboration partners from around the world. nature.com/articles/s41591-0…

Dynamics and durability of HIV-1 neutralization are determined by viral replication

Nature Medicine - Human immunodeficiency virus type 1 (HIV-1)-neutralizing responses can persist for several years, even at low antigen levels, suggesting that an HIV-1 vaccine may be able to...

nature.com
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Congratulations Christoph, Cosimo and Seda! Thank you very much Aleksandra Walczak, Thierry Mora, Andreas Beyer and all other co-authors for this great collaboration!
Christoph Kreer@ChristophKreer13 Nov 2023
Happy to share the publication of our joined project between @FKlein_Lab and the Walczak/Mora Lab, where @wolphysics, Seda and myself investigated the probabilities of developing HIV-1 neutralizing antibody sequence features: disq.us/t/4k4i2j7
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Happy to share the publication of our joined project between @FKlein_Lab and the Walczak/Mora Lab, where @wolphysics, Seda and myself investigated the probabilities of developing HIV-1 neutralizing antibody sequence features: disq.us/t/4k4i2j7
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Check out how we applied our @FKlein_Lab antibody isolation workflows to target drug resistent bacteria in this fantastic cooperation with @SimonisLab, @JanRybniker and @DZIF_ colleagues…
Cell@CellCellPress2 Nov 2023
Now online! Discovery of highly neutralizing human antibodies targeting Pseudomonas aeruginosa dlvr.it/SyHXKz

Discovery of highly neutralizing human antibodies targeting Pseudomonas aeruginosa

Drug-resistant Pseudomonas aeruginosa poses an emerging threat to human health with an urgent need for alternative therapeutic approaches. Elucidation of the human immune response to the P. aerugin...

cell.com
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We are happy to announce that our lab is the first on campus @UKKoeln to be awarded the highest level of certification (Green) by @My_Green_Lab! bit.ly/greenlabcert
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Excited about #AntibodyBasedTherapies workshop of the @DZIF_ bridging topic hosted @UKKoeln. Amazing talks by representatives from academic research, clinic & industry all coming together to advance the development, production & clinical testing of monoclonal antibodies.
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Exciting topics at the @Covim_Network meeting on SARS-CoV-2 immunity in Berlin. Thankful to all the speakers and participants of the Collaborative Immunity Platform of the #NUM!
Leif Erik Sander🇺🇦@Sander_Lab6 Jun 2023
Toller erster Tag des @Covim_Netzwerk Symposiums in Berlin mit interessanten Diskussionen & spannenden Vorträgen zur SARS-CoV-2 Immunität @SawitzkiLab @FKlein_Lab @kischober @marylyn_addo @c_drosten @KUberla @AndreasJThiel @BeateKampmann @c_gaebler @h_gruell @KurthGroup uvm
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Our multicenter #SARSCoV2 seroprevalence study with 1,411 participants is now published in @NatureComms. Thanks to VIRAL NRW network, @UKKoeln, @UniklinikDUS, @UK_Muenster, @UniklinikEssen, @UniklinikBonn for the great cooperation! #COVID #Omicron nature.com/articles/s41467-0…

Impaired humoral immunity to BQ.1.1 in convalescent and vaccinated patients

Nature Communications - Dewald et al. show a high Spike-IgG seroprevalence (95%) in a multicenter study with 1,411 participants. They determined a substantially reduced serum neutralization against...

nature.com
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uk-koeln.de/uniklinik-koeln/…

Hohe SARS-CoV-2 Seroprävalenz

Multizentrische Studie des VIRus-ALlianz (VIRAL) NRW-Netzwerkes unter Beteiligung der Uniklinik Köln zeigt hohe SARS-CoV-2 Seroprävalenz

uk-koeln.de
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