Assuming identical baseline physiology between healthy controls & individuals with immunometabolic diseases can lead to the misinterpretation of functional assays & neuroimaging results. (Karabatsiakis, Holper & Scholkmann, 2026, karger.com/nim/article/33/1/…).

The antidepressant effects of psilocybin are linked to a normalization of astrocytes, i.e. a reduction in neurotoxic A1-like astrocyte reactivity (→ improved ATP/lactate/glutamate release, proliferation & mitochondrial function); Qiao et al., 2026, sciencedirect.com/science/ar…

New finding: 5-HT2AR β-arrestin signaling as a critical driver of prolonged antidepressant-like effects of psychedelics (He et al., 2026, nature.com/articles/s41593-0…) (Maybe linked to asrocyte regulation? -> sciencedirect.com/science/ar…) #psychedelics

The glymphatic-meningeal lymphatic system and autophagy as key aspects in ME/CFS (Nemat-Gorgani et al., 2026, tinyurl.com/43w69na2) #mecfs

Selective knockout of 5-HT2A receptors in cortical L5 pyramidal neurons prevents psilocybin-induced spine formation (Baker et al., 2026, nature.com/articles/s41593-0…) But no effect on head-twitch response (a rodent proxy of hallucination) #psychedelics

Similarities & differences between ME/CFS & fibromalgia: Murovska et al., 2025, link.springer.com/article/10… Immune dysregulation & neuroinflammation: cytokine abnormalities, natural killer cell dysfunction, viral reactivation, microglial activation, autoimmunity-like features)

A new hypothesis about #fibromyalgia: Gabbai & Carmi, 2026, pmc.ncbi.nlm.nih.gov/article… Impaired upstream regulation → redistribution of flow toward non-nutritive pathways → reduced capillary perfusion → intermittent tissue hypoxia → nociceptor sensitization → pain & tenderness

Global CBF increases logarithmically during infancy (Ouyang et al., 2026, nature.com/articles/s41467-0…).

Important new study on the effect of LSD on brain hemodynamics; McCulloch (@D_E_McCulloch) et al.: nature.com/articles/s41593-0… • Widespread CBF increase • Increased ICA flow • GCOR decrease Strong indication that we need to reinterpret past fMRI psychedelic neuroimaging studies...

How do protons move from respiratory complexes to ATP synthase? A new study (cell.com/biophysj/fulltext/S…) predicts that cardiolipin "functions as a highly efficient, quasi-two-dimensional nanoscale antenna that captures & rapidly channels protons directly to ATP synthase"

Changes in rotational (vortex-like) brain activity (spiral vorticity & spatial spiral vorticity dispersion) track the temporal unfolding of subjective intensity during the DMT experience (Sawicka et al., 2026, biorxiv.org/content/10.64898…)

A growth/differentiation factor-15 (GDF-15)-GDNF family receptor α-like (GFRAL) axis controls autoimmune T cell responses during neuroinflammation (Sonner et al., 2026, nature.com/articles/s41590-0…) Example of immunoception (the brain’s bidirectional monitoring & control of immunity)

Energy constraint on human health (Behnke et al., 2026, cell.com/trends/endocrinolog…): "The energy constraint model of human health provides an energy-based framework to address health/disease dynamics across the lifespan."

Baseline FDG-PET measures of brain glucose metabolism strongly predict 10-year cognitive decline & Alzheimer’s disease (Alhasan et al., 2026, sciencedirect.com/science/ar…). #brain #health