Florian Schueder (@FSchueder) header
Florian Schueder (@FSchueder) profile picture

Florian Schueder

@FSchueder

Spatial Omics | Super-resolution imaging | DNA Nanotechnology | #DNAPAINT #superresolution #spatialomics #microscopy Professor @schuederlab @EPFL

 Yale School of Medicine
florian-schueder.de
Joined July 2017
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Photo by Florian Schueder (@FSchueder)Photo by Florian Schueder (@FSchueder)Photo by Florian Schueder (@FSchueder)Photo by Florian Schueder (@FSchueder)Photo by Florian Schueder (@FSchueder)Photo by Florian Schueder (@FSchueder)Photo by Florian Schueder (@FSchueder)Photo by Florian Schueder (@FSchueder)Photo by Florian Schueder (@FSchueder)Photo by Florian Schueder (@FSchueder)
🚨 2 × PhD positions @EPFL @epflSV! Help us push the boundaries of fluorescence microscopy - DNA nanotech, custom optics & spatial omics in Lausanne 🇨🇭. Start Jan 2026. Send CV + motivation + 2 refs → [email protected] #PhD #Hiring #microscopy #SpatialOmics #DNAPAINT #FLASHPAINT
Image from Florian Schueder (@FSchueder)
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Please check out our newest work on fluorogenic speed imager probes, in which we combine the strengths of speed-optimized imagers and fluorogenic imagers. #SuperResolution #DNAPAINT #microscopy biorxiv.org/content/10.64898…
Image from Florian Schueder (@FSchueder)
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Please check out our latest publication on ATG2A in autophagosome biogenesis: elifesciences.org/reviewed-p…
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📄 New paper out! Please check out our latest publication, where we show how the gatekeeper protein InvE orchestrates hierarchical type III secretion in Salmonella Typhimurium via oligomeric assembly. #T3SS #DNAPAINT pnas.org/doi/10.1073/pnas.25…
Oligomeric assembly of the gatekeeper InvE orchestrates hierarchical type III protein secretion in...

Oligomeric assembly of the gatekeeper InvE orchestrates hierarchical type III protein secretion in...

Type III secretion systems (T3SS) are critical virulence machines in many Gram-negative bacteria, enabling hierarchical secretion of translocases f...

pnas.org
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🔬🧬 New in @NatureComms: Nanoscale 3D DNA tracing in non‑denatured cells maps the #3Dgenome at nm‑resolution and reveals Cohesin‑dependent dynamic loops! 🚀 #OpenAccess  nature.com/articles/s41467-0… EllenbergLab @JungmannLab #Genomics #SuperResolution
Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of...

Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of...

Nature Communications - A nanoscale 3D DNA tracing workflow visualizes Cohesin-dependent loops in single, structurally well-preserved cells. Computer simulations based on the tracing data give...

nature.com
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Big news: I’m joining @EPFL_en as Tenure-Track Assistant Professor of Life Science Engineering! Can’t wait to push super-resolution microscopy & spatial omics even further and build new collaborations in Lausanne. 🚀 #EPFL #SuperResolution #Microscopy #SpatialOmics #DNAPAINT
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The Stocker Lab’s @juanitamlg and colleagues discovered a new and highly interesting iron uptake mechanism in bacteria. biorxiv.org/content/10.1101/…
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I am very excited and deeply honored that our most recent work on #FLASHPAINT was highlighted as one of the methods to watch by @naturemethods' @rita_strack in the context of ‘spatial proteomics’ as Nature Methods' Method of the Year 2024.
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Please check out our (@PDClab @bewersdorflab) latest work on determining the location of the lipid transfer protein VPS13B within the Golgi complex. We use 7-color #FLASHPAINT imaging to locate VPS13B within the Golgi complex. @JCellBiol @YaleMed doi.org/10.1083/jcb.20231118…
Image from Florian Schueder (@FSchueder)
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Interested in super-resolution microscopy or DNA-PAINT? Dive into our chapter on 'In Situ Imaging of Proteins Using DNA-PAINT Super-Resolution Microscopy'—perfect for beginners! #DNAPAINT link.springer.com/protocol/1…
In Situ Imaging of Proteins Using DNA-PAINT Super-Resolution Microscop

In Situ Imaging of Proteins Using DNA-PAINT Super-Resolution Microscop

The spatial resolution of conventional light microscopy is restricted by the diffraction limit to hundreds of nanometers. Super-resolution microscopy enables single digit nanometer resolution by...

link.springer.com
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Please check out our (@bewersdorflab) latest work on #FLASHPAINT published in @CellCellPress. #FLASHPAINT builds on #DNAPAINT and allows for fast and fluorogenic, highly multiplexed super-resolution imaging. cell.com/cell/fulltext/S0092…
Unraveling cellular complexity with transient adapters in highly multiplexed super-resolution...

Unraveling cellular complexity with transient adapters in highly multiplexed super-resolution...

Development of FLASH-PAINT enables rapid and efficient visualization of cellular organelles, using a potentially unlimited number of labels.

cell.com
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#FLASHPAINT uses Transient Adapters to mediate the interaction between imaging probes and target molecules, thereby allowing the recycling of the more costly imaging probes.
Image from Florian Schueder (@FSchueder)
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I am very honored to receive the George Palade Award from the Microscopy Society of America (MSA) for my contribution to the field of microscopy and microanalysis in the life sciences. @MicroscopyToday #MSA #microscopy #GeorgePaladeAward microscopy.org/Society-Award…

MSA | Major Society Awards Recipients

microscopy.org
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NobelPrize in Physiology or Medicine for mRNA vaccines against COVID-19.
The Nobel Prize (@NobelPrize) profile pictureThe Nobel Prize
@NobelPrize2 Oct 2023
BREAKING NEWS The 2023 #NobelPrize in Physiology or Medicine has been awarded to Katalin Karikó and Drew Weissman for their discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19.
Image from The Nobel Prize (@NobelPrize)
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Please check out our latest paper on: Parkinson’s disease kinase LRRK2 coordinates a cell-intrinsic itaconate-dependent defence pathway against intracellular Salmonella @NatureMicrobiol @Yale @YaleMicroPath nature.com/articles/s41564-0…
Parkinson’s disease kinase LRRK2 coordinates a cell-intrinsic itaconate-dependent defence pathway...

Parkinson’s disease kinase LRRK2 coordinates a cell-intrinsic itaconate-dependent defence pathway...

Nature Microbiology - The Parkinson’s disease-associated leucine-rich repeat kinase 2 acts as a protein scaffold promoting mitochondria–Salmonella-containing vacuole tether formation...

nature.com
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Please check out our latest work about: Unraveling cellular complexity with unlimited multiplexed super-resolution imaging. #FLASHPAINT #DNAPAINT @YaleMed @YaleCellBio @bewersdorflab biorxiv.org/content/10.1101/…
Image from Florian Schueder (@FSchueder)
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Please check out our latest work in which we found evidence for a staggered organization of Titin in the flight muscle of drosophila using nanobodies and DNA-PAINT. @eLife @SchnorrerL @IBDMmarseille @MPI_Biochem #DNAPAINT elifesciences.org/articles/7…
Nanobodies combined with DNA-PAINT super-resolution reveal a staggered titin nanoarchitecture in...

Nanobodies combined with DNA-PAINT super-resolution reveal a staggered titin nanoarchitecture in...

The two Drosophila titin homologs Sallimus and Projectin display a precise tandem arrangement in the sarcomere that may explain how sarcomere length is regulated outside of vertebrates.

elifesciences.org
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Omics goes spatial epigenomics. cell.com/cell/fulltext/S0092… #MERFISH #SpatialOMICS @CellCellPress
Omics goes spatial epigenomics

Omics goes spatial epigenomics

Spatial omics techniques generate spatially resolved, comprehensive data about molecules that define the identity and function of cells in tissues. Epigenetic multiplexing approaches such as Multip...

cell.com
We found evidence for a staggered organization of Titin in the flight muscle of drosophila using nanobodies and DNA-PAINT.Please check out the results of our collaborative work.@SchnorrerL @PierreMangeol @EunicechyChan @IBDMmarseille @MPI_Biochem #DNAPAINT biorxiv.org/content/10.1101/…
Nanobodies combined with DNA-PAINT super-resolution reveal a staggered titin nano-architecture in...

Nanobodies combined with DNA-PAINT super-resolution reveal a staggered titin nano-architecture in...

Sarcomeres are the force producing units of all striated muscles. Their nanoarchitecture critically depends on the large titin protein, which in vertebrates spans from the sarcomeric Z-disc to the...

biorxiv.org
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Please check out our latest work about inducing forces and motion in DNA origami nanostructures via double- to single-strand transition: onlinelibrary.wiley.com/doi/…
Double‐ to Single‐Strand Transition Induces Forces and Motion in DNA Origami Nanostructures

Double‐ to Single‐Strand Transition Induces Forces and Motion in DNA Origami Nanostructures

A designed pulling mechanism making use of the entropic spring behavior of single-stranded DNA is presented. Controlled and reversible motion of two arms of a nanoscale DNA origami structure is...

advanced.onlinelibrary.wiley.com
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Our (@TeunHuijben @hrheydarian @SjoerdStallinga) latest work about detecting structural heterogeneity in single-molecule localization microscopy data is online. @NatureComms #superresolution #DNAPAINT #sms #smlm nature.com/articles/s41467-0…
Detecting structural heterogeneity in single-molecule localization microscopy data

Detecting structural heterogeneity in single-molecule localization microscopy data

Nature Communications - Particle fusion can improve signal-to-noise ratio in single molecule localization microscopy, but is limited by structural heterogeneity. Here, the authors demonstrate an...

nature.com
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