Fredrik Sjövall retweeted
🔥WHO published its 1st global research agenda for the world’s scientists to address the most urgent human health priorities to combat antimicrobial resistance
It outlines 40 research topics on drug-resistant bacteria,fungi& Mycobacterium TB
H/t @paimadhu
who.int/publications/m/item/…
Fredrik Sjövall retweeted
The MERCY trial of prolonged vs intermittent meropenem has been published, with a neutral (i.e. no difference) outcome on the primary measure. So is that it for prolonged infusions of antibiotics, can we just go back to intermittent dosing? 🧵(TL:DR no)
jamanetwork.com/journals/jam…
Fredrik Sjövall retweeted
TDM of antimicrobials in #ICU
💉life-saving drugs, difficult pharmacology
💉TDM: why do we need it?
💉uncertainties
concentrations to be targeted/where
adjusting dose if out of range
steady state: prerequisite?
outcomes when studying TDM
#FOAMcc
🖇️ bit.ly/3HD4qZj
Fredrik Sjövall retweeted
💉 Dexmedetomidine sedation in adults on MV in #ICU, rapid practice guideline: use suggested over other agents, if desirable effects including ⬇️ #delirium valued vs undesirable, including ⬆️ hypotension & bradycardia - weak recommendation (suggestion).
📎 bit.ly/3lo4f8G
Fredrik Sjövall retweeted
🔥🔥 Today, @esicm is launching the #AIRSPACE webapp - a tool to support #antibiotic decisionmaking at the bedside in the #ICU
esicm.org/airspace/
Honoured to have been leading this with @DrMCecconi and immensely grateful to everyone who contributed (1/x)
Fredrik Sjövall retweeted
Thank you @RussiaUN for your letter dated March 16.
Please see our suggested edits below.
#StandWithUkraine #RespectTheCharter
Fredrik Sjövall retweeted
The Intensive Care Platform Trial (INCEPT) research programme aims to prepare, initiate and run an adaptive platform trial assessing commonly used interventions in acutely ill intensive care unit (ICU) patients. Follow this account and incept.dk for updates!
Fredrik Sjövall retweeted
Jeg stiller i dag et simpelt spørgsmål via @Altingetdk. Det er ikke let at besvare for den enkelte eller for samfundet, men det er nødvendigt at stille. Det er nødvendigt at tage de svære beslutninger når der er tid til det, når det ikke er akut. altinget.dk/artikel/overlaeg…
Fredrik Sjövall retweeted
#LIVES2021
@ESICM will be launching #AIRSPACE - a web application to be used on smartphones, tablets or desktop computers - bringing all the information for #antimicrobial decision making to the #intensivecare clinicians at the bedside 24/
@DrMCecconi @DrStefan2 @JMellinghoff
Fredrik Sjövall retweeted
Don't forget to check out the On-Demand recordings of the #LIVES2021 meeting #VOD
Hours of high-quality presentations available for you!!
👉 lives2021.e-lives.org/sessio…
Fredrik Sjövall retweeted
Trump's latest bout of gaslighting scientists has pushed the NEJM editors to explicitly recommend leadership change. unprecedented but appropriate. #BidenHarris2020
Fredrik Sjövall retweeted
#music thought of the day: A jazz guitarist plays 100,000 chords and makes 3 people happy. A rock guitarist plays 3 chords and makes 100,000 people happy.
Fredrik Sjövall retweeted
The largest ICU trial in the world began today in Wellington - the study of liberal versus conservative oxygen therapy. More information here:
anzics.com.au/current-active…
#MegaROXtrial
Fredrik Sjövall retweeted
We hope to solve this rapidly with the Rapid COVID COAG trial. @sholzberg @Lbkreuziger @fniainle @MiddeldorpS @AggieLeeMD
clinicaltrials.gov/ct2/show/…
Fredrik Sjövall retweeted
To the self proclaimed experts going on TV making miracolous claims that "this treatment has saved this patient" without evidence from trials reflect: you would not go on TV claiming the weather is good today because you wished for it, please stop now. Misinformation causes harm.
Fredrik Sjövall retweeted
I still don't know if remdesivir works but I know all around this drug is weird. Let's see (thread)
Fredrik Sjövall retweeted
Ok, I have to say something, especially as I keep getting pulled into in these posts. COVID-19 causes ARDS. I keep hearing the refrain that it is not ARDS because “the compliance is normal.”
Fredrik Sjövall retweeted
COVIDcp.org is a platform for collaborating on RCTs to find treatments faster. What will incentivize PIs to share their protocols? Still refining website, send feedback to @BetsyOgburn or here: datamethods.org/t/covid-19-r… And if you’re a PI, please submit your protocol!
Fredrik Sjövall retweeted
Thank you @IDSAInfo for a robust review of the evidence. Any other guideline that suggested the use of drugs without evidence and potential for harm has been irresponsible and has put patients at risk. Let's work together to research what works and what does not #PrimumNonNocere
NEW: IDSA Guidelines on the Treatment & Management of Patients with COVID-19 Infection. These evidence-based rapid guidelines, updated in real-time, will address pressing clinical questions related to caring for patients w/ COVID-19: bit.ly/2y93qes #COVID19Guidelines
