@FairlieGroup

The Fairlie group works at the interface of chemistry, biology and disease.

 Brisbane, Australia
fairlie.imb.uq.edu.au/index.php
Joined May 2012
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  • Following20
  • Followers265
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Sulfated bile acid is a host-derived ligand for MAIT cells. Ito E, Inuki S, Izumi Y, Takahashi M, Dambayashi Y, Ciacchi L, Awad W, Takeyama A, Shibata K, Mori S, Mak JYW, Fairlie DP, Bamba T, Ishikawa E, Nagae M, Rossjohn J, Yamasaki S. Sci Immunol. 2024 Jan 26;9(91):eade6924.
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Professor David Fairlie awarded NHMRC Development grant for developing a new type of drug for inflammatory lung disease. #medicinalchemistry #lunginflammation #allergicasthma #pulmonaryfibrosis #COPD #FairlieLab
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New paper published: "HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus inflammatory responses in macrophages". January 17, 2023 120 (4) e2212813120 doi.org/10.1073/pnas.2212813…

HDAC7 is an immunometabolic switch triaging danger signals for engagement of antimicrobial versus...

The immune system must be able to respond to a myriad of different threats, each requiring a distinct type of response. Here, we demonstrate that t...

pnas.org
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Welcome back to Damica Laurie who is returning to the Fairlie Group as a PhD student. Damica recently completed her Honours Degree (achieving First Class Honours) with us.
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FairlieLab retweeted
CIPPS@ARC_CIPPS1 Dec 2022
That’s a wrap on #CIPPS2022 👏 Thank you to everyone who made it such a fantastic meeting! We feel so inspired by the great peptide and protein science that was shared and we can’t wait to see what’s next 👀
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FairlieLab retweeted
CIPPS@ARC_CIPPS29 Nov 2022
Now we have @FairlieGroup speaking about strategies for programming peptides for cell permeability and bioavailability If we could reliably get peptides into cells and send them to specific targets, the application possibilities would be endless! #CIPPS2022
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FairlieLab retweeted
CIPPS@ARC_CIPPS28 Nov 2022
Day one of #CIPPS22 has started with a wonderful welcome to country from Uncle Allen Madden, Gadigal elder Always was, always will be.
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FairlieLab retweeted
CIPPS@ARC_CIPPS28 Nov 2022
All set for our first annual conference #CIPPS22 in Sydney 🎉🎉 We are looking forward to a great program of talks and networking! 🗣🎙
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New Fairlie group paper: Helical structure in cyclic peptides: effect of N-methyl amides versus esters pubmed.ncbi.nlm.nih.gov/3627…

Helical structure in cyclic peptides: effect of N-methyl amides versus esters - PubMed

An alpha helical turn can be reproduced in a cyclic pentapeptide if the first and fifth amino acid sidechains are correctly joined. Here structural studies (CD, NMR, in silico) reveal why N-methyla...

pubmed.ncbi.nlm.nih.gov
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FairlieLab retweeted
Shiao Chow@SYC_Chm3 Oct 2022
Very happy to share that I have joined @StrathChem as a Chancellor's Fellow at @UniStrathclyde! Immensely thankful for the support from my mentors: @FairlieGroup, Odell Group @uppsalauni, @Adam_S_Nelson, @BOOMchemistry and @patton_lab!
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Landscaping macrocyclic peptides: stapling hDM2-binding peptides for helicity, protein affinity, proteolytic stability and cell uptake dlvr.it/SVLfFD

Landscaping macrocyclic peptides: stapling hDM2-binding peptides for helicity, protein affinity,...

Cyclic peptides that modulate protein-protein interactions can be valuable therapeutic candidates if they can be delivered intact to their target proteins in cells. Here we systematically compare the...

pubmed.ncbi.nlm.nih.gov
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Great to see this paper on stapled peptides out in RSC Chemical Biology. Glad to have played a small part in this work from my time @FairlieGroup. We investigated how crosslinks affect helicity, protein affinity, proteolytic stability and cell uptake. pubs.rsc.org/en/content/arti…

Landscaping macrocyclic peptides: stapling hDM2-binding peptides for helicity, protein affinity,...

Cyclic peptides that modulate protein–protein interactions can be valuable therapeutic candidates if they can be delivered intact to their target proteins

pubs.rsc.org
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Professor David Fairlie was again listed as a highly cited researcher on the Web of Science. Full list: recognition.webofscience.com…
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Prof. David Fairlie awarded NHMRC Investigator Grant for discovering drugs that target key protein-protein interactions in cancer, metabolic and inflammatory diseases.
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Pleased to share our new paper - a review on our synthesis and development of ligands that modulate #MR1 and #MAIT cells in Accounts of Chemical Research @ACSPublications @FairlieGroup @IMBatUQ @CellsMait #ozchem pubs.acs.org/doi/10.1021/acs…

Chemical Modulators of Mucosal Associated Invariant T Cells

Conspectus. Over the past decade, we have contributed to the chemistry of microbial natural products and synthetic ligands, related to riboflavin and uraci

pubs.acs.org
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New Fairlie Group paper makes the cover of ChemBiochem. Late-Stage Hydrocarbon Conjugation and Cyclisation in Synthetic Peptides and Proteins (ChemBioChem 10/2021) Dr. Aline D. de Araujo, Huy T. Nguyen, Prof. David P. Fairlie First published: 19 May 2021 doi.org/10.1002/cbic.2021001…
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Our new #MR1 study with H McWilliam & J Villadangos, via new tools and techniques incl. a stable fluorescent ligand, conformation specific Ab, and genome-wide CRISPR screen #MAIT #ozchem @FairlieGroup @IMBatUQ @ImagingCoE @TheDohertyInst @Bio21Institute pnas.org/content/early/2020/…

Endoplasmic reticulum chaperones stabilize ligand-receptive MR1 molecules for efficient presentat...

The antigen-presenting molecule MR1 (MHC class I-related protein 1) presents metabolite antigens derived from microbial vitamin B2 synthesis to act...

pnas.org
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New research from @FairlieGroup shows the potential of a new inhibitor combination in the fight against #cancer. #IMB #2020IMB Discover more: bit.ly/2ZKZMDl

Achiral Derivatives of Hydroxamate AR-42 Potently Inhibit Class I HDAC Enzymes and Cancer Cell...

Abstract. AR-42 is an orally active inhibitor of histone deacetylases (HDACs) in clinical trials for multiple myeloma, leukemia, and lymphoma. It has few h

pubs.acs.org
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New research from @FairlieGroup shows the potential of a new inhibitor combination in the fight against #cancer. #IMB #2020IMB Discover more: bit.ly/2ZKZMDl

Achiral Derivatives of Hydroxamate AR-42 Potently Inhibit Class I HDAC Enzymes and Cancer Cell...

Abstract. AR-42 is an orally active inhibitor of histone deacetylases (HDACs) in clinical trials for multiple myeloma, leukemia, and lymphoma. It has few h

pubs.acs.org
ACS Publications Bio & Med Chem Content@ACSBioMed27 May 2020
Hydrophobic H-bond shield and quaternary carbon feature in potent achiral HDAC1 inhibitors with anticancer activity: pubs.acs.org/doi/10.1021/acs…
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Congratulations Huy!
Huy Thien Nguyen@HuyThienNguyen30 Jan 2020
Honored to receive the prestigious H. C. Ørsted Medal for exceptional academic performance during my time at @uni_copenhagen, capped off with top marks for my MSc thesis in the @FairlieGroup @IMBatUQ with @ChristianAOlsen as my formal supervisor. #graduated #UniversityMedal
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