PI @MRC_LMB in Cambridge. Immunologist x cell biologist x microbiologist. Occasionally birdwatching. Generally less nerdy than my bio sounds. Views my own.
Cambridge, England
Joined June 2013
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Felix Randow retweeted
A first-of-its-kind meeting! CCMB hosted a unique India-EMBO conference bringing together innate immunity, cell death & autophagy under the unifying theme of cell-autonomous defense. A landmark moment for the field and for India’s research community @EMBO @ccmb_csir @CSIR_IND
Felix Randow retweeted
We celebrated Mizushima Lab's 20th anniversary with a fantastic BBQ! Alumni reunited to share memories. Inspiring to see alumni—nurtured by Dr. Mizushima—thriving in diverse fields. The day was full of laughter and joy. Here's to Mizushima Lab's continued success!
RNF213 ubiquitylates LPS but also restricts LPS-free pathogens: bacteria, parasites and viruses! Is RNF213 an amazingly versatile pattern-recognition receptor (#PRR) or does it act downstream of specific PRRs? The answer hot from the @emboreports press:
embopress.org/doi/full/10.10…
We reveal features in RNF213 consistent with PRR function - a history of strong positive selection and a novel carbohydrate bdg domain, which we solved by #cryoEM. Great collaboration with @HarmitMalik lab Congratulations to all authors, especially Ana, Prathyush and Katerina!
Amazingly, the RNF213 attack on pathogens is not diffusion-controlled. Coats form through rate-limiting initiation events and subsequent cooperative incorporation of further RNF213 monomers. Brilliant collab with J.Boulanger! Thx to @MRC_LMB light & electron microscopy facilities
Felix Randow retweeted
I am happy to share this preprint from my postdoc! By constructing ‘synthetic mitochondria’ in cells, we looked at how real mitochondria decide between going forwards and backwards on microtubules. ⬅️🔋➡️?
A molecular switch for stress-induced activation of retrograde mitochondrial transport biorxiv.org/cgi/content/shor… #biorxiv_molbio
Exciting opportunity for people excited about ubiquitin and cancer biology. Highly recommended!
We are hiring! Two structural biology/biochemistry postdoc positions are available in our lab - come and join a lively Team in the thriving city of Oxford! Deadline 4th October 2024. Further details are here: my.corehr.com/pls/uoxrecruit…
Felix Randow retweeted
We are excited to share new mechanistic insights into DNA replication fidelity! How does human DNA Polymerase Epsilon recognise and proofread errors made during synthesis? 🧬
Read @NatureSMB nature.com/articles/s41594-0…
Felix Randow retweeted
"We describe an orthogonal DNA replication system in E. coli based on the ... replisome of bacteriophage T7.
high transformation efficiencies and seamless integration into standard molecular biology workflows."
Wonderful work from Peter Schultz and co!
An Orthogonal T7 Replisome for Continuous Hypermutation and Accelerated Evolution in E. coli biorxiv.org/cgi/content/shor… #biorxiv_synbio
Felix Randow retweeted
After a long time in the making, our study on bacterial clippases is finally available as a preprint biorxiv.org/content/10.1101/…
These are really fascinating enzymes, for which there will be a ton of applications in studying the #ubiquitin system
Felix Randow retweeted
Two postdoctoral positions available in my group to investigate centromere structure, function and evolution - please get in touch if you are interested!
jobs.cam.ac.uk/job/47525/
jobs.cam.ac.uk/job/47569/
Felix Randow retweeted
Rare opportunity to join my team, as the @PLOSBiology in-house editorial team is growing!
It's a great team in a great journal, if I say so myself 😆
Please reach out if your have Qs & apply if interested!!
UK or US; assoc or senior
Please RT
us241.dayforcehcm.com/Candid…
Felix Randow retweeted
Another fantastic work from the McKenzie Lab! Congratulations to @aydanszeto and Paula Clark.
science.org/doi/10.1126/scie…
Felix Randow retweeted
It was an incredible honor to meet, present and discuss our science with the Emperor of Japan at the Francis Crick Institute @JAPANinUK @TheCrick @imperialcollege 🤩🇯🇵
Felix Randow retweeted
Feeling elated today and so proud I will break my shirt! Congrats @CastelloSanjuan and @EBardossy for your prizes at the #PasteurInnov day!! You are rock stars ⭐️@SalehLabParis @institutpasteur #innovation #LoveScience #PILife #ProudPI
Felix Randow retweeted
UPCOMING EVENT from @BSICambridge & @Cambridgeimmuno
#BSICambridge24 will welcome speakers Prof @MartinGuilliams, Prof @ClareBryant13, Dr @FelixRandow & many more to discuss current & future directions in #immunology 🌠
Submit your abstract 👉bit.ly/45fcslP
Felix Randow retweeted
🏅Congratulations to Charlotte Langner @UCBerkeley for winning the @FEBS_Letters #PosterPrize at #EESImmunity in Heidelberg! 👏🦠
@russellevance @EMBLEvents
#Shigellaeffectors #inflammatorypathways #mousemodel
Felix Randow retweeted
A favorite meeting #EESImmunity, thanks for having me, I'll surely come back next time! Great feedback on our work on Mtb cell death and new ideas and collaborations for future exciting work.
