investigating myeloid malignancy and immune function @VUMChealth PI: Brent Ferrell, MD
Nashville, TN
Joined August 2018
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- Following577
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Ferrell Lab retweeted
CHIP variants are often discovered incidentally in liquid biopsy testing, but is plasma cell-free DNA reliable when CHIP variants are the desired finding? 🩸@BloodAdvances @AlexBickMDPhD 🧵1/12
Ferrell Lab retweeted
Please check out our recent pub -> proud of Paran’s (Bubba) hard work showing that AML drives neutrophil immaturity thru inflammatory NFκB signaling. A team-science effort uncovering how AML reshapes healthy cell maturation. ashpublications.org/blood/ar…
Ferrell Lab retweeted
This work led by Dr. Ferrell leverages single-cell transcriptomics to characterize cell states across the hematopoietic stem and progenitor-myeloid differentiation landscape in lower-risk #MyelodysplasticSyndromes.
🔎 Take a closer look: bit.ly/42PVs5p
Ferrell Lab retweeted
Stay up-to-date and explore the latest findings in the April Issue of #ExpHem from @FerrellLabVUMC, Dominique Bonnet, Daniel Lacorazza, and more ➡️ exphem.org/current
Ferrell Lab retweeted
For the first time since January, notification of a new NIH study section meeting has been posted on the Federal Register. It seems to cover multiple review panels, including one for the DP2/New Innovator grant.
Ferrell Lab retweeted
Our latest review, spearheaded by @AmandaDoranLab, on the Bone Marrow Niche in Cardiometabolic Disease is out in @CircRes
@AHA_Research @IUSMDeptMed @VUMCResearch @HHP_UH @CVimmunology @HeatherCaslin @brettheimlich @JonathanBrownMD @FerrellLabVUMC
ahajournals.org/doi/10.1161/…
Ferrell Lab retweeted
Congratulations to @brettheimlich who received the @VUMC_heart Rhodes Scholarship Award for his research this morning! Very proud of all he has accomplished in the lab the past three years @VUMC_Medicine @VUMC_MedPSTP @VUMCgenetics
Ferrell Lab retweeted
Excited to share this paper in @BloodAdvances led by @brettheimlich, @PBdoingscience & @alyssa_c_parker with @FerrellLabVUMC that uses mitochondrial lineage tracing techniques pioneered by @vangalenlab @CalebLareau, @bloodgenes to identify transcriptional consequences of #CHIP
Ever wondered how the two most common CHIP mutations affect gene expression in human PBMCs? Our recently published paper addresses this question using mitochondrial DNA lineage tracing. doi.org/10.1182/bloodadvance…
Ferrell Lab retweeted
🙌Happy to share the first publication of 2024 from #BickLab, exploring the role of CHIP mutation zygosity in predicting clonal hematopoiesis transformation risk to hematologic malignancies published now in @BloodCancerJnl
@AlexBickMDPhD
nature.com/articles/s41408-0…
Ferrell Lab retweeted
Matt Jenkins from @FerrellLabVUMC with the most popular poster describing his work on TET2 and monocyte inflammation in CH. #ASH23
Ferrell Lab retweeted
We are excited to share our work published today in @NatImmunol by @MRudloffMSTP, the whole @PhilipLabVandy team @VUMCDiscoveries, and in collaboration with our fantastic computational biology collaborators @dbetel and his group @WeillCornell. 1/7
nature.com/articles/s41590-0…
Ferrell Lab retweeted
Outstanding science and collaborators at our @TheMarkFdn retreat!
Look for our science coming soon! @FerrellLabVUMC @StanleyCLee @ruilulab
Ferrell Lab retweeted
So proud of these three! It has been phenomenal to see each of them develop into true leaders in biomedical research. Well done, and congratulations!
The Dean’s Award for Research honors outstanding physician scientists. Congratulations! @BReinfeld @MargaretAxelrod @madden_mz
ALT Three students pose with two deans
Ferrell Lab retweeted
One of the biggest surprises in studies of clonal hematopoiesis has been how few mutations are in classical oncogenes and tumor suppressors. Instead, the majority of mutations are in "epigenetic" factors. Why? This is a mystery that has perplexed me for >10 years.
Ferrell Lab retweeted
Ever wondered where to find patients for a CHIP/cardiovascular disease clinical trial? How about in the cardiac cath lab. 🧵medrxiv.org/content/10.1101/…
Ferrell Lab retweeted
HUGE CONGRATS to @jordanberlin5 for his OFFICIAL title as Director, Division of Hematology/Oncology @VUMC_Cancer !!! Well deserved!!! 🙏👏 @benhopark @KimrynRathmell @VUMCHemOnc @VUMChealth @VUMC_MD #cancer @eaonc @drlauragoff @VUMC_Insights
Ferrell Lab retweeted
Reliably identifying #CHIP mutations that predispose to blood cancer & aging diseases is hard. In @BloodJournal today, @DrFlashHeart shares our secret sauce: leveraging large scale data.
cc: @VUMCgenetics @VUMC_Medicine @VUMC_Cancer @AllofUsResearch
🧵👇
Our paper demonstrating an approach to CHIP curation in large datasets is now out in Blood (@BloodJournal)! 🩸
We identify CHIP in >500,000 individuals and show how common challenges such as sequencing artifacts and germline variants can be addressed.
ashpublications.org/blood/ar…
Ferrell Lab retweeted
Happy to share our article on lymphoid clonal hematopoiesis (L-CH) in @BloodCancerJnl led by incredible @VUmedicine student Kelly von Beck! We dissect the potential implications of L-CH for malignancy, immunity & treatment.
@AlexBickMDPhD @FerrellLabVUMC
nature.com/articles/s41408-0…
Ferrell Lab retweeted
In new preprint, we show how a small number of mutated #CHIP cells can cause CVD through driver gene specific mechanisms.
The secret sauce: identifying which cells have #CHIP mutation by combining mitochondrial lineage tracing with single cell DNA sequencing🧵👇
Hey #CHIP folks, ever wondered how clonal cells in the periphery differ from their wildtype counterparts? check out👉biorxiv.org/content/10.1101/… @AlexBickMDPhD @FerrellLabVUMC @alyssa_c_parker @PBdoingscience
Ferrell Lab retweeted
First major project of graduate school is well on its way! Hearty thanks to all those who mentored me along the way @FerrellLabVUMC @AlexBickMDPhD @alyssa_c_parker
Hey #CHIP folks, ever wondered how clonal cells in the periphery differ from their wildtype counterparts? check out👉biorxiv.org/content/10.1101/… @AlexBickMDPhD @FerrellLabVUMC @alyssa_c_parker @PBdoingscience