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Filiano Lab

@FilianoLab

We study neuroinflammation, autoimmunity, and rare diseases.

 PSU ➡️ UAB ➡️ UVA ➡️ Duke
FilianoLab.org
Joined April 2017
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Photo by Filiano Lab (@FilianoLab)Photo by Filiano Lab (@FilianoLab)Photo by Filiano Lab (@FilianoLab)Photo by Filiano Lab (@FilianoLab)Photo by Filiano Lab (@FilianoLab)Photo by Filiano Lab (@FilianoLab)Photo by Filiano Lab (@FilianoLab)Photo by Filiano Lab (@FilianoLab)Photo by Filiano Lab (@FilianoLab)Photo by Filiano Lab (@FilianoLab)
Happy to drop this in the New Year. Learn how the “tough momma” regulates her house. @JExpMed @Dukeneurosurg rupress.org/jem/article-abst…
Mural cells interact with macrophages in the dura mater to regulate CNS immune surveillance

Mural cells interact with macrophages in the dura mater to regulate CNS immune surveillance

Min et al. show mural cells physically contact macrophages in the dura to regulate trafficking of CNS antigen-specific T cells. Mural cells are altered in

rupress.org
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Was a blast guest editing this special issue for @J_Immunol . Check out these amazing reviews on brain border sites. academic.oup.com/jimmunol/ar…
Neuroimmune communication at the borders of the brain

Neuroimmune communication at the borders of the brain

The concept of a central nervous system (CNS) border originates from the late 19th century work of Paul Ehrlich and Edwin Goldman showing that water-solubl

academic.oup.com
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Study in Mice Links Immune System to ADHD, Neurobehavioral Conditions corporate.dukehealth.org//ne…
Study in Mice Links Immune System to ADHD, Neurobehavioral Conditions

Study in Mice Links Immune System to ADHD, Neurobehavioral Conditions

DURHAM, N.C. – Building on research that has linked immune responses with certain neurobehavioral conditions, researchers at Duke Health have identified how a key infection-fighting function is...

corporate.dukehealth.org
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Today I was discussing the evolutionary differences in the mouse and human brains. Please feel free to use this in your lectures. Really, you don’t even need to give me credit.
Image from Filiano Lab (@FilianoLab)
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Excited to share our labs latest work looking at how Prolonged STAT1 signaling in neurons causes hyperactive behavior. We think this could have implications for ADHD and other neurological conditions affecting the basal ganglia. @immunodani sciencedirect.com/science/ar…
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This was the final chapter to Dr. Clark’s thesis and can’t wait to see how much see accomplishes in her career.
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Grateful for this suppport from the @Rosenau_Fdn . Hoping this work translates to help those living with #Krabbe.
Rosenau Family Research Foundation (@Rosenau_Fdn) profile pictureRosenau Family Research Foundation@Rosenau_Fdn24 Jun 2024
Anthony Filiano, PhD, assistant professor in the Duke Department of Neurosurgery, has received a $375,000 grant from the Rosenau Family Research Foundation for a 3-year project titled, “Immune Responses in Peripheral Nerves After Hematopoietic Stem Cell Transplants for Krabbe!
Image from Rosenau Family Research Foundation (@Rosenau_Fdn)
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Huge honor to put a hood on The Dr. Clark. Congrats @immunodani!! @ImmunologyDuke
Image from Filiano Lab (@FilianoLab)
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Save the date for #GliaCamp2024. Another fantastic lineup with keynote speakers @PhiPop and @LehtinenLab. Same location at the beautiful Rigmor House in Chapel Hill, NC. Thanks to support from @ImmunologyDuke, @DukeBrain, @DukeCellBiology.
Image from Filiano Lab (@FilianoLab)
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There is a mind blowing high response to placebo in #lupus. This shocked me when I heard this years ago. Found this meta analysis while prepping for class. In 24 randomized controlled trials, placebo response 36.2% for primary end points 🤯.
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doi.org/10.1093/rheumatology…
Response to placebo in non-renal, non-neuropsychiatric systemic lupus erythematosus: a systematic...

Response to placebo in non-renal, non-neuropsychiatric systemic lupus erythematosus: a systematic...

AbstractObjectives. Most randomized controlled trials (RCTs) in SLE have failed to reach their respective end points, with the rates of response to placebo

academic.oup.com
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Beautiful cover from our study in @JExpMed! Image taken by @ShaneONeil718. doi.org/10.1084/jem.20230326
Image from Filiano Lab (@FilianoLab)
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Also check out the commentary by @BrainyNicole and the Daneman lab highlighting our work and other important aspects of the meningeal layers.
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What an amazing study by @LehtinenLab. I’m fascinated by this crazy thing. What is the variability of the Reissner’s fiber in a healthy individual? How does its structure change in disease? Does this impact CSF fluid dynamics? So many questions. Someone in @Dukeneurosurg?
Lehtinen Lab (@LehtinenLab) profile pictureLehtinen Lab@LehtinenLab5 Dec 2023
Heard of Reissner’s fiber? No? You’re not alone! This bizarre brain structure forms during embryogenesis from SCO-spodin protein & extends from subcommissural organ to spinal cord NEW: @Huixin_BJ et al show developmental importance of SCO-spondin in mice shorturl.at/drwIY
Image from Lehtinen Lab (@LehtinenLab)
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Check out the lab’s latest paper. We used multiple assays to show umbilical cord tissue MSCs suppress microglia and the release of TNF. sciencedirect.com/science/ar…
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These assays range from a model of spinal cord demyelination, all the way down to a fast, reliable, and cheap cell culture system that can be validated for a potency assay.
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Happy Thanksgiving. Grateful to share the labs lastest pub: Improving thymus implantation for congenital athymia with interleukin‐7 onlinelibrary.wiley.com/doi/…
Clinical & Translational Immunology | ASI Journal | Wiley Online Library

Clinical & Translational Immunology | ASI Journal | Wiley Online Library

In this study, we found that interleukin-7 greatly improved T cell development and expanded the T cell receptor repertoire after thymus implantation in athymic nude mice. Thymus implantation is a...

onlinelibrary.wiley.com
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Thymus implants are an FDA approved therapy for children born without a thymus. This saves lives but the recipients only develop a small T cell compartment; the therapy definitely can be improved.
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After a few years off, the Filiano Lab is back at @SfNtweets. Come visit. @immunodani @ShaneONeil718
Image from Filiano Lab (@FilianoLab)
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Introducing Dr. Clark!!! @immunodani survived a new PI, a fatal explosion (seriously!), and a global pandemic. So proud 🥹 @ImmunologyDuke
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Happy to share our latest work exploring the weird ways neurons respond to IFN-gamma! @immunodani @ShaneONeil718 Prolonged STAT1 activation in neurons drives a pathological transcript... sciencedirect.com/science/ar…
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Had a great time representing MC3 yesterday with @DukeBioCoRE. Thanks for the opportunity! @immunodani
Image from Filiano Lab (@FilianoLab)
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One of my favorite days of the year! #GliaCamp2023 was 🔥. Amazing talks by trainees and our keynote speakers @JenGommerman and @ArlottaLab.
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Beautiful artwork by @DurhamSciComm
Image from Filiano Lab (@FilianoLab)
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Whelp Quartzy, it was a good run.
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Not to brag, but I’ve been conducting disruptive science since grad school, when I broke a centrifuge in my first rotation in the @TUnnasch lab. nature.com/articles/d41586-0…
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