Instructor in @GiulioDraetta lab @MDAndersonNews | DNA replication, genome instability, cancer
Houston, TX
Joined May 2019
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Remarkable discovery on the role of cell plasticity in shaping genome evolution. Congratulations to @LabGenovese, @perelli_luigi and @Li_Zhang_LZ
Delighted to share our new work on EMT in cancer evolution! A special thanks the fantastic mentorship of @LabGenovese and the wonderful collaborators! We found that specific genomic patterns amplify and segregate only in selected phenotypes. nature.com/articles/s41586-0…
Francesca Citron retweeted
Our article "MCM double hexamer loading visualized with human proteins" published in Nature today! ❄️🔬🧬🎉🥳
Great collaboration with John Diffley's lab. Congratulations to Florian Weissmann, Julia Greiwe and all other authors! rdcu.be/d1F7m
Francesca Citron retweeted
Long-term breast cancer response to CDK4/6 inhibition defined by TP53-mediated geroconversion dlvr.it/TG7x8j
Francesca Citron retweeted
Amino acid is a major carbon source for hepatic lipogenesis dlvr.it/TG3kH4
Francesca Citron retweeted
GLP-1 receptor agonists, which are effective for weight loss, can cause substantial muscle loss.
A Comment in @TheLancetEndo discusses the effects of GLP-1 receptor agonists on skeletal muscle mass: hubs.li/Q02WgC490
ALT Figure showing selected key roles of skeletal muscle as a structural versus metabolic organ. Copyright: Elsevier Ltd. All rights are reserved.
Francesca Citron retweeted
Delighted to share our skin transposons paper now online @CellCellPress !#TransposableElements #mobileDNA #Regeneration #Skin #StemCell
cell.com/cell/fulltext/S0092…
Congrats to outstanding postdoc Ying Lyu and our amazing team YounJoo, Ericka, Richa, @MDA_UTHGrad #proudPI! A big shout out to our incredible collaborators @kchenken , Yue Lu, Taiping Chen, and others @MDAndersonNews .
In our murine model, we saw viral like particles originated from the endogenous retroviruses, accompanied by hair loss and stem cell exhaustion, which can be rescued by antiviral drugs. Very excited about the implications behind these findings, especially how innate antiviral pathways can be leveraged to expose cancer vulnerability #EndCancer. Look forward to the next discoveries!
Full article here: authors.elsevier.com/a/1k0GS…
Francesca Citron retweeted
So happy to report a new discovery relating obesity to the selective pressure for driver mutations, out now in @NatureGenet nature.com/articles/s41588-0…. This is the latest science from all-star Cerise Tang w/help from soon-to-be all-star Venise Jan Castillon, and co-led by Justin Jee
Francesca Citron retweeted
Mitochondrial fatty acid oxidation drives senescence
science.org/doi/10.1126/scia…
Thank you @Aiims1742
New preprint from the @MDAndersonNews #PancreaticCancer team of famous Italians 🇮🇹 (@DraettaG @LabGenovese @DiPilatoMauro @FrancescaCitron & Andrea Viale):
WRAD core perturbation impairs DNA replication fidelity promoting immunoediting in #PancreaticCancer
biorxiv.org/content/10.1101/…
Even cancer cells require a certain threshold of genetic stability, crossing which can render them vulnerable to elimination. This study identifies a potential biomarker of genomic stability in pancreatic cancers (DPY30), loss of which leads to chromosomal instability & T cell mediated clearance of cells with complex karyotypes.
1/3. Our preprint is out! 🧬 Kudos to all the fantastic collaborators for their remarkable contributions. Special thanks to
@DraettaG, Andrea Viale, @LabGenovese and @DiPilatoMauro
biorxiv.org/content/10.1101/…
2/3. We identified a non canonical function of the WRAD core in sustaining genomic stability by buffering excessive #DNAreplication in #PancreaticCancer.
Francesca Citron retweeted
Thrilled to share our new work @biorxivpreprint:
biorxiv.org/content/10.1101/…
Our Repli-Histo labeling marks nucleosomes in euchromatin and heterochromatin in live cells. We reveal genome chromatin is essentially replicated from regions with greater nucleosome motions. 1/2
Francesca Citron retweeted
How To Choose a Good Scientific Problem (1/3)
@MolecularCell #PhD #PhDlife #academics #AcademicChatter #AcademicTwitter #Postdocs #Research #Science
Francesca Citron retweeted
Our table at the Roundtable Session on Building Connections
@AACR Grantee Summit
Thank you @AACR and @AstraZeneca for supporting my research and for the opportunity to share it. Terrific first AACR Grantee Summit!
Dr. Francesca Citron from @MDAndersonNews speaks about WRAD complex, its interaction with the replisome, its impact on epigenetic regulation and immunoediting in PDAC.
aacrjournals.org/cancerres/a…
@FrancescaCitron @sastewartlab @DrMhidalgo @AACR
Francesca Citron retweeted
Need answers to complex biology questions? BioloGPT provides novel hypotheses and insights from a database of 122,038+ full papers, updated daily.
Check it out: biologpt.com
Francesca Citron retweeted
1/7 Our latest preprint is out! 🚨 @Sour_Agrawal , @xiuhua_linwisc , @viveksusvirkar et al. discover human RPA is a critical telomerase processivity factor essential for telomere maintenance. This reshapes our understanding of human telomerase regulation. biorxiv.org/content/10.1101/…
Thank you, Aria! Great science at the #cshlcancer24, looking forward to the next!
Francesca Citron retweeted
Train PhD students to be thinkers not just specialists
#PhD #PhDlife #academics #AcademicChatter #AcademicTwitter #Postdocs #Research #Science
