Cell biologist, Ph.D. Interested in all types of #Autophagy and intracellular traffcking. CNRS UMR 144, Institut Curie, Paris, France.
Paris, France
Joined July 2012
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I’m thrilled to share that my first paper as a postdoc is out in @J_Cell_Sci! 🎉
We discovered that upon starvation, the vimentin network rapidly compacts to organize endosome-ER membrane contact sites to promote autophagosome biogenesis!
doi.org/10.1242/jcs.264635
Quentin Frenger retweeted
Our study on DFCP1 and lysosome membrane repair is live! We uncover a previously unrecognized role for omegasomes in the cellular response to lysosomal membrane damage, revealing another layer of regulation in how damaged lysosomes are repaired.
nature.com/articles/s41556-0…
Quentin Frenger retweeted
.@FrengerQuentin, Etienne Morel & team find that vimentin intermediate filaments reorganise to mobilise ER–endosome contact sites, establishing a crucial spatial platform for starvation-induced autophagy initiation.
Highlight : journals.biologists.com/jcs/…
journals.biologists.com/jcs/…
ALT Figure showing that LC3B and DFCP1 are found in proximity to ER and vimentin overlapping regions.
Quentin Frenger retweeted
Congratulations to @FrengerQuentin, one of our Biomed News curators. Quentin curates the weekly report on non-canonical #autophagy. You can subscribe to his report here biomed.news/bims-nocaut
First person – Quentin Frenger journals.biologists.com/jcs/…
Big thank you to @MEMBRAMICS_lab @Carla_Alemany1 @DelevoyC and everyone that made this possible! #Autophagy
Quentin Frenger retweeted
Mechanical forces stimulate Golgi export | bioRxiv biorxiv.org/content/10.1101/…
Quentin Frenger retweeted
Excited to share our new paper: 'LASER couples damage sensing to ESCRT assembly for lysosome repair.' Congrats to dream team @clairegoul and @aakritijain24 for uncovering a new lysosome repair pathway and its connection to neurodegeneration. bit.ly/49FCPoq
Quentin Frenger retweeted
Hello world, meet 1,000× Expansion Microscopy.
1,000,000,000× expansion by volume! A gel that starts at a few centimeters will then expand to the volume of an Olympic swimming pool. biorxiv.org/content/10.64898…
In our new bioRxiv preprint, work carried out between MIT and UMG, led by Helena Hu in collaboration with scientists from the labs of @eboyden3 Ed Boyden, Silvio Rizzoli, and myself, we present Thousandfold Expansion Microscopy.
By enlarging biological specimens across multiple rounds of expansion, molecular-scale features, as small as the distances between adjacent amino acids, can be visualized with conventional optical microscopes.
Democratizing super-resolution microscopy.
Quentin Frenger retweeted
Excited to share our new study in @NatureComms!
We uncover a key role for noncanonical autophagy (CASM) in neural tube formation through mb remodeling and endocytic recycling.
Using human neural tube organoids, we reveal mechanisms that may be relevant to neural defects. 🧠🧬
Quentin Frenger retweeted
Anthropic tests Claude Operon for scientific research in biology
Operon is a new Claude desktop app mode designed for biology and health research, featuring dedicated project tools and session management.
testingcatalog.com/anthropic…
Quentin Frenger retweeted
NimbusImage: a cloud computing platform for image analysis.
nature.com/articles/s41592-0…
Quentin Frenger retweeted
Vimentin intermediate filaments support autophagosome biogenesis at ER-endosomes contact sites in response to starvation biorxiv.org/content/10.64898…
Quentin Frenger retweeted
Vimentin intermediate filaments support autophagosome biogenesis at ER-endosomes contact sites in response to starvation biorxiv.org/content/10.64898… #biorxiv_cellbio
My first postdoc preprint is out!
Upon starvation, the Vimentin IFs network rapidly compacts (in <15 min!) to "cage" ER-Endosome membrane contact sites. This spatial confinement is crucial for autophagosome biogenesis.
biorxiv.org/content/10.64898…
Quentin Frenger retweeted
LRRK2 integrates Rab and GABARAP interactions to sense and respond to distinct lysosomal stresses | bioRxiv biorxiv.org/content/10.1101/…
Quentin Frenger retweeted
As the saying goes, one man’s trash is another man’s treasure: the flow-cytometry doublets that are routinely excluded from analysis are in fact a rich source of tumor-reactive T cells.
#immunology
#science
#tumor
#immunotherapy
nature.com/articles/s41586-0…
What a beautiful time at the European Intermediate Filament Meeting 2025 in Lyon! I was so glad to meet such a welcoming community.
I'm honored to have won the Best Oral Communication Prize for my recent postdoc project on Vimentin and Autophagy!
Huge thanks to the organizers!
Quentin Frenger retweeted
ATG16L1 controls mammalian vacuolar proton ATPase rupress.org/jcb/article-abst…
Quentin Frenger retweeted
Lysosomal vacuolation has been observed for decades in many diseases.
Today in @ScienceMagazine, we report LYVAC/PDZD8-mediated directional, ER-to-lysosome lipid transfer as an essential mechanism for lysosomal vacuolation.
science.org/doi/10.1126/scie…
