We study chromatin conformation regulating transcriptional dynamics in mature cells
IFC-UNAM, Mexico City
Joined January 2019
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Furlan-Magaril_lab retweeted
Today, I can finally share some incredibly exciting news.
Our work, "TIF1γ regulates stability of regulatory T cells during inflammation," has been published in Nature Immunology.
nature.com/articles/s41590-0…
Furlan-Magaril_lab retweeted
We just finished writing up this beautiful story on how transcription factors can generate pulses by using chromatin (led by Cece & @ECosta173 ): Bifunctional transcriptional effector domains control gene expression pulses in an occupancy-dependent manner biorxiv.org/content/10.64898…
Furlan-Magaril_lab retweeted
Liveposting on Bluesky: Lingbin Ni: Haplotype-resolved chromatin differences and genome structural variation #ASHG25 bsky.app/profile/michaelhoff…
Furlan-Magaril_lab retweeted
There is a lot of truth to this. The advances in sequencing throughput continue. The one exception might be 3D genomics. 100x coverage of the human 3D genome at nucleosome resolution would require 10^16-17 reads: nature.com/articles/s41588-0…
Furlan-Magaril_lab retweeted
Estimados colegas y miembros de la Sociedad Mexicana de Inmunología, les compartimos la propuesta de candidatura que el Dr José Luis Maravillas JL Maravillas Montero y yo estamos sometiendo para ocupar los puestos de vicepresidente y prosecretario de la SMI, voten por nosotros
Furlan-Magaril_lab retweeted
Our new preprint is out!
We combined single-nucleosome imaging and 3D-SIM to reveal:
🔹 Euchromatin forms condensed domains, not open fibers
🔹Cohesin loss increases nucleosome mobility without decompaction
🔹Cohesin prevents neighboring domain mixing
Full story & movies👇
Is euchromatin really “open”? 🧬Our new study @bioRxiv suggests otherwise. Using super-resolution imaging🔬 @shiori_iida @MasaAShimazoe reveals: Euchromatin forms condensed domains in live cells. Cohesin constrains them and prevents domain mixing. 🔗biorxiv.org/cgi/content/shor… (1/3)
Furlan-Magaril_lab retweeted
Think babies are born without a body clock? ⏰
Not true! By the time they’re born, infants already have a working circadian system that responds to light. Here’s the timeline of how their internal clock develops before birth 👇@LauraKervezee
frontiersin.org/journals/neu…
Furlan-Magaril_lab retweeted
Age-dependent effect of environmental enrichment on the neural 3D chromatin interactome dlvr.it/TMgcnJ
Furlan-Magaril_lab retweeted
🚨New preprint from the lab🚨
🧬 What keeps certain chromatin domains anchored at the nuclear periphery? Our new genome-wide HiDRO screen uncovers a key role for RNA-binding protein hnRNPK.
biorxiv.org/content/10.1101/…
Furlan-Magaril_lab retweeted
WORK!
My lab currently have 5 (!) open positions for postdocs/PhD students for:
-Nanopore protein sequencing
-Archaeal CDV cell division
-Microfluidics for synthetic cells
-Nuclear Pore Complex
-Origami mimics of peroxisomes
Please apply! ceesdekkerlab.nl/come-join-u…
RT=👍
Furlan-Magaril_lab retweeted
SCIENCE IN MEXICO: A RISING FORCE AMID ADVERSITY. I came back knowing the funding would be scarce, the bureaucracy maddening, and the equipment overpriced. But also knowing I’d find freedom, brilliant students, and generous colleagues. I have no regrets shorturl.at/Mqd1N
Furlan-Magaril_lab retweeted
It's out! Our Science & Society article in @TrendsCellBio , in collaboration with @rocamboleando
Unlocking Latin America´s scientific potential: challenges and opportunities in a globalized world 🌎 cell.com/trends/cell-biology…
Furlan-Magaril_lab retweeted
In a Science study last year in mice, researchers introduced CHARM, a compact and versatile epigenetic editor that can be used to silence prion protein throughout the brain.
Learn more in this #SciencePerspective: scim.ag/3IBm0jz
ALT A graphic showing epigenetic editing in neurodegeneration
Furlan-Magaril_lab retweeted
⚠️ CTCF binding landscape is shaped by the epigenetic state of the N-terminal nucleosome in relation to CTCF motif orientation
Published July 4th 2025 (today)
academic.oup.com/nar/article…
Furlan-Magaril_lab retweeted
Our preprint describing the Range Extender element, which is required and sufficient for long-range enhancer activation at the Shh locus, is out in @Nature. nature.com/articles/s41586-0…
How do enhancers work over distances that sometimes exceed megabases? Excited to share our work led by @gracecbower where we uncover a unique sequence signature globally associated with long-range enhancer-promoter interactions in developing limb buds: biorxiv.org/content/10.1101/… 1/
Furlan-Magaril_lab retweeted
Here's a new, very exciting paper from our #CDlab:
cell.com/cell-reports/fullte…
Here, Brian Analikwu, Alice Deshayes et al show that dense linear protein arrays (such as telomeres) stop loop-extruding SMC motors!
Great collaboration with Marcand lab.
see bsky.app/profile/ceesdekker.…
Furlan-Magaril_lab retweeted
New research in Science establishes #CRISPR-associated transposase (CAST) as a powerful platform technology for efficient, RNA-guided gene integration in human cells. scim.ag/3FgKo93
Furlan-Magaril_lab retweeted
Online Now: The nucleolar granular component mediates genome-nucleolus interactions and establishes their repressive chromatin states dlvr.it/TKxzZk
Furlan-Magaril_lab retweeted
Se crea la Unidad de Edición Genética y Criopreservación en el @IFC_UNAM.
Es la primera en su tipo en México y Centroamérica.
gaceta.unam.mx/se-crea-la-un…
Furlan-Magaril_lab retweeted
Today we celebrated the International Day of Immunology and the opening of the Genetic Editing and cryopreservation Unit @IFC_UNAM , a project that has been in development for several years and is now finally coming to fruition. Many thanks to everyone who made this happen❤️
