
Structural basis of peptide-mediated protein communication and function @HebrewU Member of @RosettaCommons. Tweets by lab members. 🦋 https://teapawt.net/t.co/UMEreURWke 🦋
Jerusalem, Israel
Joined August 2020
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Ora Furman Lab 🎗 retweeted
🚨The Bits to Binders Competition has concluded!🧬
One year ago we gathered scientists from around the world to design and submit protein binders that cause immune cells to target and eliminate CD20+ tumors
Spoiler: They work!
Ora Furman Lab 🎗 retweeted
1/13 🧵 Today, Bindcraft was published in @Nature , one of the most famous AIs in biology for designing protein–protein interactions (PPI). In my opinion. Bindcraft represents one of the most important advances in the post–AlphaFold2 era.
Ora Furman Lab 🎗 retweeted
I am super excited to announce that I will be starting my lab at the Department of Pharmacology of the University of Zurich in Switzerland next year!
Ora Furman Lab 🎗 retweeted
Our paper is out on biorxiv! Very excited to share our results - we find signal peptides might be structurally important for quite a few protein isoforms. Full thread soon!
Signal peptides as potential structural modulators of human splice isoforms biorxiv.org/content/10.1101/… #biorxiv_bioinfo
Ora Furman Lab 🎗 retweeted
If you missed out on Sarel Fleishman's extraordinary talk last night, have no fear - you can check out the recording 👇
youtu.be/2aaWh8yVq8U
Ora Furman Lab 🎗 retweeted
Remember to tune in at 6pm CET May 12 for the next seminar in our series with Prof. Tony Hunter (@salkinstitute) and Dr. Jesús Alvarado-Valverde (@imbmainz).
Register to attend:
tinyurl.com/PMCseminar2
Join us at 6pm CET May 12 for the next seminar in our series with Prof. Tony Hunter (@salkinstitute) and Dr. Jesús Alvardo Valverde (@imbmainz).
Register to attend:
tinyurl.com/PMCseminar2
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Ora Furman Lab 🎗 retweeted
Either if you attended or wanted but could not - please tell us how it works for you!
Thanks to everyone who has attended the PMC seminars!
We have decided to review the timing of the seminar series. If you have any thoughts about the timing of the seminars (currently 6-7pm CET every 2nd Mon of the month), please fill out this form: forms.gle/VZkU2fWkswxYbrZf8
Ora Furman Lab 🎗 retweeted
Remember to join us at 6pm CET April 14 for the next seminar in our series with Prof. Anne-Claude Gingras (@UofT) and Dr. Veronica Venafra.
Register to attend: tinyurl.com/register-pmc-sem…
You can find recordings of previous seminars here: youtube.com/@PMCModularity
Join us at 6pm CET April 14 for the next seminar in our series with Prof. Anne-Claude Gingras (@UofT) and Dr. Veronica Venafra.
Register to attend: tinyurl.com/register-pmc-sem…
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Ora Furman Lab 🎗 retweeted
🚨Paper alert 🚨 Our latest research is out in @Nature! We reveal a surprising new role for the proteasome in innate immunity: generating antimicrobial peptides that can directly disrupt bacterial membranes. 🦠⚡ @WeizmannScience @Sys_Immunology
🔗 nature.com/articles/s41586-0…
🧵👇
Ora Furman Lab 🎗 retweeted
📣 Save the dates 📅
We are organizing a Benzon Symposium on "Protein structure prediction and design" with what I think is an amazing set of speakers
Meeting will take place in Copenhagen 🇩🇰 on Sept. 1–4, 2025, and abstract submission will open in March

ALT Flyer for a Benzon Symposium on Protein structure prediction and design in biology and pharmacology (Sept. 1–4, 2025). Speakers include: Gabriel Rocklin, Birte Höcker, Amy Keating, Tanja Kortemme, Bruno Correia, Sarel Fleishman, Ashutosh Chilkoti, Minkyung Baek, Noelia Ferruz, James Fraser, Alan Moses, Susan Marqusee, Ben Lehner, Mohammed AlQuraishi, Dek Woolfson, Gustav Oberdorfer, Hannah Wayment-Steele, Ora Schueler-Furman, Jenifer Listgarten, Alexander Rives, & Max Bonomi.
Ora Furman Lab 🎗 retweeted
All-atom fixed backbone protein sequence design with FAMPNN
@richardwshuai @talaldotpdb @PossuHuangLab @BrianHie
Ora Furman Lab 🎗 retweeted
Lots of people asking how I would do graduate admissions differently. I don't claim to have a magic bullet, but I can point to some specific things we (US molecular biology PhD programs, although this can probably generalize somewhat) are doing wrong that are easily fixable.
Here's the thing. We have **NO IDEA** how to pick good graduate students. I served on admission committees for 10+ years, and chaired a few, and what I learned is that all the spreadsheets of grades and test scores and recommendations and essays and publications and interview rubrics are just an elaborate ruse to pretend we know what we're doing when we simply don't. Many of the most highly ranked applicants to our "top" program flamed out quickly, and tons of the students we summarily rejected have turned into amazing scientists. But in the name of creating meritocratic seeming rankings that are more about creating a workforce than great scientists (a system that anyone paying attention knows is bullshit), we've created a homogenous process adopted by nearly all institutions that has stamped out the one thing we should be striving for - given our lack of any clear understanding of what leads to success - a wide range of difference talents and experiences.
Ora Furman Lab 🎗 retweeted
🚨🖨️👩🔬New Preprint alert! Please have a look to see how refolding and proteolysis are balanced in malaria parasites🩸🧪🦟So proud in our lab trainees, especially 1st author Amanda Tissawak, for this first major research article from our lab! biorxiv.org/content/10.1101/…
Ora Furman Lab 🎗 retweeted
Remember Golden Gate Claude?
@etowah0 and I have been working on applying the same mechanistic interpretability techniques to protein language models.
We found lots of features and they’re... pretty weird?
🧵
Ora Furman Lab 🎗 retweeted
Much of the success of breakthroughs, such as AlphaFold, is thanks to a database of protein structures dreamed up in the 1960s by Helen Berman go.nature.com/4hp4UCP
Ora Furman Lab 🎗 retweeted
I'm excited to share my first postdoc project: SeqDance, a protein language model that generates embeddings of protein dynamic properties directly from sequence, complementing conventional static structure- and evolution-based methods. Check it out here: biorxiv.org/content/10.1101/…
Ora Furman Lab 🎗 retweeted
It's so great to see protein structure prediction&protein design honored by a Nobel Prize!
Congratulations to David Baker, @demishassabis, &John Jumper. AF2 &Rosetta/RFDiffusion/etc are such great tools. And thanks to Helen Berman & John Moult for the training/testing data!
Ora Furman Lab 🎗 retweeted
Is it time for the protein emoji to return? Can we overcome the past unicode rejection now with the tailwinds of the Nobel Prize?
Can proteins be recognized as important as 🫘 or 🙎or 🥀?
Ora Furman Lab 🎗 retweeted
These laureates are VERY deserving. But an important addendum—no model could be trained without 40 years of Helen Berman and others’ work at the PDB, and we would not be certain of AF’s success without 30 years of John Moult and others’ work on CASP. Hats off to them as well 🥂
BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the 2024 #NobelPrize in Chemistry with one half to David Baker “for computational protein design” and the other half jointly to Demis Hassabis and John M. Jumper “for protein structure prediction.”
Ora Furman Lab 🎗 retweeted
A couple of weeks ago our work on predicting protein-protein interactions in 19 pathogenic bacteria came out in @NatureMicrobiol! Here we screened millions of potential pairs and identified ~1,300 presumed to be novel interactions. nature.com/articles/s41564-0…

































