@GPCRcomplex

Tweeting new papers about #GPCR complexes (dimers and oligomers) from PubMed

Joined November 2019
  • Tweets431
  • Following715
  • Followers1.7K
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Interesting article "Uncoupling serotonin (2C) and dopamine (D2) receptor heterodimers ameliorate PTSD-like behaviors" (via #pubmedontap) ncbi.nlm.nih.gov/pubmed/4012…

Uncoupling serotonin (2C) and dopamine (D2) receptor heterodimers ameliorate PTSD-like behaviors -...

These findings revealed a causative role of D2R/5-HT2CR hetero-dimer in PTSD and could be reversed by TAT-D2R-KL treatment.

pubmed.ncbi.nlm.nih.gov
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Interesting article "GPCR dimerization: Drug discovery aspects and targets in renin-angiotensin systems" (via #pubmedontap) ncbi.nlm.nih.gov/pubmed/4006…
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Interesting article "Molecular basis of β-arrestin coupling to the metabotropic glutamate receptor mGlu3" (via #pubmedontap) ncbi.nlm.nih.gov/pubmed/4005…

Molecular basis of β-arrestin coupling to the metabotropic glutamate receptor mGlu3 - PubMed

β-Arrestins (βarrs) mediate the desensitization and internalization of activated G-protein-coupled receptors (GPCRs). The molecular mechanism by which dimeric family C GPCR members recruit arrestins...

pubmed.ncbi.nlm.nih.gov
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Interesting article "Receptor dimers and biased ligands: Novel strategies for targeting G protein-coupled receptors" (via #pubmedontap) ncbi.nlm.nih.gov/pubmed/4002…

Receptor dimers and biased ligands: Novel strategies for targeting G protein-coupled receptors -...

G protein-coupled receptors (GPCRs) are the largest superfamily of membrane receptors. They regulate physiological and pathological processes such as metabolic homeostasis, cell proliferation and...

pubmed.ncbi.nlm.nih.gov
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Interesting article "Structural and evolutionary insights into the functioning of glycoprotein hormones and their receptors" (via #pubmedontap) ncbi.nlm.nih.gov/pubmed/3987…

Structural and evolutionary insights into the functioning of glycoprotein hormones and their...

The neuroendocrine system that comprises the glycoprotein hormones (GpHs) and their receptors is essential for reproduction and metabolism. Each GpH hormone is an αβ heterodimer of cystine-knot...

pubmed.ncbi.nlm.nih.gov
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Interesting article "Advances in the therapeutic potentials of ligands of the apelin receptor APJ" (via #pubmedontap) ncbi.nlm.nih.gov/pubmed/3987…
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Interesting article "Conformational diversity in class C GPCR positive allosteric modulation" (via #pubmedontap) ncbi.nlm.nih.gov/pubmed/3980…
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Interesting article "Chemically Induced Dimerization via Nanobody Binding Facilitates in Situ Ligand Assembly and On-Demand GPCR Activation" (via #pubmedontap) ncbi.nlm.nih.gov/pubmed/3973…

Chemically Induced Dimerization via Nanobody Binding Facilitates in Situ Ligand Assembly and...

Methods that enable the on-demand synthesis of biologically active molecules offer the potential for a high degree of control over the timing and context of target activation; however, such approac...

pubmed.ncbi.nlm.nih.gov
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Interesting article "Molecular insights into the activation mechanism of GPR156 in maintaining auditory function" (via #pubmedontap) ncbi.nlm.nih.gov/pubmed/3963…
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Interesting article "Sphingosine-1-phosphate activates LRRC8 volume-regulated anion channels through Gβγ signalling" (via #pubmedontap) ncbi.nlm.nih.gov/pubmed/3949…

Sphingosine-1-phosphate activates LRRC8 volume-regulated anion channels through Gβγ signalling -...

Volume-regulated anion channels (VRACs) formed by leucin-rich repeat containing 8 (LRRC8) proteins play a pivotal role in regulatory volume decrease by mediating the release of chloride and organic...

pubmed.ncbi.nlm.nih.gov
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Interesting article "Fusarium graminearum Ste2 and Ste3 receptors undergo peroxidase-induced heterodimerization when expressed heterologously in Saccharomyces cerevisiae" (via #pubmedontap) ncbi.nlm.nih.gov/pubmed/3943…
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Interesting article "Mechanistic exploration of bioactive constituents in Gnetum gnemon for GPCR-related cancer treatment through network pharmacology and molecular docking" (via #pubmedontap) ncbi.nlm.nih.gov/pubmed/3946…

Mechanistic exploration of bioactive constituents in Gnetum gnemon for GPCR-related cancer treatm...

G Protein-Coupled Receptors (GPCRs) are integral membrane proteins that have gained considerable attention as drug targets, particularly in cancer treatment. In this study, we explored the capacity...

pubmed.ncbi.nlm.nih.gov
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Interesting article "Fusarium graminearum Ste2 and Ste3 receptors undergo peroxidase-induced heterodimerization when expressed heterologously in Saccharomyces cerevisiae" (via #pubmedontap) ncbi.nlm.nih.gov/pubmed/3943…
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Interesting article "Cryo-EM structure of human class C orphan GPCR GPR179 involved in visual processing" (via #pubmedontap) ncbi.nlm.nih.gov/pubmed/3933…

Cryo-EM structure of human class C orphan GPCR GPR179 involved in visual processing - PubMed

GPR179, an orphan class C GPCR, is expressed at the dendritic tips of ON-bipolar cells in the retina. It plays a pivotal role in the initial synaptic transmission of visual signals from photorecept...

pubmed.ncbi.nlm.nih.gov
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Interesting article "Early Events in β2AR Dimer Dynamics Mediated by Activation-Related Microswitches" (via #pubmedontap) ncbi.nlm.nih.gov/pubmed/3924…

Early Events in β2AR Dimer Dynamics Mediated by Activation-Related Microswitches - PubMed

G-Protein-Coupled Receptors (GPCRs) make up around 3-4% of the human genome and are the targets of one-third of FDA-approved drugs. GPCRs typically exist as monomers but also aggregate to form...

pubmed.ncbi.nlm.nih.gov
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Interesting article "Ligand-Dependent and G Protein-Dependent Properties for the Sweet Taste Heterodimer, TAS1R2/1R3" (via #pubmedontap) ncbi.nlm.nih.gov/pubmed/3923…

Ligand-Dependent and G Protein-Dependent Properties for the Sweet Taste Heterodimer, TAS1R2/1R3 -...

The heterodimeric sweet taste receptor, TAS1R2/1R3, is a class C G protein-coupled receptor (GPCR) that couples to gustducin (Gt), a G protein (GP) specifically involved in taste processing. This...

pubmed.ncbi.nlm.nih.gov
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Interesting article "Structural basis of Frizzled 4 in recognition of Dishevelled 2 unveils mechanism of WNT signaling activation" (via #pubmedontap) ncbi.nlm.nih.gov/pubmed/3922…

Structural basis of Frizzled 4 in recognition of Dishevelled 2 unveils mechanism of WNT signaling...

WNT signaling is fundamental in development and homeostasis, but how the Frizzled receptors (FZDs) propagate signaling remains enigmatic. Here, we present the cryo-EM structure of FZD4 engaged with...

pubmed.ncbi.nlm.nih.gov
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Interesting article "Delineating the stepwise millisecond allosteric activation mechanism of the class C GPCR dimer mGlu5" (via #pubmedontap) ncbi.nlm.nih.gov/pubmed/3920…

Delineating the stepwise millisecond allosteric activation mechanism of the class C GPCR dimer...

Two-thirds of signaling hormones and one-third of approved drugs exert their effects by binding and modulating the G protein-coupled receptors (GPCRs) activation. While the activation mechanism for...

pubmed.ncbi.nlm.nih.gov
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Interesting article "Homodimerization of CB2 cannabinoid receptor triggered by a bivalent ligand enhances cellular signaling" (via #pubmedontap) ncbi.nlm.nih.gov/pubmed/3917…

Homodimerization of CB2 cannabinoid receptor triggered by a bivalent ligand enhances cellular...

G protein-coupled receptors (GPCRs) exist within a landscape of interconvertible conformational states and in dynamic equilibrium between monomers and higher-order oligomers, both influenced by...

pubmed.ncbi.nlm.nih.gov
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Interesting article "Histamine H3 Receptor Isoforms: Insights from Alternative Splicing to Functional Complexity" (via #pubmedontap) ncbi.nlm.nih.gov/pubmed/3906…

Histamine H3 Receptor Isoforms: Insights from Alternative Splicing to Functional Complexity - PubMed

Alternative splicing significantly enhances the diversity of the G protein-coupled receptor (GPCR) family, including the histamine H3 receptor (H3R). This post-transcriptional modification generates...

pubmed.ncbi.nlm.nih.gov
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