These two mice are the exact same age, the human equivalent of 85. The mouse on the right was given an antibody blocking a single inflammatory protein (IL-11) starting in late middle age. Starting treatment at human-equivalent age 55: - Extended median lifespan by 25% in both males and females - Prevented grey hair, frailty, and muscle wasting - Cut late-life cancer deaths in half Three anti IL-11 antibodies (that might extend human lifespan) are already in human clinical trials right now.

Creatine may help women in perimenopause maintain more consistent sleep when combined with strength training. Women taking creatine for 6 weeks had sleep regularity scores 7.4 percentage points higher than the placebo group, reported fewer days of temperature sensitivity, and had greater brain oxygenation during a cognitive task. The protocol was 20 grams of creatine monohydrate daily for 5 days, followed by about 4.5 grams daily, with resistance training twice a week. These are encouraging early findings, particularly for sleep regularity in a population known to suffer from poor sleep quality! I love seeing more creatine research in women. pubmed.ncbi.nlm.nih.gov/4292…

In honor of POTS Awareness Day, I wanted to share a video that I genuinely wish more people would take the time to watch. It’s one of the best videos I’ve come across explaining what POTS actually is and just how debilitating living with this condition can be.

BREAKING: Scientists have used a powerful new form of CRISPR called prime editing directly inside the human body for the first time. They aim to rewrite faulty DNA responsible for Wilson disease that can cause severe liver and brain damage. A major milestone in gene editing.

Scientists found a way to flush Alzheimer’s plaque out of the brain in minutes. Without any surgery and drugs. Your brain has a waste-clearance network called the glymphatic system. It flushes out toxic proteins and dead cells. But it only really activates during deep, slow-wave sleep. If you don't sleep, the trash piles up. Over time, that buildup leads to cognitive decline and Alzheimer's. Until today. Researchers just published a paper proving they can manually trigger this cleaning cycle. Without you ever going to sleep. They used 40.68 MHz ultrashort waves (USW) beamed non-invasively into the brain. Within 10 minutes, the brain's fluid flow rapidly accelerated. The waves artificially synchronized the neurons into a Delta state, the exact frequency of deep sleep. This forced the brain's water channels to open and start flushing out the system. They tested it on mice with traumatic brain injuries and Alzheimer's pathology. The brain swelling dropped. The toxic proteins were cleared out. Cognitive deficits actually improved. No surgery. No massive chemical interventions. Just a frequency.

NIH researchers have discovered a natural defense mechanism that may help the body prevent plaque from building up inside arteries, opening new possibilities for treating atherosclerotic cardiovascular disease, a leading cause of death in the U.S.

🚨 My new paper on small fiber #neuropathy in NONPAINFUL conditions is published. Neuropathy is traditionally defined by neuropathic (tingling, numbness, burning, shooting) pain, but there are neurologic and non-neurologic conditions where objective findings of small fiber neuropathy are highly prevalent despite the pain being absent or minimal. I outline comprehensive treatment options for small fiber neuropathy with both evidence-based and emerging therapies in the Table. 🧠 clinmedres.org/content/24/3/…