Structure, function, and engineering of protein assemblies @UMich. Microbial Biochemistry | Cryo-EM | SynBio | Encapsulins | Natural Products | Enzyme Filaments
Ann Arbor
Joined February 2020
- Tweets49
- Following514
- Followers248
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Giessen Lab retweeted
Nature has a trick to evolve multimeric proteins via gene duplication.
🧬One copy compensates, the other explores.🧬
Although this has only been a theory so far.
Until now: Directed evolution of multimeric proteins by dual-compensatory gene duplication.
biorxiv.org/content/10.64898…
Giessen Lab retweeted
1/ We’re excited to share our work on HIV-1 trafficking by dynein! Led by the amazing @badieyan in the lab with wonderful collaborations with @EdcampbellLab, @GiessenLab, Aiken Lab, Böcking Lab, and @morgan_desantis. TL;DR HIV-1 hijacks the dynein motor protein for motility 🧵
HIV-1 binds dynein directly to hijack microtubule transport machinery biorxiv.org/cgi/content/shor… #bioRxiv
Giessen Lab retweeted
Come join our faculty @UMich in beautiful Ann Arbor!
Learn more and apply at jobs.sciencecareers.org/job/…
Giessen Lab retweeted
Thanks to @GiessenLab and Prof Schiller @FRIAS_UFreiburg for the external examination
Giessen Lab retweeted
Our study on pore structure and molecular flux into #encapsulin nanocompartments with @GiessenLab is now in shiny typeset format in @ScienceAdvances
science.org/doi/10.1126/scia…
Congrats @nurentasneem, Lachlan, Regi, @taylorszyszka and Eric @MyxXanthus from our lab, and... 🧵
Giessen Lab retweeted
Really happy to have played a part in this fascinating look into encapsulin pore structure and porosity lead by @YuHengLau and @GiessenLab with @MeganLOMara science.org/doi/10.1126/scia…
Giessen Lab retweeted
Sydney synthetic biology team, using our cryo-EM, have shown how to engineer protein nanoreactors that control how molecules move in and out. This is a big step forward in #biomanufacturing for ag, medtech and industrial chemistry. micro.org.au/news/synthetic-… @Eduspokesperson @NSWCSE
Giessen Lab retweeted
Triggered reversible disassembly of an engineered protein nanocage @GiessenLab onlinelibrary.wiley.com/doi/…
Giessen Lab retweeted
Even more nanocompartments out there!! Super exciting! Great work @GiessenLab
Large-scale computational discovery and analysis of virus-derived microbial nanocompartments biorxiv.org/cgi/content/shor… #biorxiv_micrbio
Giessen Lab retweeted
Our structural study on #encapsulin protein cage variants for nanoreactor design is now up on #bioRxiv!
First major work from lab stars @nurentasneem and Lachlan... and also featuring 7 cryo-EM structures from the @GiessenLab🤯(1/5)
Pore structure controls stability and molecular flux in engineered protein cages biorxiv.org/cgi/content/shor… #bioRxiv
Giessen Lab retweeted
☕ Morning coffee ✅
New review on Encapsulin nanocompartments from @GiessenLab ✅
onlinelibrary.wiley.com/doi/…
Giessen Lab retweeted
I'll be giving a talk next Wed on some of our latest unpublished work on #encapsulin cages by lab superstars @nurentasneem and Lachlan - come watch!
Keen to hear opinions of any supramolecular folks (and others) who may be watching...
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Giessen Lab retweeted
If I think of cases that I have heard of, a combination of 1), 2), 3) and 4) was needed before articles were retracted. If you want colorful stories, the Tiwari case is some hours of reading forbetterscience.com/2018/01…
Another one is the "Schön affair"
cen.acs.org/articles/89/i51/…
Giessen Lab retweeted
I wrote about the new coronavirus itself--where it came from, why it's behaving in the way it's behaving, how it infects and kills, and what the summer might bring. It's early days, of course, but this serves as a rough preliminary portrait of SARS-CoV-2. theatlantic.com/science/arch…
Giessen Lab retweeted
Will Cryo-Electron Microscopy Shift the Current Paradigm in Protein Structure Prediction? dx.doi.org/10.1021/acs.jcim.…
Giessen Lab retweeted
Just to help the conspiracy theories stay appropriately debunked: “Our analyses clearly show that SARS-CoV-2 is not a laboratory construct or a purposefully manipulated virus.”
Where did #COVID19 come from and evolve -> human-to-human transmission? The genomic detectives look at all we know and call out the things we need to find out nature.com/articles/s41591-0…
@NatureMedicine by @K_G_Andersen @arambaut and colleagues
Giessen Lab retweeted
Luke and Benz's new paper on the intrinsically disordered repeat protein, Csos2, that brings the carboxysome together; a summary thread!
nature.com/articles/s41594-0…
Giessen Lab retweeted
Working on #cryoEM from home? 🏡 Check out this quick guide on options for accessing #cryoSPARC remotely: cryosparc.com/blog/remote-ac…
Giessen Lab retweeted
Hello Twitter... we're hiring! My lab at @SydneyChemistry has an open #postdoc position to work on protein engineering and catalysis in synthetic organelles.
Please RT!
findapostdoc.com/search/job-…
Giessen Lab retweeted
The blue curve is bad. The yellow curve, not so bad.
What can we all do to make sure we keep #coronavirus cases at a manageable level? And will it really work? We asked a historian who studies epidemics: healthblog.uofmhealth.org/we…
