@GiusToLab

Assistant Professor of Neurology @ColumbiaMed #PopulationGenetics #Epidemiology #Neuroscience #Alzheimer #ENDALZ 🏳️‍🌈

 New York, NY
neurology.columbia.edu/research/research-labs/giusto-lab
Joined October 2021
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Replying to @RuhelaVivek
@RuhelaVivek presenting at #adpd2026
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Check out our lab's latest software! 𝗦𝗔𝗚𝗔 runs 𝗴𝗲𝗻𝗼𝗺𝗲𝘄𝗶𝗱𝗲 𝗮𝘀𝘀𝗼𝗰𝗶𝗮𝘁𝗶𝗼𝗻 𝗮𝗻𝗮𝗹𝘆𝘀𝗲𝘀 with a simple one-line command! Anyone can access complex genetic analyses 🙌 [developed by the talented Basilio Cieza] 📌biorxiv.org/content/10.1101/…

SAGA (Simplified Association Genome-wide Analyses): a user-friendly Pipeline to Democratize...

Genome-wide association studies (GWAS) have enabled clinicians and researchers to identify genetic variants linked to complex traits and diseases([1][1]–[3][2]). However, GWAS still face several...

biorxiv.org
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Africa is making history with its first large-scale Alzheimer’s datasets 🧠✨ Read more in the link!
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Presenting my preliminary results of APOE e4 and Ptau 217 over cognition in quechua and aymara population from GAPP study at #AAIC25 in Toronto. Thanks to @GiusToLab, @NiltonCustodio8 @marciosotoanari
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How does APOE status impact AD risk in Hispanics/Latinos? Research in A&D report APOE ε4 shows a heterogeneous effect on ADRD risk across Hispanic/Latino populations, with the strongest associations in Peruvians/Bolivians #AlzResearch alz-journals.onlinelibrary.w…
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𝘼𝙋𝙊𝙀-ε4 and ε2 effect in Alzheimer's Disease varies across populations! Check our findings in the largest collection of Hispanics/Latinos now published in @alzdemjournals 📰 alz-journals.onlinelibrary.w…
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What does heritability mean as measured multiple ways and what does it mean for our understanding of Alzheimer's? Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates for binary traits, a systematic review medrxiv.org/content/10.1101/…

Alzheimer disease is (sometimes) highly heritable: Drivers of variation in heritability estimates...

Estimating heritability has been fundamental in understanding the genetic contributions to complex disorders like late-onset Alzheimer’s disease (LOAD), and provides a rationale for identifying...

medrxiv.org
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Replying to @panomics
🙏🙏🙏
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Took a minute (4+ years😅), but we made it! We studied the heterogeneity of APOE and Alzheimer's Disease risk using the largest collection of Hispanic/Latino studies - an amazing collective effort🎉 alz-journals.onlinelibrary.w…
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v nice thread
Sasha Gusev
@SashaGusevPosts28 Mar 2025
I wrote about how population stratification in genetic analyses led to a decade of false findings and almost certainly continues to bias emerging results. But we are starting to have statistical tools to sniff it out. A 🧵:
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Congrats to our star clinical coordinator Jennifer Ortega Morales - she matched yesterday for the Internal Medicine Residency Program! #proudPI
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a great collaboration with @NiltonCustodio8 @RosaMontesino18 @marciosotoanari
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Finally out our paper on ptau217 and AD in Peruvian populations! A huge effort for the GAPP study, an exceptional cohort of participants from Lima, Arequipa and Puno with deep phenotyping, genetics, plasma and serum available for the scientific community! alzres.biomedcentral.com/art…
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Closing day at the Brain Ageing and Dementia in LMICs 2024 conference in Nairobi, Kenya 🇰🇪 Dr. @pericakvance taking the stage to present our @NIHAging funded DAWN study for which we have been recruiting thousands of seniors in US and Africa thedawnstudy.com
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see you in Vienna! #ENDALZ 🗓️program here: adpd.kenes.com/scientific-pr…
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come work with us! #HiringNow #postdoc #postdocappreciationweek #columbia #genetics #ENDALZ #Neuroscience ✏️linkedin.com/jobs/view/40322…
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We now have a zebrafish model 🐟 to better dissect the genetics underpinning Fetal Alcohol Spectrum Disorders #FASD - thanks to @CaKizil @gaattagca @NIAAAnews preprint here 👇🏼 biorxiv.org/content/10.1101/…

Ethanol exposure model in zebrafish causes phenotypic, behavioral and gene expression changes that...

Fetal Alcohol Spectrum Disorders (FASD) represent a significant global health challenge, characterized by physical and neurodevelopmental abnormalities in offspring resulting from prenatal alcohol...

biorxiv.org
GiusTo Lab@GiusToLab1 Apr 2024
A new project from our lab! Fascinating #admixture study on this underrepresented South African population and the risk profile for Fetal alcohol spectrum disorders #FASD. 1% to 5% of U.S. first graders have FASD! @NIAAAnews medrxiv.org/content/10.1101/…
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Check out our poster #338 showing the performance of ptau-217 for #Alzheimer in a large South American cohort #AAIC2024 #biomarkers
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Living our best life with AAIC boxed lunch 😂
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Join us today at 4:15 pm EST! #AAIC2024
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