Prof Dino Giussani's lab @Cambridge_Uni and @PDN_Cambridge. We study how the environment during pregnancy and early life programmes heart disease in later life.

Joined January 2019
๐Ÿ†Congratulations to @DrWenTong, winner of our 2025 #EarlyInvestigatorPrize in the General category! Her award-winning paper reveals how placental mitochondria adapt to maintain energy balance during gestational hypoxia. ๐Ÿ“– Read it here๐Ÿ‘‡๏ธ buff.ly/Ps5c29V
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It's time to nominate the next leaders of SRI! Please log in to your SRI account today to submit your nominations. The positions up for nomination: - Presidential Nominee - Vice President for Strategic Initiatives - Council Member - *NEW!* SRI International Council Member
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Natural daylight and improved glucose control in Type 2 diabetes cell.com/cell-metabolism/fulโ€ฆ @Cell_Metabolism
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Congratulations to Zhongchao Wang from @PDN_Cambridge for winning the Early Investigator Prize 2024 in the #General physiology category! ๐Ÿ”Ž ๐Ÿ† ๐Ÿ“œ Read the winning paper here: buff.ly/rj9JfAp ๐Ÿ”— See the full list of winners: buff.ly/HnHdfqa
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Hamilton et al found hyperactivity of the cardiac #RyR promotes structural remodeling of #mitochondria. Learn how preventing mitochondrial remodeling can attenuate calcium-dependent #arrhythmia at ahajrnls.org/3Kw6fMp @S_HamiltonLab @jinxi_wang22 @OhioStatePCB
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Congratulations to Dr Anna Cochrane! Our newly minted doctorate from the Giussani Lab at University of Cambridge, who passed her PhD viva with flying colours! I couldnโ€™t be prouder of Annaโ€™s work investigating obesity in pregnancy and its effects on the fetus. ๐Ÿคฉ
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101 Questions to Ask Your Papers #Ad
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A recent study (shared below) reminded me that ๐ฐ๐ก๐š๐ญ ๐ฆ๐š๐ค๐ž๐ฌ ๐š ๐๐ก๐ƒ ๐ฌ๐ญ๐ฎ๐๐ž๐ง๐ญ ๐ก๐š๐ฉ๐ฉ๐ฒ ๐ข๐ฌ ๐ง๐จ๐ญ ๐ฉ๐ฎ๐›๐ฅ๐ข๐œ๐š๐ญ๐ข๐จ๐ง๐ฌ ๐จ๐ซ ๐ฌ๐ญ๐ข๐ฉ๐ž๐ง๐๐ฌ, ๐›๐ฎ๐ญ ๐ ๐จ๐จ๐ ๐ฌ๐ฎ๐ฉ๐ž๐ซ๐ฏ๐ข๐ฌ๐ข๐จ๐ง. Over the years, I have supervised 53 PhD students, and I can say with conviction that ๐˜๐—ต๐—ฒ๐—ฟ๐—ฒ ๐—ถ๐˜€ ๐—ป๐—ผ ๐˜€๐—ถ๐—ป๐—ด๐—น๐—ฒ ๐˜€๐˜‚๐—ฝ๐—ฒ๐—ฟ๐˜ƒ๐—ถ๐˜€๐—ผ๐—ฟ๐˜† ๐˜€๐˜๐˜†๐—น๐—ฒ that works for all. Each student is different, and every PhD journey has its ups and downs. With some students, I spent a disproportionate amount of time helping them gain confidence. With stronger ones, my role was to ๐—ด๐˜‚๐—ถ๐—ฑ๐—ฒ ๐˜๐—ต๐—ฒ๐—บ ๐˜‚๐—ป๐˜๐—ถ๐—น ๐˜๐—ต๐—ฒ๐˜† ๐—ณ๐—ผ๐˜‚๐—ป๐—ฑ ๐˜๐—ต๐—ฒ ๐—ฟ๐—ถ๐—ด๐—ต๐˜ ๐—ฝ๐—ฟ๐—ผ๐—ฏ๐—น๐—ฒ๐—บ ๐—ฎ๐—ป๐—ฑ ๐—ฏ๐—ฒ๐—ฐ๐—ฎ๐—บ๐—ฒ ๐˜€๐—ฒ๐—น๐—ณ-๐—ฑ๐—ฟ๐—ถ๐˜ƒ๐—ฒ๐—ป. ๐—˜๐—บ๐—ฝ๐—ฎ๐˜๐—ต๐˜† ๐—บ๐—ฎ๐˜๐˜๐—ฒ๐—ฟ๐˜€. Unless a student gets genuinely interested in what he or she is doing, great work rarely happens. A good ๐˜€๐˜‚๐—ฝ๐—ฒ๐—ฟ๐˜ƒ๐—ถ๐˜€๐—ผ๐—ฟ ๐—บ๐˜‚๐˜€๐˜ ๐—ฎ๐—น๐˜€๐—ผ ๐—ต๐—ฎ๐˜ƒ๐—ฒ ๐—ด๐—ผ๐—ผ๐—ฑ ๐—ฟ๐—ฒ๐—น๐—ฎ๐˜๐—ถ๐—ผ๐—ป๐˜€๐—ต๐—ถ๐—ฝ๐˜€ ๐˜„๐—ถ๐˜๐—ต ๐—ฐ๐—ผ๐—น๐—น๐—ฒ๐—ฎ๐—ด๐˜‚๐—ฒ๐˜€. I never restricted my students from seeking advice from other faculty. In fact, I always encouraged it and built a network they could freely approach. I also followed an ๐—ผ๐—ฝ๐—ฒ๐—ป-๐—ฑ๐—ผ๐—ผ๐—ฟ ๐—ฝ๐—ผ๐—น๐—ถ๐—ฐ๐˜† - any student could walk into my office anytime for advice. I never had a lab of my own in any institution I worked at. Instead, I built common labs, shared by all, to promote collaboration and collective ownership. I have always believed that the ๐—ฏ๐—ฒ๐˜€๐˜ ๐—ฟ๐—ฒ๐˜€๐—ฒ๐—ฎ๐—ฟ๐—ฐ๐—ต ๐—ฒ๐—ป๐˜ƒ๐—ถ๐—ฟ๐—ผ๐—ป๐—บ๐—ฒ๐—ป๐˜๐˜€ ๐—ฎ๐—ฟ๐—ฒ ๐˜๐—ต๐—ผ๐˜€๐—ฒ ๐˜„๐—ต๐—ฒ๐—ฟ๐—ฒ ๐—ฝ๐—ฒ๐—ผ๐—ฝ๐—น๐—ฒ ๐—ฎ๐—ป๐—ฑ ๐—ณ๐—ฎ๐—ฐ๐—ถ๐—น๐—ถ๐˜๐—ถ๐—ฒ๐˜€ ๐—ฎ๐—ฟ๐—ฒ ๐˜€๐—ต๐—ฎ๐—ฟ๐—ฒ๐—ฑ, ๐—ป๐—ผ๐˜ ๐—ผ๐˜„๐—ป๐—ฒ๐—ฑ. I have always taken ๐—ฝ๐—ฒ๐—ฟ๐˜€๐—ผ๐—ป๐—ฎ๐—น ๐—ฟ๐—ฒ๐˜€๐—ฝ๐—ผ๐—ป๐˜€๐—ถ๐—ฏ๐—ถ๐—น๐—ถ๐˜๐˜† ๐—ณ๐—ผ๐—ฟ ๐—ฒ๐—ป๐˜€๐˜‚๐—ฟ๐—ถ๐—ป๐—ด ๐˜๐—ต๐—ฎ๐˜ ๐—บ๐˜† ๐—ฃ๐—ต๐—— ๐˜€๐˜๐˜‚๐—ฑ๐—ฒ๐—ป๐˜๐˜€ ๐—ณ๐—ถ๐—ป๐—ฑ ๐˜๐—ต๐—ฒ๐—ถ๐—ฟ ๐—ณ๐—ถ๐—ฟ๐˜€๐˜ ๐—ท๐—ผ๐—ฏ ๐—ฎ๐—ณ๐˜๐—ฒ๐—ฟ ๐—ด๐—ฟ๐—ฎ๐—ฑ๐˜‚๐—ฎ๐˜๐—ถ๐—ผ๐—ป. Since most of them worked on industry-supported projects, this was never a problem. Nearly 90% of my PhD students wrote their first peer-reviewed paper with me. Unlike in the US, where professors often get students with prior research experience, ๐—ถ๐—ป ๐—œ๐—ป๐—ฑ๐—ถ๐—ฎ ๐˜„๐—ฒ ๐˜„๐—ผ๐—ฟ๐—ธ ๐˜„๐—ถ๐˜๐—ต ๐—ฟ๐—ฎ๐˜„ ๐˜๐—ฎ๐—น๐—ฒ๐—ป๐˜ ๐—ฎ๐—ป๐—ฑ ๐—ต๐—ฒ๐—น๐—ฝ ๐˜€๐—ต๐—ฎ๐—ฝ๐—ฒ ๐˜๐—ต๐—ฒ๐—บ ๐—ถ๐—ป๐˜๐—ผ ๐—ฐ๐—ฎ๐—ฝ๐—ฎ๐—ฏ๐—น๐—ฒ ๐—ฟ๐—ฒ๐˜€๐—ฒ๐—ฎ๐—ฟ๐—ฐ๐—ต๐—ฒ๐—ฟ๐˜€. Faculty in Indian institutions (at least in the institutions where I worked so far - IIT Bombay, IIT Delhi and BITS Pilani) often put in far more time and effort per student than many of our counterparts abroad. The ๐—ฟ๐—ฒ๐—ฎ๐—น ๐—ฟ๐—ฒ๐˜„๐—ฎ๐—ฟ๐—ฑ ๐—ฐ๐—ผ๐—บ๐—ฒ๐˜€ ๐—ณ๐—ฟ๐—ผ๐—บ ๐˜€๐—ฒ๐—ฒ๐—ถ๐—ป๐—ด ๐˜€๐˜๐˜‚๐—ฑ๐—ฒ๐—ป๐˜๐˜€ ๐˜๐—ฟ๐—ฎ๐—ป๐˜€๐—ณ๐—ผ๐—ฟ๐—บ ๐—ถ๐—ป๐˜๐—ผ ๐—ฐ๐—ผ๐—ป๐—ณ๐—ถ๐—ฑ๐—ฒ๐—ป๐˜ ๐—ฟ๐—ฒ๐˜€๐—ฒ๐—ฎ๐—ฟ๐—ฐ๐—ต๐—ฒ๐—ฟ๐˜€, ๐—ถ๐—ป๐—ป๐—ผ๐˜ƒ๐—ฎ๐˜๐—ผ๐—ฟ๐˜€, ๐—ฎ๐—ป๐—ฑ ๐˜๐—ฒ๐—ฎ๐—ฐ๐—ต๐—ฒ๐—ฟ๐˜€. That makes everything worthwhile.
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GiussaniLab retweeted
The US DOHaD Society is looking forward to attending the 13th DOHaD World Congress in Buenos Aires, Argentina! Will we see you there? Check out our latest post with a quick survey to help you meet up with other US DOHaD Society Members: usdohad.org/2025/08/20/conneโ€ฆ
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Sudhahar & colleagues found #exercise protects blood vessel in #diabetes by turning on natural #antioxidants (#SOD3) that produce physiological levels of hydrogen peroxide to keep blood vessels healthy. Learn more at ahajrnls.org/3IU4wz5
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Free for all Eurodohad members! Join us for this hybrid meeting. Donโ€™t miss this great opportunity to connect and network
Last chance to register!โฐ @EuropeanDOHaD Society presents MIREDA โ€“ harmonising UK birth cohort data through OMOP! Dive into the OMOPed dataset, attend exciting workshops & shape future maternal & infant health research. Don't miss out! ๐Ÿ”—eventbrite.co.uk/e/european-โ€ฆ @HDR_UK
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We're here, looking forward to welcoming everyone for day 1 of our annual meeting 'The Placenta at Term' @ChurchillCol
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Don't loose this opportunity to join us in Buenos Aires! Late-Breaking Abstract Submission ends on July 14. @DOHaD2025 @DOHaD_Society @DOHaDChile @BrasilDohad @EuropeanDOHaD @USDOHaD @Dohadcanada
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Our latest report highlights an important window of opportunity in the first 1,000 days of life to prevent childhood obesity and set children on a healthy path for life. ๐Ÿ—ž๏ธ Read @DailyMail for more: bit.ly/4lzIAr6 ๐Ÿ“™ See the full report: bit.ly/4eAt6ku
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How much does severe earlyโ€onset fetal growth restriction cost for hospitals & parents? Find out here in our economic assessment obgyn.onlinelibrary.wiley.coโ€ฆ Of 135 births, 46% were extremely preterm <28+0โ€‰weeks, costing an extra mean ยฃ157โ€‰832 per infant compared to term birth @ucl
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This highlights the need for long-term cardiovascular follow up in offspring (of both sexes!) from human metformin-treated pregnancies to inform decisions about its use in pregnancy - a tricky question that requires balancing mum and baby's health ๐Ÿ‘ฉโ€๐Ÿผ
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GiussaniLab retweeted
Membership renewal is now available! Be sure to renew your membership by June 30th to keep your member status & continue receiving member benefits. Renew simply by logging into your SRI account, selecting the 'Dues' tab on your dashboard, & continuing to renew your membership!
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We were delighted to host the @Cambridgecardio monthly talk with guest speaker Norbert Weissmann from @jlugiessen discussing; Tobacco smoke-induced pulmonary hypertension & lung emphysema.
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๐Ÿ‘ฅMeet our Members!๐Ÿ‘ฅ Dr. Emmanuel Amabebe is a researcher at UTMB Galveston studying molecular pathways behind preeclampsia, preterm birth & more. Dr. Amabebe is a part of the Menon lab & teaches reproductive biology & physiology to both undergraduate & postgraduate students.
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