@GordFishell

labs at HMS Neurobiology and the Stanley center at the Broad, doing our best to understand cortical interneurons through developmental genetics and physiology.

 Boston, MA
fishelllab.hms.harvard.edu
Joined February 2017
  • Tweets940
  • Following1.2K
  • Followers5.8K
21Media
Had my first publication with my son Will Fishell ....and my second on using SNNs and inhibition to improve AI computation with Suraj Honnuraiah iopscience.iop.org/article/1…

Feedforward spiking neural networks are not transformers (yet): a learning-theoretic framework for...

Feedforward spiking neural networks are not transformers (yet): a learning-theoretic framework for long-range dependencies and biological efficiency, Fishell, William, Fishell, Gord, Honnuraiah, Suraj

iopscience.iop.org
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Met this fellow at a party of my sons. Bright guy with good ideas. Worth a read.
Liam Davis
@liamjdavis146Jun 1
Small recurrent transformers like TRM and HRM have shown great promise. We introduce the Lattice Deduction Transformer, a recurrent transformer grounded in abstract interpretation. Using symbolic lattice structures, the model learns to approximate sound logical deduction.
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Thoughts on Anthropic and the pentagon....The US military has 3000 strikes in Iran, all determined using Claude's help -assume 94% accuracy and 0 hallucinations. So 180 errors in targeting. How many civilians are killed in those errors? That is why we can't autonomize warfare!
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Chandelier baby… Now you're talking! Well done, Ethan!!
Ethan Goldberg@Go3thanFeb 3
New study led by postdoc Sophie Hill in collaboration @GordFishell @YatingWang1 et al: Developmental dysregulation of chandelier cell excitability in a mouse model of Dravet Syndrome biorxiv.org/content/10.64898…
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Excited to be on the organization meeting for the 6th annual NCM conference on Neural Circuits in Health & Disease. Terrific line up of speakers!
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Excited for the publication of our recent work on how pyramidal cells shape the identity of interneurons in the Cortex! Big shout out to @artofbiology and Sherry Jingjing wu! nature.com/articles/s41586-0…
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Pay attention to the amazing tool set that Min has assembled! Central in the analysis of our recent Nature work! nature.com/articles/s41586-0…
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Thrilled to see our PNAS paper featured in @GiacomoI commentary. A fantastic recognition of how biologically grounded cortical microcircuits can accelerate the next generation of NeuroAI—and a meaningful step connecting it to neuroscience pnas.org/doi/10.1073/pnas.25…

Biological fidelity: The engine driving the neuromorphic renaissance | PNAS

Biological fidelity: The engine driving the neuromorphic renaissance

pnas.org
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Gord Fishell retweeted
Min Dai
@artofbiology30 Nov 2025
Excited to share our new preprint! LARIS enables accurate and efficient ligand and receptor interaction analysis in spatial transcriptomics biorxiv.org/content/10.1101/… Joint work from Fishell lab @GordFishell and Fei Chen lab @insitubiology @sundakao at the Broad @broadinstitute 1/n
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Excited to report the publication of LARIS, a program that can predict spatiotranscriptic LIgand-Receptor interactions. This work was led by @artofbiology (Min Dai in my lab) with Fei Chen's lab at the Broad. biorxiv.org/content/10.1101/…

LARIS enables accurate and efficient ligand and receptor interaction analysis in spatial transcri...

Advances in spatially resolved transcriptomics provide unprecedented opportunities to characterise intercellular communication pathways. However, robust and computationally efficient incorporation of...

biorxiv.org
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And now the Neuromorphic piece has been picked up a one of the 10 most notable AI papers this week! Exciting! Well done Suraj!! aiworld.eu/story/this-weeks-…

This Week's 10 Most Notable AI Research Papers - Week 41

This week’s AI research highlights how technological innovation and societal responsibility are increasingly intertwined. Studies range from AI-driven advanc...

aiworld.eu
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Well to complement my son's efforts here is some background into my own first foray into neuromorphic computing. The original article can be seen in PNAS! A big shout out to Suraj Honnuraiah, who made it all happen!. growkudos.com/publications/1…

Using canonical cortical circuits as a prefilter to improve AI transformer performance.

Our brains are remarkably good at recognizing patterns, generalizing to new situations, and filtering important signals from background noise while using very little energy. This study identifies...

growkudos.com
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Well when it rains it pours. My son Will @fishell_will , just published a paper on biorxiv, much closer to my heart with my lab member Suraj Honnuraiah on spiking neural networks and understanding why they struggle as LLMs. biorxiv.org/content/10.1101/…

SNNs Are Not Transformers (Yet): The Architectural Problems for SNNs in Modeling Long-Range...

Spiking neural networks (SNNs) have attracted growing interest for their ability to operate efficiently on low-power neuromorphic hardware, offering a biologically grounded route toward energy-effi...

biorxiv.org
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In a whimsical review of his arXiv.org paper, my son Will discusses the use of TempoBench in evaluating LLMs. I particularly enjoyed the faux ad for the TempoBench "product". You go Will! wfishell.github.io/landing.h…
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Really excited to see my son Will @fishell_will publish his first work Tempobench that measures temporal causality and reasoning in LLMs. arxiv.org/abs/2510.27544

TempoBench: Reasoning Execution Without Causal Attribution Is Just...

Current training paradigms, optimized for long-horizon reasoning trace execution, have made Large Language Models (LLMs) excel at pattern matching and forward simulation of reasoning, but...

arxiv.org
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Updated how pyramidal neurons impact specific interneuron subtypes. Turns out spontaneous activity, Wnt signaling in Parvalbumin Interneurons and integrin-signaling in Somatostatin neurons are the culprits! Also see how optimal transport tracks identity.biorxiv.org/content/10.1101/…

Pyramidal neurons proportionately alter the identity and survival of specific cortical interneuron...

The mammalian cerebral cortex comprises a complex neuronal network that maintains a precise balance between excitatory pyramidal neurons and inhibitory interneurons. Accumulating evidence indicates...

biorxiv.org
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Outside my usual comfort zone. This is the amazing work of Dionnet Bhatti a graduate student who examined the defensive behavior mediated lateral septum through careful SC analysis of the CRHR2 populations. Dionnet is someone you should keep your eyes on! researchsquare.com/article/r…

Feature-specific threat coding in lateral septum guides defensive action

The ability to rapidly detect and evaluate potential threats is essential for survival and requires the integration of sensory information, with internal state and prior experience. The lateral...

researchsquare.com
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At my last year of attending the McKnight conference. Such an amazing group of scientists. A big shout out to Lauren Orefice @lauren_orefice who gave an amazing talk this morning!
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Here is a chat with Bosilijka Tasic and myself about the enhancer-mediated AAVs that we were both centrally involved in publishing. I truly believe these approaches are fundamentally important for both basic and clinical approaches! braininitiative.nih.gov/news…

The BRAIN Initiative

nih.gov
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Gord Fishell retweeted
Neuron@NeuroCellPress21 May 2025
New Neuron issue! Discover methods for accessing neuronal and non-neuronal cell types in the CNS from the BRAIN Armamentarium Consortium 🧠🔧 Read insights from Bosiljka Tasic & @GordFishell: cell.com/neuron/fulltext/S08… Explore the full issue here: cell.com/neuron/current
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