@GothelfLab

Nucleic acid chemistry, organic synthesis, bioconjugation, biomolecular drugs, DNA-nanotechnology, biosensors.

 iNANO,Aarhus Uni, Denmark
inano.au.dk/about/research-groups/gothelf-lab/
Joined March 2017
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The work by Mads K. Skaanning and other members of our team on the self-assembly of (L)-acyclic threoninol nucleic acids into ultrasmall wireframe nanostructures was recently published in JACS. pubs.acs.org/doi/10.1021/jac…, @iNANO_AarhusUni, @Chemistry_AU

Self-Assembly of Ultrasmall 3D Architectures of (l)‑Acyclic Threoninol Nucleic Acids with High...

Abstract. The primary challenge of implementing DNA nanostructures in biomedical applications lies in their vulnerability to nuclease degradation and varia

pubs.acs.org
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Jakob Smidt from our lab visited Lennart Lykke @novonordisk during his PhD studies and the collaboration resulted in a method to conjugate GLP1 to any phosphate in siRNA. See the resulting paper in Nucleic Acids Research. academic.oup.com/nar/advance…. @iNANO_AarhusUni, @Chemistry_AU
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Reversible protection of DNA origami by a cationic disulfide polymer that is cleaved inside cells is reported in Small by Sarah Youssef @SarahYo45655307 and other members of our team. @iNANO_AarhusUni, @Chemistry, onlinelibrary.wiley.com/doi/…
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Triplex DNA blossoms on the front cover of Advanced Materials featuring our Triplex Origami methodology. The cover art is entirely made out of real folded paper! By postdoc @MinkieWinky and PhD student Emily Tsang. Read the article here: onlinelibrary.wiley.com/doi/…
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So far, DNA nanotech has almost exclusively relied on Watson-Crick base interactions. In our new paper in Advanced Materials, we show that Hoogsteen interactions have the same potential to organize double-stranded DNA. @iNANO_AarhusUni, @Chemistry, onlinelibrary.wiley.com/doi/…
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Congratulations to Minke Nijenhuis for winning the excellent student or post presentation award at FNANO2023, where she presented our work on triplex origami and we also had a reunion with two former GothelfLab members Zhao Zhang and Abhichart Krissanaprasit.
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"Automated Solid-Phase Oligo(disulfide) Synthesis" is now online in Angewandte Chemie and special thanks to Martin Frandsen and Alexander Sandahl who have led this work. onlinelibrary.wiley.com/doi/…
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Happy to share our recent preprint on folding double-stranded DNA into designed shapes with triplex-forming oligonucleotides: chemrxiv.org/engage/chemrxiv…
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Our latest paper on bioconjugation, that was made in collaboration with Novo Nordisk A/S, was selected for editors favourite recet articles over at OBC. pubs.rsc.org/en/content/arti… #Gothelflab #realtimechem #NovoNordisk #ChangingDiabetes
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Line and Malthe from the Gothelf Lab at #AarhusUni has spent the last 3 months in Copenhagen at the #BioInnovation Institute. If you're curious to hear what they've learned, you can watch at 15.30 using this link: youtube.com/watch?v=v0OykuR2… #Science #chemistry #bioscience

BII Demo Day

Enjoy the videos and music you love, upload original content, and share it all with friends, family, and the world on YouTube.

youtube.com
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Professor Kurt Gothelf ⁦@GothelfLab⁩: The DNA origami method will undoubtedly influence development of new medicine ⁦@AaltoUniversity⁩ ⁦@nantech2019⁩ aalto.fi/en/news/professor-k…
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A close collaboration between #NovoNordisk and our lab at #iNANO has resulted in a recent publication in #AngewandteChemie. #Science #Chemistry #biotech For more information and link to the article, please visit: inano.au.dk/about/news-event…
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PAPER: Researchers from the Gothelf lab has recently published a mini review in #ChemBioChem on how to design probes for affinity guided protein conjugation. #Chemistry onlinelibrary.wiley.com/doi/…

Considerations on Probe Design for Affinity‐Guided Protein Conjugation

Affinity-guided protein conjugation relies on noncovalent interactions between the probe and the protein prior to the conjugation reaction. This increases the local concentration of the reactive...

chemistry-europe.onlinelibrary.wiley.com
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PhD student Mette Riis Bakke from the @GothelfLab will be having her qualifying exam this Wednesday. phd.scitech.au.dk/currently/…
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Our most recent review about "Chemistries for DNA Nanotechnology" pubs.acs.org/doi/10.1021/acs…

Chemistries for DNA Nanotechnology

Abstract. The predictable nature of DNA interactions enables the programmable assembly of highly advanced 2D and 3D DNA structures of nanoscale dimensions.

pubs.acs.org
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Quantitative Detection of Digoxin in Plasma Using Small‐Molecule Immunoassay in a Recyclable Gravity‐Driven Microfluidic Chip - Li - - Advanced Science - Wiley Online Library onlinelibrary.wiley.com/doi/…
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Selective delivery of doxorubicin to EGFR+ cancer cells by Cetuximab‐DNA conjugates - Gothelf - - ChemBioChem - Wiley Online Library onlinelibrary.wiley.com/doi/…
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A new paper regarding affinity guided labelling by @Mortensen_M_R et al. Stay tuned for more! pubs.rsc.org/en/content/arti…
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Congratulations to Dr. Line Debois Frejlev Nielsen for achieving the PhD title! We wish you all the best for the years to come! #RealTimeChem #aarhusuni #DETECT
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Once again the Gothelf lab won the best decorated table competition at the iNANO Christmas lunch! This year we had a Christmas in space theme with Santa Kurt (Gothelf) in the sleigh and Darth Skrydstrup chasing him in the black fighter #DecoChamps #RocketDeers #iNANO #AU
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