Bacterial chromosome biology, gene expression, pathogenicity... and football. @graingerlab.bsky.social
Birmingham, UK
Joined January 2012
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If you're interested in doing a PhD we have a lot of potential projects available in the lab. Topics cover bacterial pathogens, antibiotic resistence mechanisms, and fundemental mechanisms of gene regulation. More details here findaphd.com/phds/?Keywords=… 🧪🥼🔬
A new pre-print out - we show that promoters and terminators of transcription are frequently coupled, throughout the bacteria, and that this is regulatory.
biorxiv.org/content/10.64898…
Bidirectional promoters in Escherichia coli: regulatory rules and implications for gene expression noise academic.oup.com/nar/article…
@emilywarmanj Bidirectional promoters in Escherichia coli: regulatory rules and implications for gene expression noise academic.oup.com/nar/article…
In our most recent work David Forrest has discovered a widespread mechanisms linking transcription initiation to DNA supercoiling...
nature.com/articles/s41467-0…
@emilywarmanj has followed up on her discovery of bidirectional promoters in bacteria by defining their basic rules for regulation and links to gene expression noise...
academic.oup.com/nar/article…
A busy few weeks for the lab 🥵... three new stories published. The first describes activation of transcription by DNA distortion
academic.oup.com/nar/article…
Our lab is offering 3 PhD projects this year across 3 different topics: antibiotic resistance mechanisms, evolution of pathogenic bacteria, and fundamental mechanisms of gene regulation.
findaphd.com/phds/?Keywords=…
@danielabarilla.bsky.social kicking off #BioPhyChrom2025 - a fantastic turn out too...
Talk slots full but we can take late breaking poster abstracts until August 7th. Hope to see you in York to hear about your chromosome story 🧬🦠🧫
eventsforce.net/biochemsoc/f...
If you're interested in chromosome biology (DNA folding, gene regulation, replication, polymer modelling and more) we're organising the below this autumn. It'd be great to see you there. Please share if you can. :-)
David Grainger retweeted
This infographic highlights the extreme lack of antibiotics available for treating mycoplasma infections compared to many other bacterial pathogens.
David Grainger retweeted
Congrats to all who make our School a great place to work and study, and to Carsten Kroger @KroegerLab and our EDI Committee for working on our successful submission. 👏👏👏😀 @tcddublin @TCDEquality #AthenaSWANIreland
David Grainger retweeted
We have 2 fully funded PhD studentships available through the new Yorkshire Biosciences DTP (starting Oct 25) - please share! Both projects are focussed on #phage that infect #Cdifficile
David Grainger retweeted
We're looking for an Assitant Professor in Microbiology to join us @tcdgenmicro! Come and join our growing team.
tcd.ie/microbiology/research…
tcd.ie/hr/vacancies/ Job ID: 037876. Closes 31st January
Giving these another airing... projects on bacterial pathogens, antimicrobial resistance, and basic mechanisms... all with a hint of gene regulation #PhD #opportunities
PhD projects available in our lab all listed in the below link. All focus on bacterial gene regulation, in the context of basic understanding, disease, or anitbiotic resistance. Deadlines in January...
findaphd.com/phds/?Keywords=…
I can highly recommend Paul's lab's stuff... and I bet a lot of you didn't know GTAs existed (I didn't).
We have a fascinating preprint just out, revealing the widespread packaging of bacterial genomic DNA into capsids in the human gut:bit.ly/3B2ajza. Major denizens of the #microbiome implicated with broad potential impact on bacterial evolution and horizontal gene transfer
ALT Concept summary of the approach used in the present study. A. Diagram of a caesium chloride gradient tube of VLPs purified from human faecal samples. Two bands of different densities are illustrated, followed by a flow chart of the Oxford Nanopore sequencing process and an illustrative chart showing read length distributions typical of phage, transducing phage particles and gene transfer agents. B. Distributions of read lengths obtained from six faecal VLP fractions.