Emmy Noether Research Group at the interface of pediatrics and reproductive potential | @dralexbusch

Münster
Joined March 2022
Most GWAS data come from adults. An amazing new resource from Japan (JECS) offers GWAS data on 1,148 traits from a birth cohort of 80,638 children. The traits range from pregnancy and neonatal outcomes to childhood diseases, and serial lab work, and anthropometrics.
3
34
2
130
18,263
Role of Genetics in the Age-Related Testosterone Decline in Men: A UK Biobank Study by Lynn Ogoniak @dralexbusch et al EJE Volume 193, Issue 2, August 2025 👉 doi.org/10.1093/ejendo/lvaf1… ESE Members free via 👉 my.ese-hormones.org #endocrinology #biobank #testosterone
5
7
657
Busch Group retweeted
🧬💥 Do the genetics that make you develop a disease also help you survive it? Not much. Our new @NatureGenet including 9 disease and 7 biobanks shows: • Susceptibility variants ≠ survival • PRSs for onset weak at predicting survival • Lifespan PRS predicts survival better
7
34
87
6,278
Serum steroid metabolome in infancy 👶 Longitudinal LC–MS/MS in 189 healthy infants maps 16 hormones + enzyme activity. We deliver sex- & age-specific reference curves to support earlier diagnosis of steroidogen. disorders. tinyurl.com/mueu83vj @ESEndocrinology @TheEndoSociety
1
3
105
#CoMICWednesday #EJECoMICs Ep 60: NEW @EJEndo paper: Role of genetics in the age-related testosterone decline in men: a UK Biobank study youtu.be/s8LFo8RR8f0 Full article doi.org/10.1093/ejendo/lvaf1… By @SimbaComics led by @rahulsagu6 @ESEndocrinology
8
12
868
To the 23andMe Community, I am incredibly excited and humbled to share with you that TTAM Research Institute (TTAM), a new non—profit medical research organization that I founded and lead, has completed the acquisition of 23andMe.   I formed TTAM and pursued the acquisition of 23andMe because of my strong belief that everyone should continue to have the ability to learn about and benefit from their DNA, and that a non-profit structure is the best way to solidify our values and commitments to our customers, the scientific community and the world at large. Since its founding in 2006, 23andMe has stood for something revolutionary: that individuals should have a right to understand themselves at the most fundamental level — through their DNA.   Through their DNA they can understand their health risks , prevent disease and be true partners in participating in research that shapes the future of health and medicine. Understanding the code of life - our DNA - is one of the most exciting scientific missions of our lifetime.  Through our DNA, we can learn about our ancestry origins, prevent potential health issues, and help develop treatments that could benefit all of us.   Humans are 99.5% genetically identical, and we have DNA in common with everything alive today.  The pursuit to understand DNA will benefit all of us and all of life. That belief built one of the world’s most diverse and engaged genetic research communities. More than 15 million people have joined this journey, and over 80% have chosen to participate in research, contributing to over 275 peer-reviewed publications in cancer, cardiovascular disease, neurological disorders, and more.   These discoveries did not just stay academic - those discoveries were also translated into new genetic reports  for customers that helped them continue to learn about their own DNA.    Thank you to the 23andMe community that participated in research and contributed to discoveries that have had a meaningful impact for the world. I want to end on a personal note.   Over the last few years I unfortunately lost my father, my nephew and my sister.   These tragedies have sharpened my focus on what is most important to me and how I want to spend my time.   My passion is 23andMe.  The opportunity to give back to society with our research and help everyone benefit from learning about their genome with a healthier life, is a personal mission where I am dedicating my resources and my time.    We all have a disease or health condition that we care about .  By coming together as a single community, we are stronger and more powerful to make discoveries and to ultimately make a difference.   The future of healthcare belongs to all of us and it’s in our power to make a difference. I am honored to be back with 23andMe and look forward to sharing more with you in the weeks and years to come. With gratitude, Anne
183
129
46
1,952
264,124
Reversal of congenital #hypogonadotropic #hypogonadism in two brothers carrying a homozygous KISS1 frameshift mutation thelancet.com/journals/landi… #CHH #FREE to read
2
14
1,663
Busch Group retweeted
We have reached a sale agreement with @Regeneron, a leading US-based biotechnology company, to carry forward 23andMe’s mission and maintain customer privacy protections. Read more about today’s announcement here: 23and.me/3ZoX2JT
39
64
34
241
90,734
Delighted to have been awarded an International Joint Project grant from @RoyalSocEd. This will fund 12 exchange visits between @EdinUni_IRR and @uni_muenster over the next 2 years. 👉 tinyurl.com/5n7fkvwa. Looking forward to enhancing 🏴󠁧󠁢󠁳󠁣󠁴󠁿 🇩🇪 collaborations @EdinUni_CRH 🕺💃
4
1
23
990
We are looking for you! To become a member of YARE is easy and gives you a lot of benefits. See the step-by-step below: •Easy peasy: use the registration form on the website, wait a few days (we do all manually!) and receive your certificate
1
5
8
845
I wrote about the latest attempt to sell genetic IQ prediction and why it is snake oil. A short 🧵:
28
266
45
1,185
442,810
Welcome to the 21st-century - check out our newly designed webpage: yare-endo.de and remember to sign up for our annual meeting together with our friends from @EYEScientists eyes-2023.com
1
1
4
395
🚀Launching #ReproTrackMS Exciting times as we kick off our Postdoc Programme aimed at setting emerging researchers on a trajectory towards academic careers🌟Join us in unraveling the mysteries of #reproductivescience #maleinfertility @BMBF_Bund @UK_Muenster @uni_muenster
Glückwunsch: 2,2 Mio € für die Erforschung ungewollter #Kinderlosigkeit: Bund fördert Nachwuchszentrum für reproduktive Gesundheit an Uni Münster und @UK_Muenster. @FTuttelmann @BMBF_Bund medizin.uni-muenster.de/faku…
4
18
2,143
Busch Group retweeted
Great news! You can now browse the #500KGenomes summary statistics for all UK Biobank participants free of charge using our Allele Frequency Browser. The browser was launched on behalf of the Whole Genome Sequencing consortium. 🧬afb.ukbiobank.ac.uk/
5
96
2
288
35,838
Long-read sequencing of millions of biobanked samples would be a powerful tool for target discovery, but isn't feasible today. But imputation is! Glad to have contributed to this long-read imputation panel w an impressive group at @Boehringer medrxiv.org/content/10.1101/…
1
33
105
14,377
We examined association of 414 early-life diseases on childlessness using registry data from: 1.04 Million (Finland) 🇫🇮 1.5 Million (Sweden) 🇸🇪 ...until the end of their reproductive life span
1
4
15
2,281
Busch Group retweeted
We are happy to announce release of FinnGen-UKBB meta-analysis results for 679 phenotypes at: public-metaresults-fg-ukbb.f… - enjoy browsing and downloading! #genomics #OpenScience
4
46
1
155
15,496