@GuptaLab_

Biochemistry and cellular structural biology laboratory @OHSUSOM | #NewPI @MeghnaG27

 Portland, OR
mguptalab.com/
Joined April 2023
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Happy to report a new TRPV1 agonist MSP20, which binds to the vanilloid site and desensitizes TRPV1. Our structural and preclinical studies highlight the potential of MSP20 as a long-lasting analgesic with neuroprotective effects. nature.com/articles/s41467-0…
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🏆 Biomedicines, Pharmaceutics & Pharmaceuticals are honoring 2025's best young investigators! Join the award ceremony on 22 May 2026, 17:00 CEST. Free access! 👉 sciforum.net/event/Topics-49
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Grateful to all our co-authors and collaborators: Sree Ganesh Balasubramani, Sasha Dickinson, Alexander Myasnikov, Ignacia Echeverria, Robert Stroud. Your expertise and support were invaluable to this work. Thanks to our funding sources- @NIHAging for K99/R00 and @AHAScience
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This work represents a major milestone in understanding how peroxisomal transporters function at the molecular level. Gupta lab members- @Nikk_click and Devin Seka made critical contributions that pushed this project forward. #NIHfunded #mguptalab #OHSU @OHSUNews
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Exciting holiday present for the Gupta lab! 🎉 🎊 Our paper "Molecular mechanism of substrate transport by human peroxisomal ABCD3" is now published in Proceedings of the National Academy of Sciences!! 🎉 🎊 @PNASNews pnas.org/doi/10.1073/pnas.25…

Molecular mechanism of substrate transport by human peroxisomal ABCD3 | PNAS

ATP-binding cassette transporters of the D subfamily (ABCD1-3) mediate the export of CoA thioesters of fatty acids from the cytosol into peroxisome...

pnas.org
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Molecular mechanism of substrate transport by human peroxisomal ABCD3 biorxiv.org/content/10.1101/… #biorxiv_biochem

Molecular mechanism of substrate transport by human peroxisomal ABCD3

Peroxisomes are eukaryotic oxidative organelles involved in numerous metabolic functions that include fatty acid oxidation, bile acid synthesis, and detoxification of reactive oxygen species....

biorxiv.org
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Dear cryo-EM women scientists, We want to honor you and your contributions at BPS 2025. This year, the Cryo-EM subgroup will honor a mid/senior-career woman scientist as the inaugural June Almeida awardee. June Almeida is the virologist who first discovered the coronavirus in 1967 using negative stain electron microscopy. Her story, like many women we know, is remarkable. womenshistory.org/education-… It is in the spirit of June Almeida’s innovative research that this award is named. The awardee, in addition to receiving an honorarium, will present their research at the BPS CryoEM Subgroup Symposium. The deadline for nominations for the Almeida Award is November 1st, and details of the award and the application process can be found at (biophysics.org/Awards-Fundin…). Nomination packets should be sent to [email protected]. Questions? Contact @OliBClarke, me, @MeghnaG27 @PilarCossio2 or @10feng ♥️We sincerely hope to see you at BPS 2025 in LA to celebrate achievements and advances in cryo-EM!
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Structure and inhibition mechanisms of Mycobacterium tuberculosis essential transporterefflux protein A biorxiv.org/cgi/content/shor… #biorxiv_biochem
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1/6 Happy to share our new preprint- biorxiv.org/content/10.1101/… @lab_stroud, @GuptaLab_, Jeffrey Bennett, @Nikk_click, Andrew Nelson, Peter Hwang, Sergei Pourmal. Huge thanks to the funding agencies @NIHgrants @guthyjacksonfdn @UCSF (pbbr.ucsf.edu/) for their support.

Structural Basis of Aquaporin-4 Autoantibody Binding in Neuromyelitis Optica

Neuromyelitis Optica (NMO) is an autoimmune disease of the central nervous system where pathogenic autoantibodies target the human astrocyte water channel aquaporin-4 causing neurological impairment....

biorxiv.org
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Structural basis of autoantibody binding in Neuromyelitis Optica biorxiv.org/cgi/content/shor… #biorxiv_immuno
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Structural basis of autoantibody binding in Neuromyelitis Optica | bioRxiv biorxiv.org/content/10.1101/…
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Congratulations to the 2024 fellows! 😃
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Congratulations Nitesh @Nikk_click 🎊🍾🎉 and Tomasiak lab!! nature.com/articles/s41467-0…
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Looking forward to #BPS2025! And to be part of organizing #CryoEM subgroup of the meeting.
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We are hiring! Please spread the word. postdoctoral-ohsu.icims.com/…
Meghna Gupta@MeghnaG276 Jun 2023
It is a pleasure to announce that I will be joining as a tenure-track Assistant Professor at Department of Chemical Physiology and Biochemistry, Oregon Health and Science University (OHSU) School of Medicine, Portland, OR @OHSUSOM
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It is a pleasure to announce that I will be joining as a tenure-track Assistant Professor at Department of Chemical Physiology and Biochemistry, Oregon Health and Science University (OHSU) School of Medicine, Portland, OR @OHSUSOM
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