@GygiLab

@harvardmed research group developing methods and tech in the fields of mass spectrometry and proteomics. Account managed by postdocs and student.

 Harvard Medical School
gygi.hms.harvard.edu/
Joined October 2019
  • Tweets376
  • Following133
  • Followers3.5K
5Media
I was quoted in this very well done story by @MaryKekatos at @ABC highlighting some of the grants that were tragically and needlessly terminated including mine. abcnews.go.com/US/350-harvar…

At least 350 Harvard medical grants were terminated by the Trump administration. Here are some of...

Grant terminations at Harvard have affected research on antibiotic resistance, identifying the earliest precursors of breast cancer and finding cures for ALS.

abcnews.com
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#ASMS2025 is fast approaching, and I'm looking forward to catching up with friends and seeing a lot of great mass spectrometry research. If you’re there, check out my Tuesday talk (TOE 3:10 PM) to learn how @HMSBioPlex is enhancing drug discovery! @harvardmed @asmsnews
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It’s also worth mentioning that the AP-MS data in this study was collected by the @HMSBioPlex team at @harvardmed.
Human Protein Atlas@ProteinAtlas29 May 2025
In a Nature article researchers from HPA and UCLA have used a machine learning approach that enables computational integration of protein localization data from IF images and AP-MS protein interaction data to create a MuSIC map of 5,100 proteins in U2-OS. proteinatlas.org/news/2025-0…
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Check out MuSIC 2.0, combining @ProteinAtlas images and @HMSBioPlex interactions to make a multi-scale model of the cell. I enjoyed working on this with @TreyIdeker, @Prof_Lundberg + their labs & collaborators. Special congrats to lead authors Leah Schaffer & @Clarararara_hu!
Clara (Mengzhou) Hu@Clarararara_hu9 Apr 2025
🚨 New in Nature @Nature! 🚨 Thrilled to be a co-first author on a global cell map built from U2OS protein imaging + interaction data 🧬🌐 📝 Paper: nature.com/articles/s41586-0… 🗺️ Visualization portal: musicmaps.ai/u2os-cellmap/

Multimodal cell maps as a foundation for structural and functional genomics

Nature - A global map of human subcellular architecture yields protein complex structures, reveals protein functions, identifies assemblies with multiple localizations or cell-type specificity and...

nature.com
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Collaborative efforts with @GygiLab, Hans Widlund, Kai Wucherpfennig Labs @DFCI_CancerBio @DanaFarber #HarvardCellBiology @bwhdermatology @harvardmed Be on the lookout for a 🧵by @TevisVitale for a more detailed explanation!
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I’m so grateful to have worked with these wonderful people on this awesome paper that came out in Cell today! Linking ALK phosphotyrosine signaling through GUK1 to regulate GDP/GTP levels in cancer. kwnsfk27.r.eu-west-1.awstrac… @HaigisLab @GygiLab @CellCellPress
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Check out this blog post and paper from Alberto Cruz-Martín, @rhushikeshphadk, and colleagues describing how @HMSBioPlex helped them link the complement pathway to synaptic dysregulation! communities.springernature.c… rdcu.be/dSTkf

Beyond Phagocytosis: The Intracellular Complement Pathway in Synaptic Dysregulation

In the last decade, research has highlighted the complement pathway's role in brain function, including synapse pruning and diseases. Our lab recently discovered a new intracellular pathway where...

communities.springernature.com
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Gygi Lab retweeted
Ka Yang@KaYangHMS19 Dec 2023
My work with @qingyuhms on our new TMT-ABPP at @GygiLab is now available online. The new method incorporating streamlined sample prep, TMT multiplexing and FAIMS-hrMS2 allows you to analyze ~18k cysteines across 18 samples starting from 10 ug proteome! sciencedirect.com/science/ar…
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Gygi Lab retweeted
Saei Lab
@AmirAta89 Aug 2024
Our multifaceted tool PISA-REX profiles the proteome of any given biosystem at the dimensions of protein solubility, expression and redox state, at high depth and throughput, for target deconvolution. Grateful to people at the @RZLabKI and the @GygiLab. onlinelibrary.wiley.com/doi/…

Multifaceted Proteome Analysis at Solubility, Redox, and Expression Dimensions for Target Identif...

Redox and EXpression (REX) is a high-throughput and high-depth proteomics approach that integrates the redox and expression facets. Combining REX with Proteome Integral Solubility Alteration (PISA)...

advanced.onlinelibrary.wiley.com
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Gygi Lab retweeted
Qing Yu@qingyuhms4 Jun 2024
Join our dynamic team! My lab @UMassChan is seeking postdocs passionate about creating cutting-edge intelligent quantitative (chemo)proteomics platforms. Let's decode protein function and develop novel therapeutics! DM me for a chat and apply at ummsjobs.com/job/10402/
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Good morning #ASMS2024! You don’t want to miss the excellent talks from my colleagues @EdHuttlin & @stshuken today! Plus, graduate student Kean and I have posters in today’s session- be sure to stop by 😎
Gygi Lab@GygiLab3 Jun 2024
If you're at #ASMS2024 in Anaheim, don't miss these exciting posters and oral presentations from @GygiLab members throughout the week!
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Good morning! I'm looking forward to presenting our latest @HMSBioPlex work combining PPI mapping with protein structure prediction using AlphaFold. Check it out in session MOH at 10:10 am!
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Do you want to hear about the latest developments in the @HMSBioPlex project? Check out @EdHuttlin's #ASMS2024 talk tomorrow: MOH 10:10. See you there!
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Please, check out our latest work from the King lab @rwkhms! Another nice collaboration with the @GygiLab and @PauloLabMS! If you suspect that your favorite protein could be a DUB substrate, take a look at our web app too!
Cell Chemical Biology@CellChemBiol28 May 2024
Specificity profiling of deubiquitylases against endogenously generated ubiquitin-protein conjugates by @VRossio, Randall W. King, and colleagues at @harvardmed @HarvardCellBio dlvr.it/T7WP0z #chembiol
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Steve Gygi @GygiLab investigador del departamento de biología celular en Harvard Medical School impartirá una conferencia titulada "Proteomics as a biological assay" 🗓️ Viernes 10 de Mayo 📍PRBB Auditorium (Barcelona)
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Congratulations to Matt McHenry & the entire team, including collaborators @realJimWells @GygiLab @jrengen @tmonsterphd, on the discovery of a covalent inhibitor of BAX, a blueprint for developing drugs to protect cells from unwanted cell death. nature.com/articles/s41589-0…

Covalent inhibition of pro-apoptotic BAX

Nature Chemical Biology - A disulfide tethering screen identified a molecule that covalently interacts with pro-apoptotic BAX at C126, inhibiting its activation.

nature.com
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If you like protein interactions, don't miss this paper from @HMS_BCMP members @ernstschmidd and Johannes Walter. They present a classifier that identifies confident AlphaFold structures of interacting proteins and use it to screen protein families in silico for new interactions!
This Post is from an account that no longer exists. Learn more
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We are committed to experimental profiling of protein interactions, but computational methods for predicting PPI are an important complement to our work. See this paper from @ernstschmidd and Johannes Walter to learn how they use AlphaFold to predict PPI's at scale! @HMS_BCMP
This Post is from an account that no longer exists. Learn more
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Excited to announce I’ve been awarded a T32 fellowship with @BidmcCvi! I’ll continue working in @LabSpiegelman & @GygiLab using proteomics to interrogate inter-organ signaling following exercise. Grateful for this opportunity to join an outstanding cohort & grow as a scientist.
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Excited to talk about my transition to @LabSpiegelman & @GygiLab on this panel with these amazing leaders in proteomics! @Keribackus @LisaMJonesLab1 @lkpino @us_hupo
Females in Mass Spectrometry (FeMS)@FemalesInMS23 Feb 2024
We are pleased to invite you to a panel discussion at the @us_hupo conference! We will focus on how to successfully navigate a career transition 👩‍🔬 We look forward to seeing you in Portland!
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