
Making the world aware of #HTLV and its global impact #HTLVAware
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ALT The mechanisms of activation of the canonical and non-canonical NF-κB pathways by Tax. (A) Tax activates IKK complex through association with IKKγ (NEMO) and TAK1. Tax also binds to RNF8 and LUBAC, generating polyubiquitin chains to facilitate association between TAK1 and IKK. Activated IKK complex phosphorylates IκB targeting it for proteasome-mediated degradation, thereby releasing NF-κB. Tax associates with IκB and releases NF-κB. Tax also associates with RelA and c-Rel to enhance transcription. (B) Tax associates with and activates IKKα to phosphorylate p100, triggering limited proteolysis and generating p52. Tax also associates with and activates NIK to activate IKKα.













