@Harry_Costello

@drharrycostello.bsky.social Academic neuropsychiatrist | MD PhD | Clinical Lecturer @UCLPsychiatry | Mood, Motivation & Neurodegeneration | Aspiring apiarist

 London
scholar.google.com/citations?user=31kYvdsAAAAJ&hl=en
Joined December 2009
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  • Followers1.3K
354Media
Delighted our (@jonroiser @ProfRobHoward @a_schrag @ymyymmr @karelkieslich) paper is now out in @Brain1878! 🎉 We show that #Parkinson's #depression may stem from a reduction in reward sensitivity that is unresponsive to dopaminergic medication: 🔗 doi.org/10.1093/brain/awaf09… 🧵⬇️

Impaired reward sensitivity in Parkinson's depression is unresponsive to dopamine treatment

Depression in Parkinson’s disease is common and disabling and often includes motivational symptoms such as apathy and anhedonia. Costello et al. show that

academic.oup.com
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Gus Hamilton@gushamiltonOct 23
We have a commentary out on some really interesting findings by colleagues in UCL and Finland on some of the maths behind some of the high profile shingles -> dementia analyses. In brief + Paper: pubmed.ncbi.nlm.nih.gov/4245… Commentary: kwnsfk27.r.eu-west-1.awstrac…

Natural experiments on herpes zoster vaccines and dementia - PubMed

Natural experiments on herpes zoster vaccines and dementia

pubmed.ncbi.nlm.nih.gov
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Margaret McCartney@mgtmccartneyOct 22
the @ASA_UK complaint I made was upheld about Do Health @drchatterjeeuk. Commercial screening brings false positives, false reassurance, overdiagnosis. Will the @gmcuk act on the dozens of drs making false claims and have commercial conflicts of interests?
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Doris Tsao
@doristsaoOct 17
1/ We discovered something totally unexpected about the neural structure of consciousness that overturns decades of thinking on its biological basis and brings us significantly closer to the recipe for generating conscious awareness. New preprint: biorxiv.org/content/10.64898… (led by @HesseJanis, with @FrankLanfranchi, @_conor_mcgrory, @Yuelin_Shi, and @EngelTatiana)

Rapid alternation of conscious and suppressed stimulus representations in the primate brain

The neural correlates of consciousness remain elusive[1][1]. Previous studies found that high-level visual cortex is weakly modulated by conscious perception[2][2],[3][3], yet a pure signal of...

biorxiv.org
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Eric Topol
@EricTopolSep 23
The GRAIL NHS Galleri randomized trial with over 142,000 participants was published today @NEJM "In this trial, we did not observe a lower incidence rate of stage III or IV cancers [the primary endpoint] across 12 prespecified cancers after three screening rounds with multicancer early-detection testing plus usual care than with usual care alone." nejm.org/doi/full/10.1056/NE…
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Tyler Black, MD
@tylerblack32Sep 9
Major release! =--=--=--=--= I have compiled the worlds largest database of pediatric suicide information, consisting of 137 countries, from 1952-2025. In total, 27.64 BILLION person-years of data are represented. /1
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NIK
@ns123abcSep 8
>math professor spends a year on one of the hardest unsolved problems in math >"Navier-Stokes" >his drafts for the whole project went through codex sessions >openai had his logs in codex >suddenly rumor leaks AI solved it >he emails openai to ask what's going on >openai calls within days >"funny story, our model also solved it" >using his exact approach >asks openai: did you train on my sessions? >no answer
etale27@etale27Sep 8
If I am reading this correctly, Tristan Buckmaster is alleging OAI has a resolution of Navier-Stokes(via Córdoba and Martínez-Zoroa’s program) which maybe used info from Buckmaster and Levent Alpöge’s private Codex sessions What the fuck is happening!!!
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Channel 4 News
@Channel4NewsSep 3
Exclusive: Nigel Farage filmed undercover celebrating secret new foreign donations Undercover footage verified by Channel 4 News reveals a secret plot by senior Reform UK figures to break the law on party donations. A leading legal expert is now calling for a criminal investigation. 🔗 Read the exclusive story on Substack: channel4news.substack.com/p/…
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Verbatim
@Verbatim_MediaSep 3
Our yearlong investigation reveals Nigel Farage courting illicit funding as part of a plot to bring foreign money into British politics, orchestrated by his top aides and caught on hidden camera.
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Channel 4 News
@Channel4NewsSep 3
Coming tonight: Channel 4 News and @Verbatim_Media reveal an undercover investigation inside Reform UK. Watch at 7pm on Channel 4 or YouTube.
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Alan Carson@AlanCarson15Aug 24
I have a concern we may be looking at misdiagnosed cases of functional cognitive disorders here- particularly given the example of not being able to walk but just not enough information to make any judgments in any direction
nature
@NatureAug 23
This controversial surgery for Alzheimer's patients aims to improve drainage of fluid from the brain. What do we know about it? go.nature.com/4gjBV3h

A controversial Alzheimer’s surgery is said to reverse symptoms — here’s what scientists know

Nature - Jaw-dropping patient videos and miraculous testimonials ignited a frenzy in China over a technique that aims to improve drainage from the brain. Now it is entering trials worldwide.

nature.com
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Eric Topol
@EricTopolAug 19
The mRNA vaccine success vs melanoma in a Phase definitive 3 randomized trial today is on top of signs of success for personalized mRNA neoantigen vaccines vs pancreatic cancer, triple negative breast cancer, and non-small cell lung cancer wsj.com/health/pharma/modern…

Moderna Shares More Than Double on Success of mRNA Cancer Vaccine

Result in high-risk patients validates decades of research into mRNA-based therapeutic cancer vaccines.

wsj.com
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Matt Burke@MattBurkeMDAug 18
Massive study published yesterday in @NatureHumBehav for anyone in the neuropsychiatry/mind-brain-behavior spaces Direct in vivo evidence for how attention can modulate the immune system in ways that seem almost unbelievable nature.com/articles/s41562-0…

Voluntary attention regulates acute immune responses in humans

Nature Human Behaviour - Mizrachi et al. show that directing attention to bodily sensations, rather than away, promotes more regulated acute inflammatory responses in healthy volunteers, revealing...

nature.com
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But…it was the opposite, I developed a low-cost Covid vaccine technology that actually bypassed big pharma. We did this at $2-4 per dose, reached 100 million people, saved an estimated 300,000-500,000 lives. I made nothing. It’s incredible to watch people cede all their critical thinking skills to conspiracy sites. This is how totalitarian and communist regimes thrive
DEER LORD@ohmstoneJul 30
Replying to @TulsiGabbard
Do not forget Pfizer and Dr. Mrna Hotez.. crimes against humanity while raking in millions.
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A long thread on a quasi experimental study modelled on the @Nature paper using Welsh data and suggesting live shingles vaccine protects against dementia. Sadly in 20 times the sample size using precisely the same quasi experimental design we showed no such apparent protection
Gus Hamilton@gushamiltonJul 22
Does the (live) shingles vaccine protect against dementia? We provide important evidence in a new preprint using hospital data from the whole of England in a regression discontinuity design where we *don't* show strong evidence of a causal effect +
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Louise Marston@MarstonLouiseJul 14
Comorbidities and Complications in Parkinson’s Disease in Primary Care - Okunoye - 2026 - European Journal of Neurology - Wiley Online Library @UCL_PCPH @a_schrag @CAPS_UCL onlinelibrary.wiley.com/doi/…

Comorbidities and Complications in Parkinson’s Disease in Primary Care

Many comorbidities are increased in PD. However, they are not associated with greater mortality than in controls, and are not sufficient to explain the increased mortality in PD.

onlinelibrary.wiley.com
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I’m not a BMA member, but this statement is one I support: Reducing funding for clinical academics when numbers are already in decline fails to recognise their contribution to the health & wealth of the UK. The financial saving is minimal but I fear the costs will be substantial
BMA Medical Academics@BMA_AcademicsJul 7
Responding to @officestudents guidance from the Secretary of State for Education setting out funding for 2026-27 for universities that imposes cuts to funding for medical academics: bma.org.uk/bma-media-centre/…

Government must recognise value of medical academics, says BMA as targeted funding cuts announced -...

Press release from the BMA

bma.org.uk
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Our new review in @molpsychiatry: #Depression affects a third of people with #Alzheimer's or #Parkinson's disease, yet current #antidepressants have little benefit. We review disease-specific mechanisms and emerging treatments. nature.com/articles/s41380-0…
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Robert Howard@ProfRobHowardJun 30
Are we on the threshold of re-emergence of highly anatomically restricted neurosurgical procedures to treat the most severe and refractory mental health conditions? Mirroring advances in movement disorders, OCD has already been safely and effectively Rx. doi.org/10.1192/bjp.2026.107…

Cutting through stigma: psychiatry and neurosurgery working together | The British Journal of...

Cutting through stigma: psychiatry and neurosurgery working together

cambridge.org
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Crémieux
@cremieuxrecueilJun 24
RETRACTED! TL;DR: This study, which claimed the time of day had massive effects on immunotherapy efficacy, but which appeared fraudulent, now seems to certainly have been fraudulent. Many thanks to the editors at Nature for handling this quickly and correctly.
Crémieux
@cremieuxrecueilMay 7
A lot of the key details of this study point towards the result not being real. I think we ought to regard it as fraudulent until proven real🧵 To start, the result is as strong as the observational results from the earlier literature. That's very unusual for a trial!
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Kevin Hague@kevverageJun 7
working on something and couldn’t resist sharing some funky graphs … many people seem to think the UK is a high tax economy: this is UK government revenue as share of GDP vs other OECD countries* over time 1/5
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