Blake Highet (@HighetBlake) header
Blake Highet (@HighetBlake) profile picture

Blake Highet

@HighetBlake

Research Fellow, Neurological Foundation NZ Human Brain Bank

Joined October 2019
  • Tweets242
  • Following327
  • Followers182
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Photo by Blake Highet (@HighetBlake)Photo by Blake Highet (@HighetBlake)Photo by Blake Highet (@HighetBlake)Photo by Blake Highet (@HighetBlake)
1/ We are excited to share our new paper in @JExpMed! doi.org/10.1084/jem.20251245 Here we show that α-synuclein, a protein involved in Parkinson’s disease, triggers inflammation at CNS borders and impairs CNS clearance.
Cerebrospinal fluid and dural accumulation of α-synuclein impairs CNS clearance in Parkinson’s...

Cerebrospinal fluid and dural accumulation of α-synuclein impairs CNS clearance in Parkinson’s...

Impaired waste clearance and chronic inflammation are emerging contributors to Parkinson’s disease pathogenesis. Here, Stevenson et al. show that aggregate

rupress.org
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Effects of prolonged post-fixation on vascular biomarkers in postmortem human brains biorxiv.org/content/10.64898… #biorxiv_neursci
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I am hiring! If you enjoyed our recent publication (nature.com/articles/s41588-0…) and are interested in all things systems immunology, paediatric oncology and development, please apply below! Working in the wonderful @CRUK_CI and @Gilbertson_Lab cam.ac.uk/jobs/research-assi…
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Evidence for trans-synaptic propagation of oligomeric tau in human progressive supranuclear palsy, including postmortem PSP brain samples and a living human brain slice culture model nature.com/articles/s41593-0…
Evidence for trans-synaptic propagation of oligomeric tau in human progressive supranuclear palsy

Evidence for trans-synaptic propagation of oligomeric tau in human progressive supranuclear palsy

Nature Neuroscience - McGeachan et al. observe oligomeric tau in synapses from individuals with progressive supranuclear palsy and provide evidence that tau pathology may spread through the brain...

nature.com
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New study identifies the #hypothalamus as a deep brain stimulation target to promote walking recovery after #SpinalCordInjury in preclinical models and in a first-in-human feasibility study. #NeuroRehabilitation #Neuroscience #Neurotrauma @gcourtine nature.com/articles/s41591-0…
Hypothalamic deep brain stimulation augments walking after spinal cord injury

Hypothalamic deep brain stimulation augments walking after spinal cord injury

Nature Medicine - Whole-brain anatomical and activity surveys identify the lateral hypothalamus as a key driver of recovery from spinal cord injury, leading to a deep brain stimulation therapy that...

nature.com
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Happy to interrupt your election feed, to share our own findings. In an effort guided by @sophiejccaron and @JasonSynaptic we have made some interesting findings. Come and check it out.
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Blake Highet retweeted
Eric Topol (@EricTopol) profile picture
Eric Topol
@EricTopol24 Oct 2024
A substantial reduction of #Alzheimers disease associated with semaglutide (Ozempic) in > 1 million people with Type 2 diabetes from a nationwide data resource alz-journals.onlinelibrary.w…
Image from Eric Topol (@EricTopol)
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Jungsu Kim (@jungsukim77) profile picture
Jungsu Kim@jungsukim7725 Jul 2024
I think this should have been published in @NatureMedicine Good catch for @alzdemjournals😍 Title: *****Insufficient***** evidence for an association between iatrogenic Alzheimer's disease and cadaveric pituitary-derived growth hormone alz-journals.onlinelibrary.w… – at Carmel, IN
Insufficient evidence for an association between iatrogenic Alzheimer's disease and cadaveric...

Insufficient evidence for an association between iatrogenic Alzheimer's disease and cadaveric...

A Nature Medicine paper published in January 2024 describes eight cases of iatrogenic Alzheimer's disease in individuals who received cadaveric pituitary-derived human growth hormone. The paper's...

alz-journals.onlinelibrary.wiley.com
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Our paper exploring the antibody labelling signature of neurofibrillary tangle maturity in Alzheimer's disease is out now in @alzdemjournals. doi.org/10.1002/alz.13922
Image from Helen Murray, PhD (@hcmurray6)
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Bess Frost (@bess_frost) profile picture
Bess Frost@bess_frost29 Apr 2024
This was quite fun to co-write! New review on retrotransposons and endogenous retroviruses in neurodegenerative disorders from @joshdubnau and yours truly: go.shr.lc/3wcE0Ls
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Paul Greer (@Greer_Lab) profile picture
Paul Greer@Greer_Lab18 Apr 2024
I'm delighted to share the latest work from our lab in which @HaoChingJiang1 and SungJin Park demonstrate that MS4A1/CD20 functions as a mammalian odorant receptor in a previously uncharacterized population of sensory neurons. rdcu.be/dE8B7
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Since our lab tech Alyson is moving on to grad school (🎉), we are in need of a new tech. We are especially interested in folks who have tissue culture experience as the duties will be to generate primary rodent neurons. Please RT and DM me if interested. utah.peopleadmin.com/posting…
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Exciting PhD project also available! Can *you* help treat X-linked #MND #FTD #ALS?? Domestic and international applicants considered. profiles.auckland.ac.nz/emma…. @FMHS_UoA @UoASciResFellow @FMHS_PGSA @ScienceUoA
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Calling UoA Biomed/ Neurosci students for Hons/ Masters projects in 2024. Help us make discoveries about #MND #ALS brain tissues. Pls retweet. mhsfaculty.auckland.ac.nz/pg… @FMHS_UoA @UoASciResFellow @FMHS_PGSA @ScienceUoA
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Interested in understanding how neurons transport mRNAs in dendrites and control when and where they're used for local protein synthesis? My group is hiring a postdoctoral researcher! elxw.fa.em3.oraclecloud.com/…

Postdoctoral Research Fellow

A postdoctoral position is available in the lab of Dr. Paul Donlin-Asp (https://www.donlin-asp-lab.com/).

elxw.fa.em3.oraclecloud.com
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Blake Highet retweeted
Stephen Turner (@strnr) profile picture
Stephen Turner@strnr21 Mar 2023
openai package: #Rstats pkg interface to OpenAI API github.com/samterfa/openai
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M W (@Michael_E_Ward_) profile picture
M W@Michael_E_Ward_1 Jan 2023
mRNA transport, translation, and decay in adult mammalian central nervous system axons: Neuron cell.com/neuron/fulltext/S08…
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Blake Highet retweeted
Steven Ge (@StevenXGe) profile picture
Steven Ge
@StevenXGe19 Dec 2022
Happy holidays! Introducing RTutor.ai, an AI-powered app that lets you chat with your data in English! RTutor uses Davinci (#ChatGPT’s sibling) to turn requests into R code, which is executed & results are shown instantly, available as a HTML report in seconds. 1/8
Image from Steven Ge (@StevenXGe)
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Alice Ting (@aliceyting) profile picture
Alice Ting
@aliceyting16 Dec 2022
Can we perform unbiased discovery of endogenous proteins that traffick from one organelle to another in living cells? Learn about our new proximity labeling method, TransitID, here: Full video of ASCB lecture at tinyurl.com/3dste3am
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Excited to share our latest paper - Pericytes take up and degrade α-synuclein but succumb to apoptosis under cellular stress. nature.com/articles/s41598-0…
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