@HoebartnerLab

Nucleic Acid Chemistry enthusiasts

 University of Würzburg
chemie.uni-wuerzburg.de/oc/hoebartner-group/home/
Joined October 2020
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  • Following210
  • Followers936
DFG's delegation & VP Karin Jacobs visited New Dehli to honor 50 years of Indo-German Science & Technology Cooperation with @bmbf_Bund & @IndiaDST. More reasons to celebrate: Our partnership with DST for 20 years & the start of the 1st DST-DFG indo-German #IRTG.
A Group photo of (left to right) Dr. Jörg Schneider, DFG; Prof. Karin Jacobs, DFG; Prof. Frank Würthner, University of Würzburg; Prof. Mahesh Hariharan, IISER Thiruvananthapuram; Dr. Praveen Somasundaram, DST; Dr. Rajiv Kumar, DST

ALT A Group photo of (left to right) Dr. Jörg Schneider, DFG; Prof. Karin Jacobs, DFG; Prof. Frank Würthner, University of Würzburg; Prof. Mahesh Hariharan, IISER Thiruvananthapuram; Dr. Praveen Somasundaram, DST; Dr. Rajiv Kumar, DST

Vice President DFG Prof. Karin Jacobs standing in front of a lectern highlighting achievements from 20 years of DFG DST collaboration.

ALT Vice President DFG Prof. Karin Jacobs standing in front of a lectern highlighting achievements from 20 years of DFG DST collaboration.

Dr. Rajiv Kumar, DST; Dr. Alok Krishna Sinha, National Institute of Plant Genome Research; Prof. Sandeep Verma, IIT Kanpur; Dr. Sanjay Mishra, DBT; Dr. Jörg Schneider, DFG; Prof. K.N. Ganeshaiah, UAS Bangalore; Prof. Karin Jacobs, DFG; Dr. Franziska Lange

ALT Dr. Rajiv Kumar, DST; Dr. Alok Krishna Sinha, National Institute of Plant Genome Research; Prof. Sandeep Verma, IIT Kanpur; Dr. Sanjay Mishra, DBT; Dr. Jörg Schneider, DFG; Prof. K.N. Ganeshaiah, UAS Bangalore; Prof. Karin Jacobs, DFG; Dr. Franziska Lange

Group photo of (left to right): Dr. Praveenkumar Somasundaram, DST; Prof. Ashutosh Sharma, INSA; Prof. Abhay Karandikar, DST; Dr. Jitendra Sing, Government of India; Ms. Bettina Stark-Watzinger, Federal Republic of Germany; Prof. Joybrato Mukherjee, DAAD

ALT Group photo of (left to right): Dr. Praveenkumar Somasundaram, DST; Prof. Ashutosh Sharma, INSA; Prof. Abhay Karandikar, DST; Dr. Jitendra Sing, Government of India; Ms. Bettina Stark-Watzinger, Federal Republic of Germany; Prof. Joybrato Mukherjee, DAAD

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Claudia Höbartner retweeted
Würthner Group@wuerthnergroup12 Sep 2024
📣Become part of the International Research Training Group 2991. 🇮🇳🌟🇩🇪 Join one of 12 PIs @Uni_WUE for a PhD in the field of "Photoluminescence in Supramolecular Matrices". ℹ️uni-wuerzburg.de/irtg2991
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The power of chemical synthesis for studying #RNAmodifications by atomic mutagenesis. Check our nitrogen-deficient m6A analogues, and what they tell us about m6A recognition by proteins. just published in @J_A_C_S
J. Am. Chem. Soc.@J_A_C_S7 Mar 2024
Atomic Mutagenesis of N6-Methyladenosine Reveals Distinct Recognition Modes by Human m6A Reader and Eraser Proteins | Journal of the American Chemical Society @HoebartnerLab @Uni_WUE #Mutagenesis #Methyladenosine #m6A #Reader #Eraser #Proteins pubs.acs.org/doi/10.1021/jac…

Atomic Mutagenesis of N6‑Methyladenosine Reveals Distinct Recognition Modes by Human m6A Reader and...

Abstract. N6-methyladenosine (m6A) is an important modified nucleoside in cellular RNA associated with multiple cellular processes and is implicated in dis

pubs.acs.org
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Claudia Höbartner retweeted
J. Am. Chem. Soc.@J_A_C_S7 Mar 2024
Atomic Mutagenesis of N6-Methyladenosine Reveals Distinct Recognition Modes by Human m6A Reader and Eraser Proteins | Journal of the American Chemical Society @HoebartnerLab @Uni_WUE #Mutagenesis #Methyladenosine #m6A #Reader #Eraser #Proteins pubs.acs.org/doi/10.1021/jac…

Atomic Mutagenesis of N6‑Methyladenosine Reveals Distinct Recognition Modes by Human m6A Reader and...

Abstract. N6-methyladenosine (m6A) is an important modified nucleoside in cellular RNA associated with multiple cellular processes and is implicated in dis

pubs.acs.org
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Claudia Höbartner retweeted
Helten Group@HeltenGroupJMU30 Jan 2024
A good start into the new year, check out our new paper in @JOC_OL on BN-Phenanthrene- and BN-Pyrene-Based Fluorescent Uridine Analogues in cooperation with the @HoebartnerLab Group! Congratulations to @Michi_Chemie for your first publication! doi.org/10.1021/acs.orglett.…
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Claudia Höbartner retweeted
Patrick Cramer@mpgpresident17 Jan 2024
Gegen den Rechtsdrift: Wir brauchen eine offene Gesellschaft! Mein Beitrag heute @faznet faz.net/1.9452332?premium=0x…

Wissenschaft und Zuwanderung: „Rechtsdrift schadet unserem Land“

Die aktuelle Rechtsdrift in der Migrationsdebatte schadet unserem Land. Nicht nur die Wissenschaft profitiert von der Zuwanderung. Ein Gastbeitrag

faz.net
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Thrilled to receive the Hansen Family Award and deeply grateful for the honor. Thank you to @BayerFoundation and to everyone who made this possible!
Bayer Foundation@BayerFoundation13 Nov 2023
Here are the winners of this year’s #Science Awards: Congrats to @HoebartnerLab for being awarded with the Hansen Family Award and @gaofir, Dr. Erin Stache, @skinniderlab and Dr. Vivi Maketa for winning the Early Excellence in Science Award. bayer-foundation.com/and-bay…
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Read a News &Views about #SAMURI by @RentmeisterLab in @NatureChemistry nature.com/articles/s41557-0… Thank you for highlighting !
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Pleased to share our latest work, which was just published in @ChemicalScience. Benzylation of biomolecules in a MAT/MTase cascade. Applied to mRNA, you affect translation and immunogenicity. Congratulations to all authors 🎉 @EnzymeNicoCorn, @RMineikaite pubs.rsc.org/en/content/arti…

Post-synthetic benzylation of the mRNA 5′ cap via enzymatic cascade reactions†

mRNAs are emerging modalities for vaccination and protein replacement therapy. Increasing the amount of protein produced by stabilizing the transcript or e

pubs.rsc.org
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Congratulations to all poster prize winners!! And many Thanks to all participants, speakers, chairs, poster presenters, and helping hands!
Andrea Rentmeister@RentmeisterLab15 Sep 2023
Congratulations to all poster prize winners at the DNG meeting, including our @FlorianWeissen1 🥇. Big thanks to @HoebartnerLab for organizing this fantastic conference. 🙏
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#SAMURI is a new #ribozyme for RNA-catalyzed labeling of RNA. It uses a new cell-permeable SAM analogue and generates a novel propargylated nucleotide in RNA. Check out the full story doi.org/10.1038/s41557-023-0… rclcu.be/dlcxN
Universität Würzburg #UniWürzburg@Uni_WUE4 Sep 2023
New #ribozyme #SAMURI uses a new synthetic cofactor to make #RNA in living cells accessible for #ClickChemistry: Congrats on this publication @NatureChemistry to @HoebartnerLab @JoergLab @Helmholtz_HIRI! ➡️ go.uniwue.de/ribozyme-samuri
SAMURI is a new ribozyme that attaches a targeted modification to cellular RNA for click chemistry. (Picture: Working group Claudia Höbartner / University of Würzburg)

ALT SAMURI is a new ribozyme that attaches a targeted modification to cellular RNA for click chemistry. (Picture: Working group Claudia Höbartner / University of Würzburg)

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Still time to apply
Helmholtz Institute Würzburg (HIRI)@Helmholtz_HIRI23 Aug 2023
Are you looking for a #graduate program that will launch your career in the fast-growing field of #RNA-based #medicine? 🧬🎓 @RNAmedBavaria is offering fully-funded #PhD positions (4 years) in Würzburg, Munich, or Regensburg. 👉 Apply by September 17 via rnamed.de!
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Claudia Höbartner retweeted
Angewandte Chemie@angew_chem27 Jun 2023
Ribozyme-Catalyzed Late-Stage Functionalization and Fluorogenic Labeling of RNA (Claudia Hoebartner and co-workers) @Uni_WUE @HoebartnerLab #AngewandteVIP #openaccess thanks to #projektDEAL ow.ly/qXAX50OXTr3

Ribozyme‐Catalyzed Late‐Stage Functionalization and Fluorogenic Labeling of RNA

The methyltransferase ribozyme (MTR1) catalyzes site-specific alkylation of a purine nucleobase to initiate the formation of the 5-amino-4-formylimidazole nucleobase analogue, which serves as the...

onlinelibrary.wiley.com
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Expanding the scope of RNA-catalyzed reactions @Uni_WUE. This work ow.ly/qXAX50OXTr3 #AngewandteVIPs shows how to install a formyl group in RNA using the methyltransferase ribozyme MTR1. exciting applications for site-specific fluorogenic labeling of RNA and more.

Ribozyme‐Catalyzed Late‐Stage Functionalization and Fluorogenic Labeling of RNA

The methyltransferase ribozyme (MTR1) catalyzes site-specific alkylation of a purine nucleobase to initiate the formation of the 5-amino-4-formylimidazole nucleobase analogue, which serves as the...

onlinelibrary.wiley.com
Angewandte Chemie@angew_chem27 Jun 2023
Ribozyme-Catalyzed Late-Stage Functionalization and Fluorogenic Labeling of RNA (Claudia Hoebartner and co-workers) @Uni_WUE @HoebartnerLab #AngewandteVIP #openaccess thanks to #projektDEAL ow.ly/qXAX50OXTr3

Ribozyme‐Catalyzed Late‐Stage Functionalization and Fluorogenic Labeling of RNA

The methyltransferase ribozyme (MTR1) catalyzes site-specific alkylation of a purine nucleobase to initiate the formation of the 5-amino-4-formylimidazole nucleobase analogue, which serves as the...

onlinelibrary.wiley.com
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Claudia Höbartner retweeted
Sharma Lab@SharmaLab110 May 2023
🚨Job Alert for Group Leader Position🚨 @JMU #Würzburg is recruiting a junior group leader in #RNAbiology. Start your own lab in a vibrant, international scientific #RNA and #infection environment and apply by May 31st! ➡️ imib-wuerzburg.de/fileadmin/… @JoergLab @KiskerLab
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Check out how to program alkene-alkyne [2+2] photocycloaddition for DNA interstrand crosslinking to block DNA unwinding by helicases, just published in @J_A_C_S Thanks for the great collaboration with @KiskerLab @RVZ_Wuerzburg @Uni_WUE
J. Am. Chem. Soc.@J_A_C_S19 Apr 2023
Programmable DNA Interstrand Crosslinking by Alkene–Alkyne [2 + 2] Photocycloaddition @Uni_WUE @HoebartnerLab @dfg_public #Programmable #DNA #Crosslinking #Alkene #Alkyne #Photocycloaddition pubs.acs.org/doi/10.1021/jac…

Programmable DNA Interstrand Crosslinking by Alkene–Alkyne [2 + 2] Photocycloaddition

Abstract. Covalent crosslinking of DNA strands provides a useful tool for medical, biochemical, and DNA nanotechnology applications. Here we present a ligh

pubs.acs.org
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📢📢PhD students and postdocs: apply now for the Young Scientist Award Biochemistry 2023 of the GDCh. PIs can recommend their students/postdocs. 👇 en.gdch.de/network-structure… #GDCh_biochem; @StephanHacker2, @Intein, @klanglab, @HoebartnerLab
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Claudia Höbartner retweeted
Ronald Breaker@RonBreaker5 Jan 2023
X-ray model of an NAD+-II #riboswitch by the Micura and Ren labs in @NAR_Open reveals how #ncRNA senses the redox state of a ubiquitous enzyme cofactor. The #aptamer stacks G6 and G42 on the plus-charged nicotinamide ring (cation-pi interaction), and rejects NAD's puckered ring.
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Very grateful & deeply honored to receive the prestigious Gottfried Wilhelm #LeibnizPreis 2023 from #DFG. Big big Thank You to my incredible group, all our collaborators and everyone who made this possible. also thanks for all congrats and wishes today
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Thank you very much! It is a great honor to receive the 2022 Meyerhof Medal @mpi_mr_hd. I am very grateful to my team for their outstanding work!
Max Planck Institute for Medical Research@mpi_mr_hd5 Oct 2022
100 yrs after Otto Meyerhof was awarded the Nobel Prize in Physiology/Medicine. We were honoured to award Dr. Claudia Höbartner last week with the 2022 Meyerhof Medal.🎖️ Congratulations @HoebartnerLab !
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