@HugoAlmarza

Ph.D Cellular and Molecular Biology UC. MSc. in Neurosciences (UValparaiso) Postdoc Research UMayor #CellularBiology #cellsignaling #ER #ER-Phagy

 Santiago, Chile
instagram.com/hugoalmarza
Joined January 2011
  • Tweets22.7K
  • Following3.5K
  • Followers7.4K
Hugo Almarza Salazar retweeted
John Lukens@LukensJohnROct 26
Chronic progressive demyelination induces a microglial state with lysosomal dysfunction @NatureNeuro nature.com/articles/s41593-0…
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Cell Biology J-Club@cell_clubOct 26
<fc>TMEM55B</fc> Maintains Lysosomal Homeostasis and Promotes <fc>ER</fc>–Lysosome Calcium Signaling - Mukae - 2026 - Traffic - Wiley Online Library onlinelibrary.wiley.com/doi/…

TMEM55B Maintains Lysosomal Homeostasis and Promotes ER–Lysosome Calcium Signaling

Hypothetical model: The lysosomal protein TMEM55B interacts with an ER protein complex containing Protrudin and PDZD8 at ER–lysosome membrane contact sites, and also acts to stabilize v-ATPase in...

onlinelibrary.wiley.com
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Hugo Almarza Salazar retweeted
J Cell Science@J_Cell_SciOct 26
In this Cell Science at a Glance article and poster, Eric Chevet, Elodie Lafont & team look at how the ER adapts to stress through various mechanisms, ranging from activation of signalling cascades to physical association with other organelles. journals.biologists.com/jcs/…
JCS poster: Responses to endoplasmic reticulum stress at a glance Eric Chevet, Céline Philippe, Tony Avril, Elodie Lafont

ALT JCS poster: Responses to endoplasmic reticulum stress at a glance Eric Chevet, Céline Philippe, Tony Avril, Elodie Lafont

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Hugo Almarza Salazar retweeted
eLife - the journal@eLifeOct 25
Tau hyperphosphorylation impairs cooperative binding to microtubules and perturbs organelle trafficking in neurons elifesciences.org/articles/1…

Tau hyperphosphorylation impairs cooperative binding to microtubules and perturbs organelle...

Single-molecule motility assays and live-cell imaging in neurons reveal that tau hyperphosphorylation disrupts the formation of cooperative tau envelopes along microtubules and lysosomal transport.

elifesciences.org
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Hugo Almarza Salazar retweeted
Ｊｕｎ　Ｙａｓｕｄａ@jyasuda1Oct 24
ほんまか（今まで誰もしとらんかったんか？）と思う実験。アルツハイマー病などに罹患した患者の脳からタウ線維を抽出、マウス脳に移植することでマウスのタウタンパク質も同様に集合することを示した論文。Nature。 nature.com/articles/s41586-0…

Prion-like transmission of human tau strains in the mouse brain

Nature - Mouse experiments show that Alzheimer’s disease and corticobasal degeneration tau filaments retain their distinct structures during templated seeding, supporting strain-specific tau...

nature.com
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Hugo Almarza Salazar retweeted
Prof. Nikolai Slavov
@slavov_nOct 24
Glycosylation is among the most important modifications in biology. We know relatively little about glycobiology, because it is hard to study. This Nat Rev Methods primer describes our best tools for analyzing glycosylation 🔽
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Mitochondria-ER-lipid droplet crosstalk regulates metabolic adaptation to shear stress via VMP1: Current Biology cell.com/current-biology/ful…

Mitochondria-ER-lipid droplet crosstalk regulates metabolic adaptation to shear stress via VMP1

Rojas et al. show that physiological shear stress triggers rapid mitochondrial remodeling and transient stabilization of ER-mitochondria contact sites in kidney epithelial cells. These contacts...

cell.com
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Hugo Almarza Salazar retweeted
Cell Biology J-Club@cell_clubOct 25
Clathrin-coated tubules mediate rapid and selective protein absorption by lysosome-rich enterocytes biorxiv.org/content/10.64898…

Clathrin-coated tubules mediate rapid and selective protein absorption by lysosome-rich enterocytes

In the digestive tract of neonatal mammals and in fish, lysosome-rich enterocytes (LREs) internalize dietary proteins and digest them intracellularly within a large lysosomal vacuole. Impaired LRE...

biorxiv.org
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Hugo Almarza Salazar retweeted
Cell Biology J-Club@cell_clubOct 25
Structure and function of the DFCP1 membrane barrier responsible for ER microdomain organization in lysosome repair biorxiv.org/content/10.64898…

Structure and function of the DFCP1 membrane barrier responsible for ER microdomain organization in...

The endoplasmic reticulum (ER) forms specialized microdomains that organize autophagy, lipid droplet formation, and the repair of damaged lysosomes. The PI3P-binding protein DFCP1/ZFYVE1 marks these...

biorxiv.org
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Hugo Almarza Salazar retweeted
nature
@NatureOct 24
Nature research paper: GRP75-dependent SIMPA mediates inter-organellar quality control go.nature.com/4zQqXux

GRP75-dependent SIMPA mediates inter-organellar quality control

Nature - Proteotoxic stress drives formation of GRP75-dependent protein aggregates that signal through mitochondria–ER contact sites to activate targeted quality-control pathways, enabling...

nature.com
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Hugo Almarza Salazar retweeted
Cell Biology J-Club@cell_clubOct 23
The AP-1 clathrin adaptor has a conserved role in recycling resident proteins of the trans-Golgi network biorxiv.org/content/10.64898…
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Hugo Almarza Salazar retweeted
Cell Biology J-Club@cell_clubOct 22
RanGAP1 coordinates the ER-lamina interface to drive de novo nuclear envelope reassembly in mouse embryos | Science Advances science.org/doi/10.1126/scia…

RanGAP1 coordinates the ER-lamina interface to drive de novo nuclear envelope reassembly in mouse...

Nuclear envelope (NE) reassembly is essential for the zygote-to-totipotency transition in mammalian embryos. Beyond its classical roles in nuclear transport and maintenance of the RanGTP gradient,...

science.org
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Hugo Almarza Salazar retweeted
Cell Biology J-Club@cell_clubOct 22
BAK and BAX form a multiprotein complex to drive mtDNA efflux and caspase-independent cell death | Science science.org/doi/10.1126/scie…

BAK and BAX form a multiprotein complex to drive mtDNA efflux and caspase-independent cell death

The apoptotic regulators BAX and BAK, once activated, form homo-oligomers to trigger mitochondrial outer membrane permeabilization (MOMP), activating the apoptosome and caspases. Activation of...

science.org
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Hugo Almarza Salazar retweeted
Cell Biology J-Club@cell_clubOct 22
Mitochondrial subpopulations promote cellular responses to changes in metabolic demand and signal transduction | PNAS pnas.org/doi/10.1073/pnas.26…

Mitochondrial subpopulations promote cellular responses to changes in metabolic demand and signal...

When mammalian cells are under increased ATP demand, mitochondria segregate into two distinct subpopulations, one capable of oxidative phosphorylat...

pnas.org
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Hugo Almarza Salazar retweeted
Traffic Journal@TrafficJournalOct 21
Just Published ! #TrafficLights commentary onlinelibrary.wiley.com/doi/…
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Cell Biology J-Club@cell_clubOct 21
The N-Ank protein Ankrd24 shapes neurons and couples to syndapin and the F-actin promoter Cobl-like rupress.org/jcb/article/225/…

The N-Ank protein Ankrd24 shapes neurons and couples to syndapin and the F-actin promoter Cobl-like

Proper neuromorphogenesis is pivotal for neuronal network formation and brain function. Jain, Izadi-Seitz and Ji et al. identify mechanisms and cellular fu

rupress.org
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Hugo Almarza Salazar retweeted
Journal of Cell Biology@JCellBiolOct 20
A team at the University of Basel has identified a molecular switch that controls how cells ensure that the right cargo ends up in the right recycling vesicle. hubs.la/Q04BCR620 See the original article from @Spang_Lab @biozentrum @UniBasel_en hubs.la/Q04BCRdk0

Cellular recycling: A molecular switch directs the cargo

Cells constantly recycle proteins and other cellular components. But how do they ensure that the right cargo ends up in the right recycling vesicle – one of the cell’s transport carriers? A team at...

eurekalert.org
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Hugo Almarza Salazar retweeted
Journal of Cell Biology@JCellBiolOct 20
Spotlight: Clegg, Ferguson et al. (hubs.la/Q04BPJn20) show that PIKfyve inhibition swells #lysosomes, traps Rab #GTPases, and activates #LRRK2 without the GABARAP–CASM pathway. @pfeffersuzanne @StanfordMed discusses the findings: hubs.la/Q04BPHD80

ClC-7 links PIKfyve inhibition to Rab-dependent LRRK2 activity at lysosomes

Clegg et al. show that LRRK2 integrates distinct lysosomal stress signals through stimulus-specific combinations of interactions with Rab GTPases and GABAR

rupress.org
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Hugo Almarza Salazar retweeted
Cell Biology J-Club@cell_clubOct 21
GRP75-dependent SIMPA mediates inter-organellar quality control nature.com/articles/s41586-0…

GRP75-dependent SIMPA mediates inter-organellar quality control

Nature - Proteotoxic stress drives formation of GRP75-dependent protein aggregates that signal through mitochondria–ER contact sites to activate targeted quality-control pathways, enabling...

nature.com
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Hugo Almarza Salazar retweeted
J Cell Science@J_Cell_SciOct 21
In their Review, Kaixiang Ni, Chenchen Shi, Jiantong Jiao, Jun Sun, Yan Chen and Yi Liu describe the multidimensional roles of the unfolded protein response in glioblastoma. journals.biologists.com/jcs/…
Schematics showing the mechanisms of ERS and the UPR. h

ALT Schematics showing the mechanisms of ERS and the UPR. h

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