Irmin Astrator retweeted
Scientists reverse liver cell aging, cutting Alzheimer's linked protein by 50%
Researchers at the University of Southern California have achieved a remarkable result: rejuvenating aging liver cells in elderly rats in just 2 weeks, restoring their ability to remove harmful substances from the bloodstream.
Using an experimental drug called cinaciguat, they
Reduced amyloid beta by approximately 50%, bringing blood levels back to those seen in young rats. Amyloid-beta is strongly associated with Alzheimer's disease.
Restored LDL (bad cholesterol) to youthful levels, suggesting potential benefits for cardiovascular health.
Reversed key signs of cellular aging in the liver's specialized blood vessel lining cells, reopening microscopic pores that deteriorate with age.
Restored an important cellular communication pathway that helps the liver clear harmful substances from circulation.
The exciting implication here is that rejuvenating one organ might help protect others, potentially opening a new route toward preventing multiple age related diseases simultaneously.
Irmin Astrator retweeted
Next step: Longevity and Rejuvenation. We are almost there.
Researchers in Bonn turned blood cells from an 80-year-old into neural stem cells with a molecular age below 20. More than 60 years younger by epigenetic clocks, which estimate age from chemical marks on DNA.
The team directly reprogrammed blood precursor cells into neural stem cells, skipping the usual pluripotent stem cell stage. The rejuvenation unfolded gradually and could be tracked for over 100 days.
Irmin Astrator retweeted
instead of watching Netflix tonight, give 2 hours to this video
Codex GPT-6 Astra FULL COURSE that teaches you how to BUILD and AUTOMATE anything.
I've seen $500 courses that teach less than this video alone.
Watch it and Bookmark it now.
Irmin Astrator retweeted
Cosmos Deep Dive
📋Own A Space Station
🤝Alliances
🛰️Orbital Bases
📡Space Hulks
🚀Anniversary Expedition
🗺️Star Map
💎Deep-Space Looting
🪨Asteroid Belts
🦠Infested Outposts
☀️The Sun
🧙♀️Dev Commentary
🧲Tractor Beam
❄️Ice Fields
🪐Outposts
⛰️Improved Terrain
🔫Shipbreaking
Irmin Astrator retweeted
🚀 AuK is officially here. Nano banana🍌 for audio
An open-source foundation model for unified speech generation and editing.
Natural-language instructions + reference audio. One interface.
Zero-shot TTS. Instruction-controlled generation. Content editing. Whisper-conversion. De-accent. Timbre/style/emotion edit. Speed/Pitch control. Enhancement, denoising, multi-speaker and music separation.
Also releasing AuK-Flash: 4-step inference. ~4.5× faster under matched conditions.
Code, weights, and demo are live. Try it and share your feedback.
🤗 Paper & upvote: huggingface.co/papers/2609.0…
⭐ GitHub & star: github.com/Tencent-Hunyuan/A…
Irmin Astrator retweeted
I turned my Astra game into a skill! It's called Dream Loop: Astra dreams up the AAA version of your game, then loops till it gets there.
Here's a demo I one-shot in 1 hour, 2% weekly quota, no external assets. Prompt and link in replies. Absolutely free. Enjoy!
Irmin Astrator retweeted
Introducing Hy3D WorldClaw——an agentic workflow that generates large scale 3D open worlds from text prompts.🚀🚀🚀
Not video, Not Gaussian Splatting, Every scene generated by WorldClaw is freely explorable and built entirely from editable, game-ready 3D assets with high-quality geometry and textures.
Project Page: tencent-hunyuan.github.io/Hu…
Irmin Astrator retweeted
Always loved these topographic maps and wanted to create something similar with Three.js.
3 hours in Claude Code with Fable.
Irmin Astrator retweeted
I'm vibe coding a beat em up game (e.g., Double Dragon / Streets of Rage)
Always important to have some 'cheat codes' while debugging 😉
Makes playtesting the game's progression much easier
Irmin Astrator retweeted
Claude just became a craacked video game designer.
With the launch of Unreal Engine's MCP server last week, you can now build entire video games just by talking to Claude.
I spent the past few days building with it, and I'm telling you, this is going to forever change how video games get made and who gets to make them.
In this video I show you exactly how to set up the Unreal Engine MCP yourself and run through three demos: building a full playable city, cloning a real city from Google Earth, and creating custom buildings in Blender.
Here's the agent harness I mention too: github.com/per-simmons/unrea…
Intro
What I built in a few hours
Setting up the Unreal MCP server
Fixing the port 8000 connection issue
The agent harness that avoids the pitfalls
Demo 1: Building a city with City Sample
Demo 2: Cloning a real city from Google Earth with Cesium
Demo 3: Custom buildings with Blender headless
Outro
Irmin Astrator retweeted
From Marble to Unreal Engine.
Learn how to bring Marble-generated splats into @UnrealEngine using the VIVE Mars Nova 3DGS Plugin, including collision setup, environment lighting, and scene configuration.
Watch here ↓
Irmin Astrator retweeted
Drive characters’ bodies, faces, and more from regular video with the MetaHuman Animator Markerless Motion Capture plugin on @Fab. No suits or markers needed!: epic.gm/metahuman-markerless…
Irmin Astrator retweeted
New in ChatGPT: a better way to schedule tasks.
Scheduled tasks are faster, more reliable, and easier to manage from the new Scheduled page.
The new scheduled tasks experience is rolling out to Go, Plus, Pro, Business, and Enterprise users on web and mobile.
Irmin Astrator retweeted
Unreal Engine 5.8 ships today with experimental MCP server support:
Your sources, your pipeline and your workflow—simply configure the MCP plugin and connect to any agent. Get familiar with the MCP server and the PCG Primitive Plugin today and see what teams can build together: epic.gm/ue-5-8-blog
Irmin Astrator retweeted
GPT-Realtime 2 is the future of the operating system.
I've been experimenting with it for a couple weeks now, and I gotta say, it's pretty gosh darn incredible.
Opening apps, searching the web, even editing in Premiere. All with just my voice.
And it only takes a few prompts to set up.
In this video I'll show you exactly how.
0:00 Intro
1:46 What is GPT-Realtime 2?
4:46 Setting it up (no coding)
7:53 Fixing the always-on mic (push-to-talk)
9:41 Demo: searching the web
11:38 Demo: connecting apps via MCP (Obsidian)
14:13 Demo: controlling Premiere Pro (accessibility tree)
18:00 Honest caveats
19:00 Outro
Irmin Astrator retweeted
One of my favorite things about gaussian splats is how quickly a few images can become something you can explore.
This environment was stitched together from three images using @theworldlabs
Breakdown below ↓