Steve Mount on intermittent fasting, metabolic health, aging and longevity. Intermittent fasting is sustainable; I've been at it for over 20 years.
College Park, MD
Joined January 2011
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I've created a Google doc with links to information about intermittent fasting.
ongen.us/IFdietLinks
Let me know what's missing.
Intermittent Fasting retweeted
Good assessment of 4 wearables in this N of 1 study by @nicnguyen of @ouraring,@WHOO, Fitbit Air, and Apple Watch
gift link wsj.com/tech/personal-tech/o…
Alternate day fasting (which I've done for 21 yrs) seems best.
"more substantial weight losses ... accompanied by reductions in visceral fat and cardiometabolic improvements." "lowered total cholesterol, triglycerides, and non-high density lipoprotein"
bmj.com/content/389/bmj-2024…
Intermittent fasting has emerged as a popular dietary intervention, however, questions remain about its long term efficacy, feasibility, and effects on cardiometabolic variables.
What can we learn from a new study? This Editorial unpicks the findings
bmj.com/content/389/bmj.r115…
Intermittent Fasting retweeted
Top researcher quits NIH, citing censorship under RFK Jr.
Watch the full video here: tinyurl.com/4fhc6k2c
If you are a scientist, or a nutritionist who follows the science, and you think beef tallow is healthier than seed oils, or if you just avoid seed oils, tell me why.
I'm looking for citations.
Now published at ijbs.com/v21p1852
"These findings [in mice] suggest that parental IF can impart enduring metabolic benefits to offspring and may serve as an effective strategy to mitigate the risks of obesity and diabetes in future generations."
Do Intermittent Fasting parents pass benefits to their offspring? We have some answers. Now, students are uncovering the mechanisms. Excited to share our work, now accepted in IJBS! @MAPP_latrobe @SABE_latrobe @LIMSLTU @latrobe @IFdiet 🎉
ijbs.com/ms/acceptms
I literally laughed out loud when I read @SenBillCassidy quoted as saying that Kennedy would restore trust in the CDC, FDA and NIH.
The opposite is true. Kennedy will almost certainly compromise all three, and a lack of trust will follow.
Wake up and drink your coffee! "Lower risks of all-cause mortality and cardiovascular mortality were observed in people who mostly drank coffee in the morning." If you keep drinking coffee all day, not so much.
The link to MedPage is
medpagetoday.com/primarycare…
The link to the research itself is
doi.org/10.1093/eurheartj/eh…
The title is "Coffee drinking timing and mortality in US adults" and it was published in The European Heart Journal.
The short-chain fatty acids (SCFAs) have beneficial health effects, are produced by microbial metabolism and are unique acyl lysine histone marks. These papers show that the last bit is important; it's a mechanism by which the microbiome alters gene expression.
How eating fiber->short-chain fatty acid (SCFA) metabolites->anti-cancer effects
nature.com/articles/s42255-0…
nature.com/articles/s42255-0…
@NatMetabolism
Interest in intermittent fasting appears to be lessening. There is an annual peak in Google searches right around this time of year, with the highest being 2020. Maybe this reflects the fact that most people already know what they want to know.
This is an important read.
Blue zones are places where deaths are not recorded.
In one case "at least 72% of centenarians were dead, missing or essentially pension-fraud cases."
"The secret to living to 110 was, don’t register your death."
‘The data on extreme human ageing is rotten from the inside out’ – Ig Nobel winner Saul Justin Newman
theconversation.com/the-data…
Each day, including my fast days (3 per week, each about 23 hours) I do have a very small "breakfast."
It's 1 tbs. yogurt, 2 tbs. half and half (in my coffee) and 5 mls. cod liver oil.
This totals 100 calories, 10 g. fat, 3 g. protein and 1 g. carbs.
I do it to spare protein.
The simple way to improve blood sugar stability is (no surprise) intermittent fasting.
Scientists Discover Simple Way To Improve Blood Sugar Stability Without Cutting Calories | scitechdaily.com/scientists-…
A more balanced (and non-paywalled) view of the recent paper on Intermittent fasting and intestinal stemness.
"Fasting helps intestinal stem cells regenerate and heal injuries but also leads to a higher risk of cancer in mice, MIT researchers report."
news.mit.edu/2024/study-reve…
Intermittent Fasting retweeted
Epigenetic aging clocks have become a commonly used metric in medical research and are being marketed to consumers. The new Ground Truths with @prof_horvath, who discovered these clocks a decade ago, provides a frank appraisal of their progress, limitations, and promise. With transcript and links to relevant citations.
[Link in my profile]
Wow!
Our new arXiv paper: We built a generative AI model of blood glucose levels from 10 million continuous glucose monitoring measurements of 11,000 people from the Human Phenotype Project
We show that our model can predict clinical parameters such as liver-related parameters, blood lipids, and sleep-related indices. The model can also predict onset of future health outcomes even 4 years in advance, as well as outcomes of randomized clinical trials
We also integrated dietary data into the models and show that the enhanced model can accurately generate blood glucose levels using only dietary intake data, simulate outcomes of dietary interventions, and predict individual responses to specific foods.
The model also performs well on 15 different external datasets from 5 different geographical regions and 6 different continuous glucose monitoring devices
Paper: arxiv.org/abs/2408.11876
Data: humanphenotypeproject.org/
Great work led by @GLutsker, Gal Sapir, @nastya_godneva, @smadarshilo, @H_Rossman in collaboration with @SamochaBonetD and @nvidia researchers @GalChechik @MannorShie @eli_meirom
There have been literally thousands of these posts. I don't understand why Google can't write a desktop app or bring back the browser interface for Fitbit.
Intermittent Fasting retweeted
New @Nature
"Post-fast refeeding leads to a burst in [intestinal] stem-cell-driven regeneration and tumorigenicity"
nature.com/articles/s41586-0…
@justsaysinmice
A consensus on what "intermittent fasting" means.
cell.com/cell-metabolism/ful…
