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Imran

@ImranHouse

Biologist. Views are my own.

Joined August 2009
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Excited to share that my PhD work is out in @Nature today! We engineered armoured CAR T cells to express therapeutic payloads only at the tumour site, to improve their safety and efficacy for the treatment of solid cancers. 1/14 nature.com/articles/s41586-0…
Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery

Rewiring endogenous genes in CAR T cells for tumour-restricted payload delivery

Nature - A CRISPR knock-in strategy that uses endogenous gene regulatory mechanisms can engineer ‘armoured’ CAR T cells that secrete proinflammatory cytokines directly within a tumour...

nature.com
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Introducing oNKo-044 🔦 onko-innate.com/pipeline/pip… #cytokinetherapy #immunotherapy #immunooncology #australianbiotech #cancerresearch 🧵 1/6
Image from Audax Bio (@audax_bio)
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Protein engineering and biotherapeutics: building tools & therapies for the #immunooncology revolution 💡 At oNKo-innate, we've developed an advanced #proteinengineering and #biotherapeutics platform: onko-innate.com/platforms
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Spotlight on our oNKo-001 therapy for solid tumors! oNKo-001 is a reduced-potency IL-12 fusion protein that overcomes several major issues that have hampered the clinical translation of IL-12. Read more on our pipeline page: onko-innate.com/pipeline/pip… #cytokines #cancertreatment
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This week we’re celebrating our newly appointed Chief Technology Officer, @DrIvaNikolic 👏 As CTO, Iva will drive the development and implementation of new technologies, enabling discoveries that will form the basis for a new wave of #cancertherapies. Congrats, Iva!
Image from Audax Bio (@audax_bio)
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OUR NEW AD IS LIVE!   You’re the Voice that will make history.   On 14 October, we know we all can stand together with the power to be powerful.   #HistoryIsCalling, so #VoteYes. Are you in? John Farnham is.   #UluruStatement #StayTrue2Uluru #YoureTheVoice #VoteYes
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Chloe Kelly, always delivering when it matters! Nerves of steel! 🏴󠁧󠁢󠁥󠁮󠁧󠁿 #ENGNGA
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Our latest work is out @ImmunityCP ! Find out how we used surface proteome analyses to explore circulating and tissue-resident memory T cells diversity across tissues & many more!👇 authors.elsevier.com/c/1hL2j… @LMackayLab @TheDohertyInst #teamTRM 🧪🔬🧵
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2/ Main findings: - Last author of paper is 20% more likely to be credited as IP inventor than 1st author. - This is more skewed in #biology and less in #engineering. - Female 1st authors are much more likely to be *excluded* from patents than male 1st authors.
Image from James Zou (@james_y_zou)
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It was a privilege to present @apvicongress 🧬🦠👩‍🔬 Thank you to the organisers for the opportunity and the attendees for your insightful questions and feedback! #apvic2023
Image from Emily Derrick (@emsderrick)
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👩🏻‍🔬 PhD completion seminar done! Thank you to my wonderful supervisors @paulbeavis4 @ImranHouse and Phil for your guidance and support over the years. Couldn't have asked for a better PhD project and experience (despite all the cricket chat 😆). Now to finish writing my thesis...
Image from Amanda Chen (@_amandachen)
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Happy to share the early release of our work on CD5+ dendritic cells and their important role in anti-tumor immunity and response to Immunotherapy, now out at @ScienceMagazine. An incredible team work by Mingyu He, coauthor Kate Roussak and many others!! science.org/doi/10.1126/scie…
CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses

CD5 expression by dendritic cells directs T cell immunity and sustains immunotherapy responses

CD5 on dendritic cells is immunostimulatory and potentiates tumor-specific T cell responses during immunotherapy.

science.org
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Looking for a research assistant to join the team and help push a promising new CAR T approach towards clinical translation. See details below and reach out if interested @PeterMacRes seek.com.au/job/60621739?typ…
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Travis head right now… 🙃 #AUSvIND
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For all those industry and biotech startup curious - @ImranHouse, @Dr_Nick_Bikes and Stephane Chappaz will be repping the oNKo team @LorneCancer this week - track them down for a chat! 🙏
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A hairy subgroup of the @oNKo_innate R&D team are putting a Mo where their mouth is to raise mo money for men's health. Please take a mo to donate what you can 🙏 movember.com/t/team-onko?mc=… – at Melbourne, Victoria
Image from Nicholas Huntington (@Dr_Nick_Bikes)
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WORLD CRISPR DAY is back! We'd love for you to join us at @Synthego's amazing, virtual, free scientific symposium that brings together genome engineering scientists, clinicians, and thought leaders from around the world! Please register for free at worldcrisprday.com
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Currently looking for a research assistant to join our team. Great opportunity to work directly under the supervision of one of the best @JunyunLai. Position closes this Thursday, please reach out if interested or need more time to apply. petermac.mercury.com.au/View…
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When the editorial makes the front page...
Image from Michael Rowland (@mjrowland68)
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Speaking with the Murugappan family about my decision today as interim Home Affairs Minister to enable them to return #HometoBilo, the big-hearted QLD town which has embraced them so warmly #auspol
Image from Jim Chalmers MP (@JEChalmers)
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